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Volumn 118, Issue 9, 2010, Pages 571-576

Mechanisms of diabetic nephropathy - Old buddies and newcomers part 1

Author keywords

diabetes; disease mechanism; nephropathy

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ANGIOTENSIN ANTAGONIST; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RUBOXISTAURIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 77958114639     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0030-1255051     Document Type: Review
Times cited : (9)

References (56)
  • 1
    • 0345505677 scopus 로고    scopus 로고
    • Low glomerular filtration rate in normoalbuminuric type 1 diabetic patients: An indicator of more advanced glomerular lesions
    • Caramori ML, Fioretto P, Mauer M. Low glomerular filtration rate in normoalbuminuric type 1 diabetic patients: an indicator of more advanced glomerular lesions. Diabetes 2003 52 1036-1040
    • (2003) Diabetes , vol.52 , pp. 1036-1040
    • Caramori, M.L.1    Fioretto, P.2    Mauer, M.3
  • 3
    • 67649635807 scopus 로고    scopus 로고
    • Renal and retinal effects of enalapril and losartan in type 1 diabetes
    • et al
    • Mauer M, Zinman B, Gardiner R, et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes. N Engl J Med 2009 361 40-51
    • (2009) N Engl J Med , vol.361 , pp. 40-51
    • Mauer, M.1    Zinman, B.2    Gardiner, R.3
  • 4
    • 0038323914 scopus 로고    scopus 로고
    • Regression of microalbuminuria in type 1 diabetes
    • et al
    • Perkins BA, Ficociello LH, Silva KH, et al. Regression of microalbuminuria in type 1 diabetes. N Engl J Med 2003 348 2285-2293
    • (2003) N Engl J Med , vol.348 , pp. 2285-2293
    • Perkins, B.A.1    Ficociello, L.H.2    Silva, K.H.3
  • 5
    • 5444268803 scopus 로고    scopus 로고
    • Remission and regression of diabetic nephropathy
    • Hovind P, Tarnow L, Parving HH. Remission and regression of diabetic nephropathy. Curr Hypertens Rep 2004 6 377-382
    • (2004) Curr Hypertens Rep , vol.6 , pp. 377-382
    • Hovind, P.1    Tarnow, L.2    Parving, H.H.3
  • 6
    • 8344260643 scopus 로고    scopus 로고
    • Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria
    • et al
    • Gaede P, Tarnow L, Vedel P, et al. Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria. Nephrol Dial Transplant 2004 19 2784-2788
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 2784-2788
    • Gaede, P.1    Tarnow, L.2    Vedel, P.3
  • 7
    • 53749091595 scopus 로고    scopus 로고
    • Long-term follow-up after tight control of blood pressure in type 2 diabetes
    • et al
    • Holman RR, Paul SK, Bethel MA, et al. Long-term follow-up after tight control of blood pressure in type 2 diabetes. N Engl J Med 2008 359 1565-1576
    • (2008) N Engl J Med , vol.359 , pp. 1565-1576
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3
  • 8
    • 48149097372 scopus 로고    scopus 로고
    • The kidney in diabetes: Dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007
    • Fioretto P, Caramori ML, Mauer M. The kidney in diabetes: dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007. Diabetologia 2008 51 1347-1355
    • (2008) Diabetologia , vol.51 , pp. 1347-1355
    • Fioretto, P.1    Caramori, M.L.2    Mauer, M.3
  • 9
    • 0142087597 scopus 로고    scopus 로고
    • Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: The Epidemiology of Diabetes Interventions and Complications (EDIC) study
    • Dummy EDIC. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA 2003 290 2159-2167
    • (2003) JAMA , vol.290 , pp. 2159-2167
    • Dummy, E.1
  • 10
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • et al
    • Holman RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008 359 1577-1589
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3
  • 11
    • 3342965156 scopus 로고    scopus 로고
    • GTP-binding protein-independent potentiation by mastoparan of IL-1beta-induced nitric oxide release from insulin-secreting HIT-T15 cells
