Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6426-6429

  Yewalkar, Nilambari ^a   Deore, Vijaykumar ^a   Padgaonkar, Amol ^a   Manohar, Sonal ^a   Sahu, Bichismita ^a   Kumar, Pramod ^a   Jalota Badhwar, Archana ^a   Joshi, Kalpana S ^a   Sharma, Somesh ^a   Kumar, Sanjay ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Anticancer; Antiproliferative; Drug discovery; HIF 1 ; Hypoxia; Pyridylpyrimidine; Small molecule

Indexed keywords

ANTINEOPLASTIC AGENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; P 2630; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; COLON CANCER; CONTROLLED STUDY; DRUG TARGETING; GLIOBLASTOMA; IC 50; MOUSE; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PROSTATE CANCER; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELLS, CULTURED; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, SCID;

MUS;

EID: 77958063983     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.083     Document Type: Article

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21. 2 332.0288; found: 333.0361 (M+H); HPLC purity 99.88%.