Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6680-6684

  Bandyopadhyaya, Achintya K ^a   Manion, Brad D ^b   Benz, Ann ^b   Taylor, Amanda ^b   Rath, Nigam P ^c   Evers, Alex S ^a,b   Zorumski, Charles F ^a,b   Mennerick, Steven ^a,b   Covey, Douglas F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF MISSOURI ST LOUIS   (United States)

Author keywords

Alphaxalone; Anesthetic steroid; Delta 16 alphaxalone; GABAA receptor; Tadpole anesthesia; TBPS binding

Indexed keywords

17 CARBONITRILE; ALFAXALONE; DELTA 16 ALPHAXALONE; NEUROSTEROID; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CHROMATOGRAPHY; COMPARATIVE STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; TADPOLE;

ANESTHETICS; ANIMALS; CRYSTALLOGRAPHY, X-RAY; GAMMA-AMINOBUTYRIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NITRILES; PREGNANEDIONES; RATS; SPECTROPHOTOMETRY, INFRARED;

EID: 77958049931     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.008     Document Type: Article

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