Immunological diagnosis of tuberculosis based on recombinant antigens ESAT-6 and CFP-10 in children from an endemic area in Northeast Brazil

Scandinavian Journal of Immunology

Volumn 72, Issue 5, 2010, Pages 460-468

  Van Lume, D S M ^a   de Souza, J R ^a   Cabral, M M L ^b   Rego, J C ^c   Balbino, V ^b   Saad, M H ^a   Schindler, H C ^a,b   Abath, F G C ^a   Montenegro, S M L ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c Fernando Figueira Institute of Mother and Child   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CULTURE FILTRATE PROTEIN 10; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; TUBERCULIN;

ANTIGEN PRESENTATION; ARTICLE; BLOOD CULTURE; BRAZIL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE FILTRATE PROTEIN 10 TEST; CYTOKINE RELEASE; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; EARLY SECRETORY ANTIGENIC TARGET 6 TEST; ENDEMIC DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOLOGICAL TECHNIQUE; IN VITRO STUDY; INTERMETHOD COMPARISON; MALE; PRIORITY JOURNAL; SCHOOL CHILD; TUBERCULIN TEST; TUBERCULOSIS;

ADOLESCENT; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BRAZIL; CHILD; CHILD, PRESCHOOL; ENDEMIC DISEASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERFERON-GAMMA; MALE; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; T-LYMPHOCYTES; TUBERCULOSIS;

EID: 77958093599     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2010.02459.x     Document Type: Article

References (53)