    • et al
    • Chen HQ, Veluthakal R, Palanivel R, et al. GTP-binding protein-independent potentiation by mastoparan of IL-1beta-induced nitric oxide release from insulin-secreting HIT-T15 cells. Apoptosis 2004 9 145-148
    • (2004) Apoptosis , vol.9 , pp. 145-148
    • Chen, H.Q.1    Veluthakal, R.2    Palanivel, R.3
  • 12
    • 34249934468 scopus 로고    scopus 로고
    • Reactive oxygen species mediate a cellular memory of high glucose stress signalling
    • et al
    • Ihnat MA, Thorpe JE, Kamat CD, et al. Reactive oxygen species mediate a cellular memory of high glucose stress signalling. Diabetologia 2007 50 1523-1531
    • (2007) Diabetologia , vol.50 , pp. 1523-1531
    • Ihnat, M.A.1    Thorpe, J.E.2    Kamat, C.D.3
  • 13
    • 53349101264 scopus 로고    scopus 로고
    • Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    • et al
    • El-Osta A, Brasacchio D, Yao D, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med 2008 205 2409-2417
    • (2008) J Exp Med , vol.205 , pp. 2409-2417
    • El-Osta, A.1    Brasacchio, D.2    Yao, D.3
  • 14
    • 34547611903 scopus 로고    scopus 로고
    • Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy
    • et al
    • Toyoda M, Najafian B, Kim Y, et al. Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy. Diabetes 2007 56 2155-2160
    • (2007) Diabetes , vol.56 , pp. 2155-2160
    • Toyoda, M.1    Najafian, B.2    Kim, Y.3
  • 15
    • 0028556832 scopus 로고
    • Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria
    • Fioretto P, Steffes MW, Mauer M. Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria. Diabetes 1994 43 1358-1364
    • (1994) Diabetes , vol.43 , pp. 1358-1364
    • Fioretto, P.1    Steffes, M.W.2    Mauer, M.3
  • 16
    • 0036068369 scopus 로고    scopus 로고
    • Cellular basis of diabetic nephropathy: 1. Study design and renal structural-functional relationships in patients with long-standing type 1 diabetes
    • et al
    • Caramori ML, Kim Y, Huang C, et al. Cellular basis of diabetic nephropathy: 1. Study design and renal structural-functional relationships in patients with long-standing type 1 diabetes. Diabetes 2002 51 506-513
    • (2002) Diabetes , vol.51 , pp. 506-513
    • Caramori, M.L.1    Kim, Y.2    Huang, C.3
  • 17
    • 0031029379 scopus 로고    scopus 로고
    • Podocyte loss and progressive glomerular injury in type II diabetes
    • et al
    • Pagtalunan ME, Miller PL, Jumping-Eagle S, et al. Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 1997 99 342-348
    • (1997) J Clin Invest , vol.99 , pp. 342-348
    • Pagtalunan, M.E.1    Miller, P.L.2    Jumping-Eagle, S.3
  • 18
    • 0036433059 scopus 로고    scopus 로고
    • Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: Effects of angiotensin converting enzyme inhibition
    • et al
    • Langham RG, Kelly DJ, Cox AJ, et al. Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition. Diabetologia 2002 45 1572-1576
    • (2002) Diabetologia , vol.45 , pp. 1572-1576
    • Langham, R.G.1    Kelly, D.J.2    Cox, A.J.3
  • 19
    • 29144490392 scopus 로고    scopus 로고
    • Podocyte depletion causes glomerulosclerosis: Diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene
    • et al
    • Wharram BL, Goyal M, Wiggins JE, et al. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 2005 16 2941-2952
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2941-2952
    • Wharram, B.L.1    Goyal, M.2    Wiggins, J.E.3
  • 20
    • 33748062325 scopus 로고    scopus 로고
    • Proteinuria with and without renal glomerular podocyte effacement
    • Kalluri R. Proteinuria with and without renal glomerular podocyte effacement. J Am Soc Nephrol 2006 17 2383-2389
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2383-2389
    • Kalluri, R.1
  • 21
    • 62149142105 scopus 로고    scopus 로고
    • Albuminuria, wherefore art thou?
