CGRP and adrenomedullin receptor populations in human cerebral arteries: In vitro pharmacological and molecular investigations in different artery sizes

European Journal of Pharmacology

Volumn 408, Issue 2, 2000, Pages 183-193

  Sams, Anette ^a   Knyihár Csillik, Elizabeth ^b   Engberg, Jan ^a   Szok, Délia ^b   Tajti, János ^b   Bodi, István ^b   Edvinsson, Lars ^c   Vécsei, László ^b   Jansen Olesen, Inger ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF SZEGED   (Hungary)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adrenomedullin; CGRP (calcitonin gene related peptide); CRLR (calcitonin receptor like receptor); Human; Lenticulostriate artery; RAMP (receptor activity modifying protein); RT PCR

Indexed keywords

ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; MESSENGER RNA; PROTEIN DERIVATIVE; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; BRAIN ARTERY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL;

ADRENOMEDULLIN; CALCITONIN GENE-RELATED PEPTIDE; CEREBRAL ARTERIES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MIDDLE CEREBRAL ARTERY; PEPTIDES; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RECEPTORS, PEPTIDE; RNA, MESSENGER; VASOCONSTRICTION; VASODILATION; VASODILATOR AGENTS;

EID: 0034680842     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00781-0     Document Type: Article

References (46)

1. Development of calcitonin gene-related peptide slow-release tablet implanted in CSF space for prevention of cerebral vasospasm after experimental subarachnoid haemorrhage
2. A cDNA encoding the calcitonin gene-related peptide type 1 receptor
3. Sumatriptan inhibits the release of CGRP and substance P from the rat spinal cord
4. Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks
5. A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1
6. CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissues
7. Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity
8. HCGRP-8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery
9. Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist
10. 2 in vitro bioassays
11. Calcitonin gene-related peptide and cerebral blood vessels: Distribution and vasomotor effects
12. Comparison of peptidergic mechanisms in different parts of the guinea pig superior mesenteric artery: Immunocytochemistry at the light and ultrastructural levels and responses in vitro of large and small arteries
13. Reduced levels of calcitonin gene-related peptide-like immunoreactivity in human brain vessels after subarachnoid haemorrhage
14. Expression of calcitonin gene-related peptide1 receptor mRNA in human trigeminal ganglia and cerebral arteries
15. Clinical perspectives of calcitonin gene related peptide pharmacology
16. Differential vasodilator profile of calcitonin gene-related peptide in porcine large and small diameter coronary artery rings
17. The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
18. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
19. Calcitonin gene-related peptide is present in mammalian cerebrovascular nerve fibres and dilates pial and peripheral arteries
20. Distribution and effects of neuropeptide Y, vasoactive intestinal peptide, substance P, and calcitonin gene-related peptide in human middle meningeal arteries: Comparison with cerebral and temporal arteries
21. Calcitonin gene-related peptide (human alpha-CGRP) counteracts vasoconstriction in human subarachnoid haemorrhage
22. Receptors for adrenomedullin in human vascular endothelial cells
23. Increased plasma concentration of adrenomedullin in patients with subarachnoid hemorrhage
24. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
25. Depletion of calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat after electrical stimulation of the Gasserian ganglion
26. Mechanisms of adrenomedullin-induced dilatation of cerebral arterioles
27. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
28. Calcitonin gene-related peptide (CGRP) induces more potent vasorelaxation in the resistance portion than in the conduit portion of mesenteric arteries in humans
29. Functional calcitonin gene-related peptide type 1 and adrenomedullin receptors in human trigeminal ganglia, brain vessels, and cerebromicrovascular or astroglial cells in culture
30. Effects of adrenomedullin on rat cerebral arterioles
31. Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: Homologous peptides, separate receptors and overlapping biological actions
32. Receptor activity modifying proteins regulate the activity of a calcitonin gene-related peptide receptor in rabbit aortic endothelial cells
33. Amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3
34. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats
35. Changes of calcitonin gene-related peptide-like immunoreactivity in cerebrovascular nerve fibers in the dog after experimentally produced subarachnoid hemorrhage
36. Pharmacology of receptors for calcitonin gene-related peptide and amylin
37. 2 receptor subtypes
38. Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries
39. Caliber dependent calcitonin gene-related peptide-induced relaxation in rat coronary arteries: Effect of K+ on the tachyphylaxis
40. Effect of subarachnoid hemorrhage on dilatation of rat basilar artery in vivo
41. Endothelial cells actively synthesize and secrete adrenomedullin
42. Production and secretion of adrenomedullin from vascular smooth muscle cells: Augmented production by tumor necrosis factor-alpha
43. Messenger molecules and receptor mRNA in the human trigeminal ganglion
44. Innervation of the feline cerebral vascul ature by nerve fibers containing calcitonin gene-related peptide: Trigeminal origin and co-existence with substance P
45. Calcitonin gene-related peptide (CGRP): Perivascular distribution and vasodilatory effects
46. Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery