메뉴 건너뛰기




Volumn 6, Issue 9, 2010, Pages 1485-1496

Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation

Author keywords

cell cycle; chemoradiation; chemotherapy; radiosensitization; radiotherapy

Indexed keywords

7 METHYLTHIOMETHYLPACLITAXEL; ANTINEOPLASTIC AGENT; BLEOMYCIN; CETUXIMAB; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE; CYCLINE; DOCETAXEL; DOXORUBICIN; ERLOTINIB; ETOPOSIDE; FLOXURIDINE; FLUDARABINE; FLUOROPYRIMIDINE; FLUOROURACIL; GEFITINIB; GEMCITABINE; HYDROXYUREA; IRINOTECAN; NAVELBINE; PACLITAXEL; PANITUMUMAB; PEMETREXED; TOPOTECAN; VINFLUNINE;

EID: 77957965367     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.10.104     Document Type: Review
Times cited : (26)

References (58)
  • 1
    • 77957933730 scopus 로고    scopus 로고
    • Combined radiotherapy and chemotherapy
    • 4th Edition. Van der Kogel A, Joiner M Eds. Hodder Arnold, UK
    • Gregoire V, Baumann M: Combined radiotherapy and chemotherapy. In: Basic Clinical Radiobiology (4th Edition). Van der Kogel A, Joiner M (Eds). Hodder Arnold, UK, 246-258 (2009).
    • (2009) Basic Clinical Radiobiology , pp. 246-258
    • Gregoire, V.1    Baumann, M.2
  • 2
    • 0018425119 scopus 로고
    • Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
    • Steel GG, Peckham MJ: Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int. J. Radiat. Oncol. Biol. Phys. 5(1), 85-91 (1979).
    • (1979) Int. J. Radiat. Oncol. Biol. Phys. , vol.5 , Issue.1 , pp. 85-91
    • Steel, G.G.1    Peckham, M.J.2
  • 3
    • 84960423528 scopus 로고    scopus 로고
    • Irradiation-induced damage and the DNA damage response
    • 4th Edition Van der Kogel A Joiner M Eds Hodder Arnold UK
    • Wouters BG, Begg A: Irradiation-induced damage and the DNA damage response. In: Basic Clinical Radiobiology (4th Edition). Van der Kogel A, Joiner M (Eds). Hodder Arnold, UK, 11-26 (2009)
    • (2009) Basic Clinical Radiobiology , pp. 11-26
    • Wouters, B.G.1    Begg, A.2
  • 4
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan MB, Bartek J: Cell-cycle checkpoints and cancer. Nature 432(7015), 316-323 (2004).
    • (2004) Nature , vol.432 , Issue.7015 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 5
    • 0029049577 scopus 로고
    • Cellular targets for activation by the E2F1 transcription factor include DNA synthesis-and G1/S-regulatory genes
    • DeGregori J, Kowalik T, Nevins JR: Cellular targets for activation by the E2F1 transcription factor include DNA synthesis-and G1/S-regulatory genes. Mol.Cell Biol. 15(8), 4215-4224 (1995).
    • (1995) Mol.Cell Biol. , vol.15 , Issue.8 , pp. 4215-4224
    • DeGregori, J.1    Kowalik, T.2    Nevins, J.R.3
  • 6
    • 0034616913 scopus 로고    scopus 로고
    • Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage
    • Agami R, Bernards R: Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell 102(1), 55-66 (2000).
    • (2000) Cell. , vol.102 , Issue.1 , pp. 55-66
    • Agami, R.1    Bernards, R.2
  • 9
    • 85136369842 scopus 로고    scopus 로고
    • Tumour growth and response to radiation
    • 4th Edition Van der Kogel A Joiner M Eds Hodder Arnold London
    • Zips D: Tumour growth and response to radiation. In: Basic Clinical Radiobiology (4th Edition). Van der Kogel A, Joiner M (Eds). Hodder Arnold, London, 78-101 (2009)
    • (2009) Basic Clinical Radiobiology , pp. 78-101
    • Zips, D.1
  • 10
    • 0037304502 scopus 로고    scopus 로고
    • Chemoradiotherapy: Emerging treatment improvement strategies
    • Milas L, Mason KA, Liao Z, Ang KK: Chemoradiotherapy: emerging treatment improvement strategies. Head Neck. 25(2), 152-167 (2003).
    • (2003) Head Neck. , vol.25 , Issue.2 , pp. 152-167
    • Milas, L.1    Mason, K.A.2    Liao, Z.3    Ang, K.K.4
  • 11
    • 0034887884 scopus 로고    scopus 로고
    • Cell cycle-mediated drug resistance: An emerging concept in cancer therapy
    • Shah MA, Schwartz GK: Cell cycle-mediated drug resistance: an emerging concept in cancer therapy. Clin. Cancer Res. 7(8), 2168-2181 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.8 , pp. 2168-2181
    • Shah, M.A.1    Schwartz, G.K.2
  • 12
    • 0002309215 scopus 로고
    • Variation in several responses of hela cells to X-irradiation during the division cycle
    • Terasima T, Tolmach LJ: Variation in several responses of HeLa cells to X-irradiation during the division cycle. Biophys. J. 3, 11-33 (1963).
    • (1963) Biophys. J. , vol.3 , pp. 11-33
    • Terasima, T.1    Tolmach, L.J.2
  • 15
    • 34748903527 scopus 로고    scopus 로고
    • Antimetabolite radiosensitizers