    • Jarad G, Miner JH. Albuminuria, wherefore art thou? J Am Soc Nephrol 2009 20 455-457
    • (2009) J Am Soc Nephrol , vol.20 , pp. 455-457
    • Jarad, G.1    Miner, J.H.2
  • 22
    • 62149122940 scopus 로고    scopus 로고
    • Impaired tubular uptake explains albuminuria in early diabetic nephropathy
    • et al
    • Russo LM, Sandoval RM, Campos SB, et al. Impaired tubular uptake explains albuminuria in early diabetic nephropathy. J Am Soc Nephrol 2009 20 489-494
    • (2009) J Am Soc Nephrol , vol.20 , pp. 489-494
    • Russo, L.M.1    Sandoval, R.M.2    Campos, S.B.3
  • 23
    • 34249901258 scopus 로고    scopus 로고
    • Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy
    • et al
    • Lindenmeyer MT, Kretzler M, Boucherot A, et al. Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy. J Am Soc Nephrol 2007 18 1765-1776
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1765-1776
    • Lindenmeyer, M.T.1    Kretzler, M.2    Boucherot, A.3
  • 24
    • 50249148344 scopus 로고    scopus 로고
    • The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy
    • et al
    • Sato W, Kosugi T, Zhang L, et al. The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy. Lab Invest 2008 88 949-961
    • (2008) Lab Invest , vol.88 , pp. 949-961
    • Sato, W.1    Kosugi, T.2    Zhang, L.3
  • 25
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001 414 813-820
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 26
    • 0344837347 scopus 로고    scopus 로고
    • Benfotiamine blocks 3 major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
    • et al
    • Hammes HP, Du X, Edelstein D, et al. Benfotiamine blocks 3 major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med 2003 9 294-299
    • (2003) Nat Med , vol.9 , pp. 294-299
    • Hammes, H.P.1    Du, X.2    Edelstein, D.3
  • 27
    • 17744364508 scopus 로고    scopus 로고
    • Effects of NADPH oxidase inhibitor in diabetic nephropathy
    • et al
    • Asaba K, Tojo A, Onozato ML, et al. Effects of NADPH oxidase inhibitor in diabetic nephropathy. Kidney Int 2005 67 1890-1898
    • (2005) Kidney Int , vol.67 , pp. 1890-1898
    • Asaba, K.1    Tojo, A.2    Onozato, M.L.3
  • 28
    • 40749139536 scopus 로고    scopus 로고
    • Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway
    • et al
    • Thallas-Bonke V, Thorpe SR, Coughlan MT, et al. Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway. Diabetes 2008 57 460-469
    • (2008) Diabetes , vol.57 , pp. 460-469
    • Thallas-Bonke, V.1    Thorpe, S.R.2    Coughlan, M.T.3
  • 29
    • 0030483886 scopus 로고    scopus 로고
    • Oxidative stress caused by glycation of Cu,Zn-superoxide dismutase and its effects on intracellular components
    • et al
    • Fujii J, Myint T, Okado A, et al. Oxidative stress caused by glycation of Cu,Zn-superoxide dismutase and its effects on intracellular components. Nephrol Dial Transplant 1996 11 34-40
    • (1996) Nephrol Dial Transplant , vol.11 , pp. 34-40
    • Fujii, J.1    Myint, T.2    Okado, A.3
  • 30
    • 27744453362 scopus 로고    scopus 로고
    • Understanding RAGE, the receptor for advanced glycation end products
    • et al
    • Bierhaus A, Humpert PM, Morcos M, et al. Understanding RAGE, the receptor for advanced glycation end products. J Mol Med 2005 83 876-886
    • (2005) J Mol Med , vol.83 , pp. 876-886
    • Bierhaus, A.1    Humpert, P.M.2    Morcos, M.3
  • 32
    • 34247399855 scopus 로고    scopus 로고
    • Association between glycosylated hemoglobin level and 16-year incidence of chronic kidney disease in type 1 diabetes
    • et al
    • Shankar A, Klein R, Klein BE, et al. Association between glycosylated hemoglobin level and 16-year incidence of chronic kidney disease in type 1 diabetes. Exp Clin Endocrinol Diabetes 2007 115 203-206
    • (2007) Exp Clin Endocrinol Diabetes , vol.115 , pp. 203-206
    • Shankar, A.1    Klein, R.2    Klein, B.E.3
  • 33
    • 65249153029 scopus 로고    scopus 로고
    • RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes
    • et al
    • Coughlan MT, Thorburn DR, Penfold SA, et al. RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. J Am Soc Nephrol 2009 20 742-752
    • (2009) J Am Soc Nephrol , vol.20 , pp. 742-752
