Effects of pentoxifylline and alprostadil on ocular hemodynamics in healthy humans

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 2, 2007, Pages 815-819

  Dorner, Guido T ^a   Zawinka, Claudia ^a   Resch, Hemma ^a   Wolzt, Michael ^a   Schmetterer, Leopold ^a   Garhofer, Gerhard ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

PENTOXIFYLLINE; PLACEBO; PROSTAVASIN; PROSTAGLANDIN E1; VASODILATOR AGENT;

ADULT; ANALYZER; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL DIAMETER; CHOROID; CIRCULATION; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ERYTHROCYTE; EYE; EYE BLOOD FLOW; EYE FUNDUS; FLOW RATE; HEMODYNAMICS; HUMAN; INTERFEROMETRY; INTRAOCULAR PRESSURE; LASER DOPPLER FLOWMETRY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PULSE RATE; RETINA BLOOD FLOW; RETINA BLOOD VESSEL; RETINA VEIN; BLOOD FLOW; BLOOD FLOW VELOCITY; CONTROLLED CLINICAL TRIAL; MIDDLE AGED; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; VASCULARIZATION;

ADULT; ALPROSTADIL; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CHOROID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ERYTHROCYTES; HUMANS; INTRAOCULAR PRESSURE; LASER-DOPPLER FLOWMETRY; MALE; MIDDLE AGED; PENTOXIFYLLINE; REGIONAL BLOOD FLOW; RETINAL VESSELS; VASODILATOR AGENTS;

EID: 33847712938     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-0823     Document Type: Article

References (30)

1. Haefliger IO, Flammer J, Beny JL, Luscher TF. Endothelium-dependent vasoactive modulation in the ophthalmic circulation. Prog Retin Eye Res. 2001;20:209-225.
2. Schmetterer L, Polak K. Role of nitric oxide in the control of ocular blood flow. Prog Retin Eye Res. 2001;20:823-847.
3. Acciavatti A, Laghi Pasini F, Capecchi PL, et al. Effects of alprostadil on blood rheology and nucleoside metabolism in patients affected with lower limb chronic ischaemia. Clin Hemorheol Microcirc. 2001;24:49-57.
4. Saladino CF, Kosacolsky-Singer C, Fox R, Nethala V, Feffer SE, Jonas EA. The effect of parenteral lipid emulsion-induced hyperlipidemia on prostaglandin E1 modulation of platelet function. Artery. 1993;20:303-313.
5. Ohno Y, Kawai M, Arii Y, Mizutani S. Effect of prostaglandin E1 on ophthalmic artery velocimetry in a pre-eclamptic woman with visual disturbance caused by retinal arterial narrowing. Gynecol Obstet Invest. 2002;53:68-70.
6. Steigerwalt RD Jr, Pescosolido N, Corsi M, Cesarone MR, Belcaro GV. Acute branch retinal arterial embolism successfully treated with intravenous prostaglandin E1: case reports. Angiology. 2003; 54:491-493.
7. Schmetterer L, Kemmler D, Breiteneder H, et al. A randomized, placebo-controlled, double-blind crossover study of the effect of pentoxifylline on ocular fundus pulsations. Am J Ophthalmol. 1996;121:169-176.
8. Kruger A, Matulla B, Wolzt M, et al. Short-term oral pentoxifylline use increases choroidal blood flow in patients with age-related macular degeneration. Arch Ophthalmol. 1998;116:27-30.
9. Sonkin PL, Kelly LW, Sinclair SH, Hatchell DL. Pentoxifylline increases retinal capillary blood flow velocity in patients with diabetes. Arch Ophthalmol. 1993;111:1647-1652.
10. Sonkin PL, Sinclair SH, Hatchell DL. The effect of pentoxifylline on retinal capillary blood flow velocity and whole blood viscosity. Am J Ophthalmol. 1993;115:775-780.
11. Wolzt M, Schmetterer L, Rheinberger A, et al. Comparison of non-invasive methods for the assessment of haemodynamic drug effects in healthy male and female volunteers: sex differences in cardiovascular responsiveness. Br J Clin Pharmacol. 1995;39: 347-359.
12. Schmetterer L, Lexer F, Unfried C, Sattmann H, Fercher AF. Topical measurement of fundus pulsations. Opt Eng. 1995;34:711-716.
13. Schmetterer L, Dallinger S, Findl O, et al. Noninvasive investigations of the normal ocular circulation in humans. Invest Ophthalmol Vis Sci. 1998;39:1210-1220.
14. Schmetterer L, Dallinger S, Findl O, Eichler H, Wolzt M. A comparison between laser interferomteric measurement of fundus pulsation and pneumotonometric measurement of pulsatile ocular blood flow. I. Baseline considerations. Eye. 2000;14:39-45.
15. Riva CE, Cranstoun SD, Grunwald JE, Petrig BL. Choroidal blood flow in the foveal region of the human ocular fundus. Invest Ophthalmol Vis Sci. 1994;35:4273-4281.
16. Riva CE, Grunwald JE, Sinclair SH, Petrig BL. Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci. 1985;26:1124-1132.
17. Riva CE, Grunwald JE, Sinclair SH, O'Keefe K. Fundus camera based retinal LDV. Appl Opt. 1981;20:117-120.
18. Polak K, Dorner GT, Kiss B, et al. Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol. 2000;84:1285-1290.
19. Komaba Y, Kitamura S, Terashi A. Effect of prostaglandin E1 on cerebral blood flow in patients with chronic cerebral infarction. Intern Med. 1998;37:841-846.
20. Pournaras C, Tsacopoulos M, Chapuis P. Studies on the role of prostaglandins in the regulation of retinal blood flow. Exp Eye Res. 1978;26:687-697.
21. Kitanishi K, Harino S, Suzuki M, Okamoto N, Reinach P. Liposomal prostaglandin E1 enhances optic nerve head blood flow in cats. J Ocul Pharmacol Ther. 2001;17:115-122.
22. Kohner EM, Patel V, Rassam SM. Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes. 1995;44:603-607.
23. Haider DG, Bucek RA, Giurgea AG, et al. PGE1 analog alprostadil induces VEGF and eNOS expression in endothelial cells. Am J Physiol. 2005;289:H2066-H2072.
24. Marchesi S, Pasqualini L, Lombardini R, et al. Prostaglandin E1 improves endothelial function in critical limb ischemia. J Cardiovasc Pharmacol. 2003;41:249-253.
25. Krakau CE. A model for pulsatile and steady ocular blood flow. Graefes Arch Clin Exp Ophthalmol. 1995;233:112-118.
26. Langham ME, Farrell RA, O'Brien V, Silver DM, Schilder P. Blood flow in the human eye. Acta Ophthalmol Suppl. 1989;191:9-13.
27. Polska E, Polak K, Luksch A, et al. Twelve hour reproducibility of choroidal blood flow parameters in healthy subjects. Br J Ophthalmol. 2004;88:533-537.
28. Magnusson M, Bergstrand IC, Bjorkman S, Heijl A, Roth B, Hoglund P. A placebo-controlled study of retinal blood flow changes by pentoxifylline and metabolites in humans. Br J Clin Pharmacol. 2006;61:138-147.
29. 2. Br J Ophthalmol. 1997;81: 360-364.
30. Yu DY, Townsend R, Cringle SJ, Chauhan BC, Morgan WH. Improved interpretation of flow maps obtained by scanning laser Doppler flowmetry using a rat model of retinal artery occlusion. Invest Ophthalmol Vis Sci. 2005;46:166-174.