Stimulation of prostanoid IP and EP2 receptors dilates retinal arterioles and increases retinal and choroidal blood flow in rats

European Journal of Pharmacology

Volumn 570, Issue 1-3, 2007, Pages 135-141

  Mori, Asami ^a   Saito, Maki ^a   Sakamoto, Kenji ^a   Narita, Masami ^b   Nakahara, Tsutomu ^a   Ishii, Kunio ^a  

^a KITASATO UNIVERSITY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Fundus blood flow; Prostanoid EP receptor agonist; Prostanoid IP receptor; Retinal blood vessel; Vasodilatory prostaglandin

Indexed keywords

ADENYLATE CYCLASE; ADRENALIN; FORSKOLIN; NORADRENALIN; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; PROSTANOID RECEPTOR; TETRODOTOXIN;

ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; CHOROID; EYE FUNDUS; HEMODYNAMICS; LASER DOPPLER FLOWMETRY; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RETINA BLOOD FLOW; RETINA BLOOD VESSEL; SYSTEMIC CIRCULATION; VASODILATATION;

ANIMALS; DINOPROSTONE; EPOPROSTENOL; FORSKOLIN; MALE; METHYL ETHERS; RATS; RATS, WISTAR; RECEPTORS, PROSTAGLANDIN; RECEPTORS, PROSTAGLANDIN E; REGIONAL BLOOD FLOW; RETINA; RETINAL ARTERY; RETINAL VEIN; VASODILATOR AGENTS;

EID: 34547904713     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.05.052     Document Type: Article

References (39)