    • Coughlan, M.T.1    Thorburn, D.R.2    Penfold, S.A.3
  • 35
    • 0037377697 scopus 로고    scopus 로고
    • RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy
    • et al
    • Wendt TM, Tanji N, Guo J, et al. RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Am J Pathol 2003 162 1123-1137
    • (2003) Am J Pathol , vol.162 , pp. 1123-1137
    • Wendt, T.M.1    Tanji, N.2    Guo, J.3
  • 36
    • 41749118714 scopus 로고    scopus 로고
    • Renal toxicity mediated by glucose degradation products in a rat model of advanced renal failure
    • et al
    • Muller-Krebs S, Kihm LP, Zeier B, et al. Renal toxicity mediated by glucose degradation products in a rat model of advanced renal failure. Eur J Clin Invest 2008 38 296-305
    • (2008) Eur J Clin Invest , vol.38 , pp. 296-305
    • Muller-Krebs, S.1    Kihm, L.P.2    Zeier, B.3
  • 37
    • 0037455982 scopus 로고    scopus 로고
    • Genotoxicity of advanced glycation end products in mammalian cells
    • et al
    • Stopper H, Schinzel R, Sebekova K, et al. Genotoxicity of advanced glycation end products in mammalian cells. Cancer Lett 2003 190 151-156
    • (2003) Cancer Lett , vol.190 , pp. 151-156
    • Stopper, H.1    Schinzel, R.2    Sebekova, K.3
  • 38
    • 65249153029 scopus 로고    scopus 로고
    • RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes
    • et al
    • Coughlan MT, Thorburn DR, Penfold SA, et al. RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. J Am Soc Nephrol 2009 20 742-752
    • (2009) J Am Soc Nephrol , vol.20 , pp. 742-752
    • Coughlan, M.T.1    Thorburn, D.R.2    Penfold, S.A.3
  • 39
    • 33847078388 scopus 로고    scopus 로고
    • Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation
    • et al
    • Usui HK, Shikata K, Sasaki M, et al. Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. Diabetes 2007 56 363-372
    • (2007) Diabetes , vol.56 , pp. 363-372
    • Usui, H.K.1    Shikata, K.2    Sasaki, M.3
  • 40
    • 0036895708 scopus 로고    scopus 로고
    • Activation of tubular epithelial cells in diabetic nephropathy
    • et al
    • Morcos M, Sayed AA, Bierhaus A, et al. Activation of tubular epithelial cells in diabetic nephropathy. Diabetes 2002 51 3532-3544
    • (2002) Diabetes , vol.51 , pp. 3532-3544
    • Morcos, M.1    Sayed, A.A.2    Bierhaus, A.3
  • 41
    • 59849100342 scopus 로고    scopus 로고
    • Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells
    • et al
    • Morcos M, Schlotterer A, Sayed AA, et al. Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells. Horm Metab Res 2008 40 752-759
    • (2008) Horm Metab Res , vol.40 , pp. 752-759
    • Morcos, M.1    Schlotterer, A.2    Sayed, A.A.3
  • 42
    • 0035661067 scopus 로고    scopus 로고
    • Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)
    • et al
    • Oldfield MD, Bach LA, Forbes JM, et al. Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). J Clin Invest 2001 108 1853-1863
    • (2001) J Clin Invest , vol.108 , pp. 1853-1863
    • Oldfield, M.D.1    Bach, L.A.2    Forbes, J.M.3
  • 43
    • 56049094602 scopus 로고    scopus 로고
    • The effects of rosiglitazione on renal artery endothelium in diabetic rats
    • et al
    • Lu YL, Jimbu YM, Chen Y, et al. The effects of rosiglitazione on renal artery endothelium in diabetic rats. Exp Clin Endocrinol Diabetes 2008 116 537-540
    • (2008) Exp Clin Endocrinol Diabetes , vol.116 , pp. 537-540
    • Lu, Y.L.1    Jimbu, Y.M.2    Chen, Y.3
  • 44
    • 0036786046 scopus 로고    scopus 로고
    • Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: Biochemical mechanisms
    • et al
    • Miyata T, Van Ypersele De SC, Ueda Y, et al. Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms. J Am Soc Nephrol 2002 13 2478-2487
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2478-2487
    • Miyata, T.1    Van Ypersele De, S.C.2    Ueda, Y.3
  • 45
    • 70349582699 scopus 로고    scopus 로고
    • ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats
    • et al
    • Sun HL, Sun L, Li YY, et al. ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats. Exp Clin Endocrinol Diabetes 2009 117 336-344
    • (2009) Exp Clin Endocrinol Diabetes , vol.117 , pp. 336-344