1. World Health Organization. WHO Report 2008: Global Tuberculosis Control. Surveillance, Planning, Financing, 2008: pp. 304.
2. Cardona PJ, Ruiz-Manzano J. On the nature of Mycobacterium tuberculosis-latent bacilli. Eur Respir J 2004;24:1044-51.
3. Gil O, Diaz I, Vilaplana C. Granuloma encapsulation is a key factor for containing tuberculosis infection in minipigs. PLoS ONE 2010;5:e10030.
4. Flynn JL, Chan J. Immunology of tuberculosis. Annu Rev Immunol 2001;19:93-129.
5. Wiker HG, Mustafa T, Bjune GA, Harboe M. Evidence for warning of latency in a cohort study of tuberculosis. BMC Infect Dis 2010;10:37.
6. Van-Lume DSM, Souza JR, Melo WG et al. Preliminary results in the immunodiagnosis of tuberculosis in children based on the T cell response to ESAT-6 and PPD antigens. Mem Inst Oswaldo Cruz 2008;103:401-4.
7. Bergamini BM, Losi M, Vaienti F et al. Performance of commercial blood tests for the diagnosis of latent tuberculosis infection in children and adolescents. Pediatrics 2009;123:e419-24.
8. Khan EA, Starke JR. Diagnosis of tuberculosis in children: increased need for better methods. Emerg Infect Dis 1995;1:115-23.
9. Jasmer RM, Nahid P, Hopewell PC. Clinical practice. Latent tuberculosis infection. New Engl J Med 2002;347:1860-6.
10. Tufariello JM, Chan J, Flynn JL. Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection. Lancet Infect Dis 2003;3:578-90.
11. Cardona PJ. A dynamic reinfection hypothesis of latent tuberculosis infection. Infection 2009;37:80-6.
12. Higuchi K, Kawabe Y, Mitarai S, Yoshiyama T, Harada N, Mori T. Comparison of performance in two diagnostic methods for tuberculosis infection. Med Microbiol Immunol 2009;198:33-7.
13. Arend SM, Franken W, Aggerbeck H et al. Double-blind randomized Phase I study comparing rdESAT-6 to tuberculin as skin test reagent in the diagnosis of tuberculosis infection. Tuberculosis 2008;88:249-61.
14. Menzies RI. Tuberculin skin testing. In: Reichman LB, Hershfield ES, eds. Tuberculosis, a Comprehensive International Approach. New York: Marcel Dekker, 2000:279-322, ISBN: 978-0824781217.
15. Scarpellini P, Tasca S, Galli L, Beretta A, Lazzarin A, Fortis C. Selected pool of peptides from ESAT-6 and CFP-10 proteins for detection or Mycobacterium tuberculosis infection. J Clin Microbiol 2004;42:3469-74.
16. Sant'Anna CC, Mourgues LV, Ferrero F, Balanzar AM. Diagnóstico e terapêutica da tuberculose infantil - uma vis ão atualizada de um antigo problema. J Pediatr (Rio J) 2002;78:205-14.
17. Kunst H. Diagnosis of latent tuberculosis infection: the potential role of new technologies. Respir Med 2006;100:2098-106.
18. Teixeira HC, Abramo C, Munk ME. Diagnóstico imunológico da tuberculose: problemas e estratégias para o sucesso. J Bras Pneumol 2007;33:323-34.
19. Pai M, O'brien R. New diagnostics for latent and active tuberculosis: state of the art and future prospects. Semin Respir Crit Care Med 2008;29:560-8.
20. Pai M, Riley LW, Colford JM. Interferon-Γ assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis 2004;4:761-76.
21. Munk ME, Arend SM, Brock I, Ottenhoff THM, Andersen P. Use of ESAT-6 and CFP-10 antigens for diagnosis of extrapulmonary tuberculosis. J Infect Dis 2001;183:175-6.
22. Lalvani A, Millington KA. T-cell interferon-gamma release assays: Can we do better? Eur Respir J 2008;32:1428-30.
23. Perio MA, Tsevat J, Roselle GA, Kralovic SM, Eckman MH. Cost-effectiveness of Interferon Gamma release assays vs Tuberculin skin tests in health care workers. Arch Intern Med 2009;169:179-87.
24. Pai M, Kalantri S, Dheda K. New tools and emerging technologies for the diagnosis of tuberculosis: part I. Latent tuberculosis. Expert Rev Mol Diagn 2006;6:413-22.
25. Menzies D, Pai M, Comstock G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med 2007;146:340-4.
26. Tavares RCO, Salgado J, Moreira VB et al. Improvement of interferon-gamma response to the combinations of 38kDa/CFP10, 38kDa/MPT-64, ESAT-6/MPT-64, CFP-10/ESAT-6 related to each single recombinants proteins of Mycobacterium tuberculosis in individuals from endemic area for tuberculosis. J Microbiol Immunol 2007;51:289-96.
27. Newton SM, Brent AJ, Anderson S, Whittaker E, Kampmann B. Paediatric tuberculosis. Lancet Infect Dis 2008;8:498-510.
28. Pai M, Zwerling A, Menzies D. Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Ann Intern Med 2008;149:177-84.
29. American Thoracic Society. Diagnostic standards and classification of tuberculosis in adult and children. Am J Respir Crit Care Med 2000;161:1376-95.