1. Abran D., Varma D.R., Li D.Y., and Chemtob S. Reduced responses of retinal vessels of the newborn pig to prostaglandins but not to thromboxane. Can. J. Physiol. Pharm. 72 (1994) 168-173
2. 2 receptor and receptor-coupled functions in the choroidal vasculature of the pig during development. Circ. Res. 80 (1997) 463-472
3. Abran D., Varma D.R., and Chemtob S. Regulation of prostanoid vasomotor effects and receptors in choroidal vessels of newborn pigs. Am. J. Physiol., Regul. Integr. Comp. Physiol. 272 (1997) R995-R1001
4. 2. Am. J. Physiol. 277 (1999) H924-H930
5. 2 receptors in control of murine renal hemodynamics. Am. J. Physiol. Heart: Circ. Physiol. 280 (2001) H327-H333
6. 2 and papaverine. Acta Physiol. Scand. 114 (1982) 217-224
7. Breyer R.M., Bagdassarian C.K., Myers S.A., and Breyer M.D. Prostanoid receptors: subtypes and signaling. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 661-690
8. Chemtob S., Laudignon N., Beharry K., Rex J., Varma D., Wolfe L., and Aranda J.V. Effects of prostaglandins and indomethacin on cerebral blood flow and cerebral oxygen consumption of conscious newborn piglets. Dev. Pharmacol. Ther. 14 (1990) 1-14
9. Chemtob S., Beharry K., Rex J., Chatterjee T., Varma D.R., and Aranda J.V. Ibuprofen enhances retinal and choroidal blood flow autoregulation in newborn piglets. Invest. Ophthalmol. Visual Sci. 32 (1991) 1799-1807
10. G-nitro-L-arginine-treated rats. J. Cardiovasc. Pharmacol. 35 (2000) 630-637
11. Coleman R.A., Smith W.L., and Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46 (1994) 205-229
12. De La Cruz J.P., Gonzalez-Correa J.A., Guerrero A., and de la Cuesta F.S. Pharmacological approach to diabetic retinopathy. Diabetes/Metab. Res. Rev. 20 (2004) 91-113
13. Delaey C., and Van de Voorde J. Retinal arterial tone is controlled by a retinal-derived relaxing factor. Circ. Res. 83 (1998) 714-720
14. Delaey C., and Van De Voorde J. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res. 32 (2000) 249-256
15. Feng L.J., Berger B.E., Lysz T.W., and Shaw W.W. Vasoactive prostaglandins in the impending no-reflow state: evidence for a primary disturbance in microvascular tone. Plast. Reconstr. Surg. 81 (1988) 755-767
16. Flammer J., Orgul S., Costa V.P., Orzalesi N., Krieglstein G.K., Serra L.M., Renard J.P., and Stefansson E. The impact of ocular blood flow in glaucoma. Prog. Retin. Eye Res. 21 (2002) 359-393
17. Flower R.W., McLeod D.S., Wajer S.D., Sendi G.S., Egner P.G., and Dubin N.H. Prostaglandins as mediators of vasotonia in the immature retina. Pediatrics 73 (1984) 440-444
18. Grieshaber M.C., and Flammer J. Blood flow in glaucoma. Curr. Opin. Ophthalmol. 16 (2005) 79-83
19. Hardy P., Abran D., Li D.Y., Fernandez H., Varma D.R., and Chemtob S. Free radicals in retinal and choroidal blood flow autoregulation in the piglet: interaction with prostaglandins. Invest. Ophthalmol. Visual Sci. 35 (1994) 580-591
20. Hardy P., Beauchamp M., Sennlaub F., Gobeil Jr. F., Tremblay L., Mwaikamb B., Lachapelle P., and Chemtob S. New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. Prostaglandins Leukot. Essent. Fat. Acids 72 (2005) 301-325
21. Hata Y., Clermont A., Yamauchi T., Pierce E.A., Suzuma I., Kagokawa H., Yoshikawa H., Robinson G.S., Ishibashi T., Hashimoto T., Umeda F., Bursell S.E., and Aiello L.P. Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor. J. Clin. Invest. 106 (2000) 541-550
22. 2-induced constriction of porcine large cerebral arteries. J. Cereb. Blood Flow Metab. 24 (2004) 305-316
23. Kaley G., Hintze T.H., Pazenbeck M., and Messina F.J. Role of prostaglandins in microcirculatory function. Adv. Prostaglandin Thromboxane Leukotriene Res. 13 (1985) 27-35
24. Kaneko Y., Saito M., Mori A., Sakamoto K., Nakahara T., and Ishii K. Vasodilator effects of adrenomedullin on retinal arterioles in streptozotocin-induced diabetic rats. J. Ocular Pharmacol. Ther. 22 (2006) 317-322
25. Kosaka T. The effects of prostaglandins on the blood-retinal barrier. Nippon. Ganka. Zasshi. 99 (1995) 412-419
26. Mori A., Saito M., Sakamoto K., Nakahara T., and Ishii K. Intravenously administered vasodilatory prostaglandins increase retinal and choroidal blood flow in rats. J. Pharmacol. Sci. 103 (2007) 103-112
27. Nakazawa T., Kaneko Y., Mori A., Saito M., Sakamoto K., Nakahara T., and Ishii K. Attenuation of nitric oxide- and prostaglandin-independent vasodilation of retinal arterioles induced by acetylcholine in streptozotocin-treated rats. Vasc. Pharmacol. 46 (2007) 153-159
28. Narumiya S., Sugimoto Y., and Ushikubi F. Prostanoid receptors: structures, properties, and function. Physiol. Rev. 79 (1999) 1193-1226
29. Nielsen P.J., and Nyborg N.C. Contractile and relaxing effects of arachidonic acid derivatives on isolated bovine retinal resistance arteries. Exp. Eye Res. 50 (1990) 305-311
30. Parkington H.C., Coleman H.A., and Tare M. Prostacyclin and endothelium-dependent hyperpolarization. Pharmacol. Res. 49 (2004) 509-514
31. Riva C.E., Sinclair S.H., and Grunwald J.E. Autoregulation of retinal circulation in response to decrease of perfusion pressure. Invest. Ophthalmol. Visual Sci. 21 (1981) 34-38
32. Robinson F., Riva C.E., Grunwald J.E., Petrig B.L., and Sinclair S.H. Retinal blood flow autoregulation in response to an acute increase in blood pressure. Invest. Ophthalmol. Visual Sci. 27 (1986) 722-726
33. Schmetterer L., and Wolzt M. Ocular blood flow and associated functional deviations in diabetic retinopathy. Diabetologia 42 (1999) 387-405
34. Starr M.S. Effects of prostaglandin on blood flow in the rabbit eye. Exp. Eye Res. 11 (1971) 161-169
35. Sugimoto Y., and Narumiya S. Prostaglandin E receptors. J. Biol. Chem. 282 (2007) 11613-11617
36. 4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 141 (2000) 1554-1559
37. 1- and TP-receptors involved in the contraction of human pulmonary veins. Br. J. Pharmacol. 134 (2001) 1671-1678
38. Wizemann A., Ebinger G., Krey H., and Wizemann V. Biphasic action of prostacyclin on intraocular pressure. Ophthalmologica 184 (1982) 204-209
39. 2 receptors. Hypertension 35 (2000) 1129-1134