    • Sun, H.L.1    Sun, L.2    Li, Y.Y.3
  • 46
    • 4444374983 scopus 로고    scopus 로고
    • Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor
    • et al
    • Kakoki M, Takahashi N, Jennette JC, et al. Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proc Natl Acad Sci USA 2004 101 13302-13305
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13302-13305
    • Kakoki, M.1    Takahashi, N.2    Jennette, J.C.3
  • 47
    • 35348857529 scopus 로고    scopus 로고
    • ACE inhibitor reduces growth factor receptor expression and signaling but also albuminuria through B2-kinin glomerular receptor activation in diabetic rats
    • et al
    • Allard J, Buleon M, Cellier E, et al. ACE inhibitor reduces growth factor receptor expression and signaling but also albuminuria through B2-kinin glomerular receptor activation in diabetic rats. Am J Physiol Renal Physiol 2007 293 F1083-F1092
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Allard, J.1    Buleon, M.2    Cellier, E.3
  • 48
    • 68249129012 scopus 로고    scopus 로고
    • Kallikrein protects against microalbuminuria in experimental type i diabetes
    • et al
    • Bodin S, Chollet C, Goncalves-Mendes N, et al. Kallikrein protects against microalbuminuria in experimental type I diabetes. Kidney Int 2009 76 395-403
    • (2009) Kidney Int , vol.76 , pp. 395-403
    • Bodin, S.1    Chollet, C.2    Goncalves-Mendes, N.3
  • 49
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): A multicentre, randomised, double-blind, controlled trial
    • et al
    • Mann JF, Schmieder RE, McQueen M, et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 2008 372 547-553
    • (2008) Lancet , vol.372 , pp. 547-553
    • Mann, J.F.1    Schmieder, R.E.2    McQueen, M.3
  • 50
    • 13344293711 scopus 로고    scopus 로고
    • Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor
    • et al
    • Ishii H, Jirousek MR, Koya D, et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 1996 272 728-731
    • (1996) Science , vol.272 , pp. 728-731
    • Ishii, H.1    Jirousek, M.R.2    Koya, D.3
  • 51
    • 64149092195 scopus 로고    scopus 로고
    • Targeting the protein kinase C family in the diabetic kidney: Lessons from analysis of mutant mice
    • Meier M, Menne J, Haller H. Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice. Diabetologia 2009 52 765-775
    • (2009) Diabetologia , vol.52 , pp. 765-775
    • Meier, M.1    Menne, J.2    Haller, H.3
  • 52
    • 34047235730 scopus 로고    scopus 로고
    • Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo
    • et al
    • Meier M, Menne J, Park JK, et al. Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo. J Am Soc Nephrol 2007 18 1190-1198
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1190-1198
    • Meier, M.1    Menne, J.2    Park, J.K.3
  • 53
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • et al
    • Sharma K, Jin Y, Guo J, et al. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 1996 45 522-530
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3
  • 54
    • 0034608948 scopus 로고    scopus 로고
    • Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
    • et al
    • Ziyadeh FN, Hoffman BB, Han DC, et al. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc Natl Acad Sci USA 2000 97 8015-8020
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8015-8020
    • Ziyadeh, F.N.1    Hoffman, B.B.2    Han, D.C.3
  • 55
    • 36649011357 scopus 로고    scopus 로고
    • Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model
    • et al
    • Ohtomo S, Izuhara Y, Takizawa S, et al. Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model. Kidney Int 2007 72 1512-1519
    • (2007) Kidney Int , vol.72 , pp. 1512-1519
    • Ohtomo, S.1    Izuhara, Y.2    Takizawa, S.3
  • 56
    • 33645450441 scopus 로고    scopus 로고
    • Enhancing the predictive value of urinary albumin for diabetic nephropathy
    • Caramori ML, Fioretto P, Mauer M. Enhancing the predictive value of urinary albumin for diabetic nephropathy. J Am Soc Nephrol 2006 17 339-352
    • (2006) J Am Soc Nephrol , vol.17 , pp. 339-352
    • Caramori, M.L.1    Fioretto, P.2    Mauer, M.3


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