30. Sackett DL, Haynes RB, Guyatt GH, Tugwell P. Clinical Epidemiology: A Basic Science for Clinical Medicine. Boston: Little, Brown, 1991, ISBN: 978-0316765992.
31. Marais BJ, Pai M. Recent advances in the diagnosis of childhood tuberculosis. Arch Dis Child 2007;92:446-52.
32. Connel TG, Curtis N, Ranganathan SC, Buttery JP. Performance of a whole blood interferon gamma assay for detecting latent infection with Mycobacterium tuberculosis in children. Thorax 2006;1:616-20.
33. Starke JR, Ong L, Eisenach K. Detection of M. tuberculosis in gastric aspirate samples from children using polymerase chain reaction. Am Rev Respir Dis 1993;147:A801.
34. Schaaf HS, Michaelis IA, Richardson M et al. Adult to child transmission of tuberculosis: household or community contact? Int J Tuberc Lung Dis 2003;7:426-31.
35. Comstock GW. False tuberculin test results. Chest 1975;8:465-9.
36. Karam F, Mbow F, Fletcher H et al. Sensitivity of IFN-Γ release assay to detect latent tuberculosis infection is retained in HIV-infected patients but dependent on HIV/AIDS progression. Public Library of Science 2008;1:e1441.
37. Nakaoka H, Lawson L, Squire SB et al. Risk for tuberculosis among children. Emer Infect Dis 2006;12:1383-8.
38. Nishimura T, Hasegawa N, Mori M et al. Accuracy of an interferon-gamma release assay to detect active pulmonary and extra-pulmonary tuberculosis. Inter. J Tuberc Lung Dis 2008;12:269-74.
39. Arend SM. Antigenic equivalence of human T-Cell responses to Mycobacterium tuberculosis- specific RD-1 encoded protein antigens ESAT-6 and CFP-10 and to mixtures of synthetic peptides. Infec and Immunity 2000;68:3314-21.
40. Arend SM, Andersen P, Meijgaarden K etal. Detection of active tuberculosis infection by T cell responses to early-secreted antigenic targert 6-kDa protein and culture filtrate protein 10. J Infect Dis 2000;181:1850-4.
41. Brock I, Ruhwald M, Lundgren B, Westh H, Mathiesen LR, Ravn P. Performance of whole blood IFN- test for tuberculosis diagnosis based on PPD or the specific antigens ESAT-6 and CFP-10. Int J Tuberc Lung Dis 2001;5:462-7.
42. Ravn P. Prospective evolution of a whole-blood test using Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10 for diagnosis active tuberculosis. Clin Diag Lab Immunol 2005;12:491-6.
43. Van Pinxteren LAH, Ravn P, Agger E, Pollock J, Andersen P. Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP-10. Clin Diag Lab Immunol 2000;7:155-60.
44. Mori T. Specific detection of tuberculosis infection: an interferon-Γ based assay using new antigens. Am J Respir Critic Care Med 2004;170:59-64.
45. Ravn P, Demissie A, Eguale T et al. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J Infect Dis 1999;179:637-45.
46. Soysal A, Torun T, Efe S, Gencer H, Tahaoglu K, Balkir M. Evaluation of cut-off values of interferon-gamma-based assays in the diagnosis of M.tuberculosis infection. Int J Tuberc Lung Dis 2008;12:50-6.
47. Hill PC, Jackson-Sillah D, Fox A etal. Esat-6/CFP-10 fusion protein and peptides for optimal diagnosis of Mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in the Gambia. J Clin Microbiol 2005;43:2070-4.
48. Selvaraj P, Uma H, Reetha AM, Xavier T, Prabhakar R, Narayanan PR. Influence of HLA-DR2 phenotype on humoral immunity and lymphocyte response to Mycobacterium tuberculosis culture filtrate antigens in pulmonary tuberculosis. Indian J Med Res 1998;107:208-17.
49. Mollenkopf HJ, Grode L, Mattow J et al. Application of mycobacterial proteomics to vaccine design: improved protection by Mycobacterium bovis BCG prime-RV3407 DNA boost vaccination against tuberculosis. Infect Immun 2004;72:6471-9.
50. Wu Y, Woodworth JS, Shin DS, Morris S, Behar SM. Vaccine-elicited 10-kilodalton culture filtrate protein-specific CD8+ T cells are sufficient to mediate protection against Mycobacterium tuberculosis infection. Infect Immun 2008;76:2249-55.
51. Mustafa AS, Cockle PJ, Shaban F, Hewinson RG, Vordermeier HM. Immunogenicity of Mycobacterium tuberculosis RD1 region gene products in infected cattle. Clin Exp Immunol 2002;130:37-42.
52. Meher AK, Bal NC, Chary KV, Arora A. Mycobacterium tuberculosis H37Rv ESAT-6-CFP-10 complex formation confers thermodynamic and biochemical stability. FEBS J 2006;273:1445-62.
53. De Jonge MI, Pehau-Arnaudet G, Fretz MM et al. ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. J Bacteriol 2007;189:6028-34.