Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 21, 2010, Pages 7580-7585

  Song, Hyunmin ^a   Oh, Sei Ryang ^b   Lee, Hyeong Kyu ^b   Han, Gyoonhee ^c   Kim, Joo Heon ^d   Chang, Hyeun Wook ^e   Doh, Kyung Eun ^a   Rhee, Hee Kyung ^f   Choo, Hea Young Park ^a  

^a Ewha Womans University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Yonsei University   (South Korea)

^d Chungnam National University   (South Korea)

^e Yeungnam University   (South Korea)

^f Sookmyung Women's University   (South Korea)

Author keywords

5 LOX inhibitors; Airway hypersensitiveness; Benzoxazoles

Indexed keywords

5 CHLORO N (4 ETHYLPHENYL)BENZO[D]OXAZOL 2 AMINE; BENZOXAZOLE DERIVATIVE; LEUKOTRIENE C4; LEUKOTRIENE DERIVATIVE; LIPOXYGENASE INHIBITOR; MONTELUKAST; N (4 ETHYLPHENYL) 5 METHYLBENZO[D]OXAZOL 2 AMINE; UNCLASSIFIED DRUG; ZILEUTON;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN;

ALLERGENS; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ASTHMA; BENZOXAZOLES; LIPOXYGENASE INHIBITORS; MICE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957987009     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.047     Document Type: Article

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