Receptor activity-modifying protein-1 augments cerebrovascular responses to calcitonin gene-related peptide and inhibits angiotensin II-induced vascular dysfunction

Stroke

Volumn 41, Issue 10, 2010, Pages 2329-2334

  Chrissobolis, Sophocles ^a   Zhang, Zhongming ^a   Kinzenbaw, Dale A ^a   Lynch, Cynthia M ^a   Russo, Andrew F ^a   Faraci, Frank M ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

adrenomedullin; basilar artery; calcitonin gene related peptide; carotid artery; cerebral circulation; microcirculation; oxidative stress; receptor activity modifying protein

Indexed keywords

ACETYLCHOLINE; ANGIOTENSIN II; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; SUPEROXIDE; MEMBRANE PROTEIN; RAMP1 PROTEIN, HUMAN; RAMP1 PROTEIN, MOUSE; RECEPTOR ACTIVITY MODIFYING PROTEIN; SIGNAL PEPTIDE;

ANIMAL TISSUE; ARTERIOLE; ARTICLE; BASILAR ARTERY; CAROTID ARTERY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE; VASCULAR DISEASE; ANIMAL; DRUG EFFECTS; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM; VASODILATATION;

ANGIOTENSIN II; ANIMALS; BASILAR ARTERY; CALCITONIN GENE-RELATED PEPTIDE; CAROTID ARTERIES; ENDOTHELIUM, VASCULAR; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VASODILATION; RECEPTOR ACTIVITY-MODIFYING PROTEIN 1; RECEPTOR ACTIVITY-MODIFYING PROTEINS;

EID: 77958022914     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.589648     Document Type: Article

References (36)

1. Brain SD, Grant AD. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev. 2004;84:903-934.
2. + channels in CGRP-induced dilatation of basilar artery in vivo. Am J Physiol. 1993;265:H581-H585. (Pubitemid 23273594)
3. Sams A, Knyihar-Csillik E, Engberg J, Szok D, Tajti J, Bodi I, Edvinsson L, Vecsei L, Jansen-Olesen I. CGRP and adrenomedullin receptor populations in human cerebral arteries: in vitro pharmacology and molecular investigations in different artery sizes. Eur J Pharmacol. 2000;408: 183-193.
4. Jansen I, Alafaci C, Uddman R, Edvinsson L. Evidence that calcitonin gene-related peptide contributes to the capsaicin-induced relaxation of guinea pig cerebral arteries. Reg Pep. 1990;31:167-178.
5. Busija DW, F Bari, F Domoki, T Horiguchi, K Shimizu. Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression. Progress Neurobiol. 2008;86:379-395.
6. Shin HK, Hong KW. Importance of calcitonin gene-related peptide, adenosine and reactive oxygen species in cerebral autoregulation under normal and diseased conditions. Clin Exper Pharmacol Physiol. 2004; 31:1-7.
7. Toyoda K, Faraci FM, Watanabe Y, Ueda T, Andresen JJ, Chu Y, Otake S, Heistad DD. Gene transfer of calcitonin gene-related peptide prevents vasoconstriction after subarachnoid hemorrhage Circulation Res. 2000; 87:818-824.
8. Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W, Muff R, Fisher JA, Foord SM. International union of pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacological Rev. 2002;54: 233-246.
9. Tsujikawa K, Yayama K, Hayashi T, Matsushita H, Yamaguchi T, Shigeno T, Ogitani Y, Hirayama M, Kato T, Fukada S, Takatori S, Kawasaki H, Okamoto H, Ikawa M, Okabe M, Yamamoto H. Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice. Proc Natl Acad Sci. 2007;104:16702-16707.
10. Zhang Z, Dickerson IM, Russo AF. Calcitonin gene-related peptide receptor activation by receptor activity-modifying protein-1 gene transfer to vascular smooth muscle cells. Endocrinology. 2006;147:1932-1940.
11. Sabharwal R, Zhang Z, Lu Y, Abboud FM, Russo AF, Chapleau MW. Receptor activity-modifying protein-1 increases baroreflex sensitivity and attenuates angiotensin-induced hypertension. Hypertension. 2010;55: 627-635.
12. Modrick ML, Didion SP, Sigmund CD, Faraci FM. Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. Am J Physiol. 2009;296:H1914-H1919.
13. Reckelhoff JF, Romero JC. Role of oxidative stress in angiotensin-induced hypertension. Am J Physiol. 2003;284:R893-R912.
14. Chrissobolis S, Didion SP, Kinzenbaw DA, Schrader LI, Dayal S, Lentz SR, Faraci FM. Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction. Hypertension. 2008; 51:872-877.
15. Kazama K, Anrather J, Zhou P, Girouard H, Frys K, Milner TA, Iadecola C. Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circulation Res. 2004;95:1019-1026.
16. Liu J, Shimosawa T, Matsui H, Meng F, Supowit SC, DiPette DJ, Ando K, Fujita T. Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity. Am J Physiol. 2007; 292:H1714-H721.
17. Schaeffer C, Vandroux D, Thomassin L, Athias P, Rochette L, Connat JL. Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress via activation of ERK1/2 MAPK. Biochim Biophys Acta. 2003;1643:65-73.
18. Yoshimoto T, Gochou N, Fukai N, Sugiyama T, Shichiri M, Hirata Y. Adrenomedullin inhibits angiotensin II-induced oxidative stress and gene expression in rat endothelial cells. Hypertension Res. 2005;28:165-172. (Pubitemid 40663068)
19. Zhang Z, Winborn CS, Marquez de Prado B, Russo AF. Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion. J Neurosci. 2007;27:2693-2703.
20. Sobey CG, Faraci FM. Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles. Stroke. 1997;28:837-842.
21. Wang W, Sun W, Wang X. Intramuscular gene transfer of CGRP inhibits neointimal hyperplasia after balloon injury in the rat abdominal aorta. Am J Physiol. 2004;287:H1582-H1589.
22. Ye F, P-Y Deng, D Li, D Luo, N-S Li, S Deng, H-W Deng, Y-J Li. Involvement of endothelial cell-derived CGRP in heat stress-induced protection of endothelial function. Vascular Pharmacol. 2007;46: 238-246.
23. Aukes AM, Bishop N, Godfrey J, Cipolla MJ. The influence of pregnancy and gender on perivascular innervation of rat posterior cerebral arteries. Reprod Sci. 2008;15:411-419.
24. Ashton D, Hieble P, Gout B, Aiyar N. Vasodilatory effect of adrenomedullin in mouse aorta. Pharmacology. 2000;61:101-105.
25. Hay DL, Poyner DR, Quirion R. International union of pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor. Pharmacol Rev. 2008;60:143-145.
26. Tam CW, Husmann K, Clark NC, Clark JE, Lazar Z, Ittner LM, Gotz J, Douglas G, Grant AD, Sudgen D, Poston L, Poston R, McFadzean I, Marber MS, Fisher JA, Born W, Brain SD. Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2. Circulation Res. 2009;98:262-270.
27. Villalon CM, Olesen J. The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs. Pharmacol Ther. 2009;124:309-323.
28. Brian JE Jr, Heistad DD, Faraci FM. Mechanisms of endotoxin-induced dilatation of cerebral arterioles. Am J Physiol. 1995;269:H783-H788.
29. Hay DL, Poyner DR, Sexton PM. GPCR modulation by RAMPs. Pharmacol Ther. 2006;109:173-197.
30. Dong YL, Green KE, Vegiragu S, Hankins GD, Martin E, Chauhan M, Thota C, Yallampalli C. Evidence for decreased calcitonin gene-related peptide (CGRP) receptors and compromised resonsiveness to CGRP of fetoplacental vessels in preeclamptic prenancies. J Clin Endocrinol Metab. 2005;90:2336-2343.
31. Cuielle C, Birot O, Bigard X, Hagner S, Garel J-M. Post-transcriptional regulation of CRLR expression during hypoxia. Biochem Biophys Res Comm. 2004;326:23-29.
32. Nagae T, Mukoyama N, Sugawara A, Mori K, Yahata K, Kasahara M, Suganami T, Makino H, Fujinaga Y, Yoshioka T, Tanaka I, Nakao K. Rat receptor-activity- modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: Cloning and upregulation in obstructive nephropathy. Biochem Biophys Res Comm. 2000;270:89-93.
33. Baumbach GL, Sigmund CD, Faraci FM. Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. Hypertension. 2003;41:50-55.
34. Chrissobolis S, Faraci FM. Role of oxidative stress and NADPH oxidase in cerebrovascular disease. Trends Molecular Med. 2008;14:495-502.
35. Qin XP, Ye F, Hu CP, Liao DF, Deng HW, Li YJ. Effect of calcitonin gene-related peptide on angiotensin II-induced proliferation of rat vascular smooth muscle cells. Eur J Pharmacol. 2004;488:45-49.
36. Liang L, Tam CW, Pozsgai G, Siow R, Clark N, Keeble J, Husmann K, Born W, Fischer JA, Poston R, Shah A, Brain SD. Protection of angiotensin II-induced vascular hypertrophy in vascular smooth muscle-targeted receptor activity-modifying protein 2 transgenic mice. Hypertension. 2009;54:1254-1261.