    • Shewach DS, Lawrence TS: Antimetabolite radiosensitizers. J. Clin. Oncol. 25(26), 4043-4050 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.26 , pp. 4043-4050
    • Shewach, D.S.1    Lawrence, T.S.2
  • 16
    • 0033970910 scopus 로고    scopus 로고
    • Radiosensitivity of thymidylate synthase-deficient human tumor cells is affected by progression through the G1 restriction point into S-phase: Implications for fluoropyrimidine radiosensitization
    • Hwang HS, Davis TW, Houghton JA, Kinsella TJ: Radiosensitivity of thymidylate synthase-deficient human tumor cells is affected by progression through the G1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization. Cancer Res. 60(1), 92-100 (2000).
    • (2000) Cancer Res. , vol.60 , Issue.1 , pp. 92-100
    • Hwang, H.S.1    Davis, T.W.2    Houghton, J.A.3    Kinsella, T.J.4
  • 17
    • 0031010452 scopus 로고    scopus 로고
    • The interaction of hydroxyurea and ionizing radiation in human cervical carcinoma cells
    • Kuo ML, Kunugi KA, Lindstrom MJ, Kinsella TJ: The interaction of hydroxyurea and ionizing radiation in human cervical carcinoma cells. Cancer J. Sci. Am. 3(3), 163-173 (1997).
    • (1997) Cancer J. Sci. Am. , vol.3 , Issue.3 , pp. 163-173
    • Kuo, M.L.1    Kunugi, K.A.2    Lindstrom, M.J.3    Kinsella, T.J.4
  • 18
    • 12844287650 scopus 로고    scopus 로고
    • Combined modality therapy of gemcitabine and radiation
    • Pauwels B, Korst A, Lardon F, Vermorken J: Combined modality therapy of gemcitabine and radiation. Oncologist 10(1), 34-51 (2005).
    • (2005) Oncologist , vol.10 , Issue.1 , pp. 34-51
    • Pauwels, B.1    Korst, A.2    Lardon, F.3    Vermorken, J.4
  • 19
    • 0142217877 scopus 로고    scopus 로고
    • Cell cycle effect of gemcitabine and its role in the radiosensitizing mechanism in vitro
    • Pauwels B, Korst AEC, Pattyn GGO et al.: Cell cycle effect of gemcitabine and its role in the radiosensitizing mechanism in vitro. Int. J. Radiat. Oncol. Biol. Phys. 57(4), 1075-1083 (2003).
    • (2003) Int. J. Radiat. Oncol. Biol. Phys. , vol.57 , Issue.4 , pp. 1075-1083
    • Pauwels, B.1    Korst, A.E.C.2    Pattyn, G.G.O.3
  • 20
    • 58149252481 scopus 로고    scopus 로고
    • Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: A review
    • Morgan MA, Parsels LA, Maybaum J, Lawrence TS: Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: a review. Clin. Cancer Res. 14(21), 6744-6750 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.21 , pp. 6744-6750
    • Morgan, M.A.1    Parsels, L.A.2    Maybaum, J.3    Lawrence, T.S.4
  • 21
    • 0028032726 scopus 로고
    • The role of fludarabine-induced apoptosis and cell cycle synchronization in enhanced murine tumor radiation response in vivo
    • Gregoire V, Van NT, Stephens LC et al.: The role of fludarabine-induced apoptosis and cell cycle synchronization in enhanced murine tumor radiation response in vivo. Cancer Res. 54(23), 6201-6209 (1994).
    • (1994) Cancer Res. , vol.54 , Issue.23 , pp. 6201-6209
    • Gregoire, V.1    Van, N.T.2    Stephens, L.C.3
  • 22
    • 0032031453 scopus 로고    scopus 로고
    • Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid
    • DOI 10.1016/S0006-2952(97)00505-4, PII S0006295297005054
    • Kruczynski A, Barret JM, Etievant C et al.: Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid. Biochem. Pharmacol. 55(5), 635-648 (1998). (Pubitemid 28077822)
    • (1998) Biochemical Pharmacology , vol.55 , Issue.5 , pp. 635-648
    • Kruczynski, A.1    Barret, J.-M.2    Etievant, C.3    Colpaert, F.4    Fahy, J.5    Hill, B.T.6
  • 23
    • 0031912695 scopus 로고    scopus 로고
    • Preclinical in vivo antitumor activity of vinflunine a novel fluorinated Vinca alkaloid
    • Kruczynski A, Colpaert F, Tarayre JP et al.: Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid. Cancer Chemother. Pharmacol. 41(6), 437-447 (1998).
    • (1998) Cancer Chemother. Pharmacol. , vol.41 , Issue.6 , pp. 437-447
    • Kruczynski, A.1    Colpaert, F.2    Tarayre, J.P.3
  • 24
    • 0029986999 scopus 로고    scopus 로고
    • Potentiation of radiation therapy by vinorelbine navelbine in non-small cell lung cancer
    • Edelstein MP, Wolfe LA 3rd, Duch DS: Potentiation of radiation therapy by vinorelbine (Navelbine) in non-small cell lung cancer. Semin. Oncol. 23(2 Suppl. 5), 41-47 (1996)
    • (1996) Semin. Oncol. , vol.23 , Issue.2-5 , pp. 41-47
    • Edelstein, M.P.1    Wolfe III, L.A.2    Duch, D.S.3
  • 25
    • 0034764116 scopus 로고    scopus 로고
    • Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells
    • Fukuoka K, Arioka H, Iwamoto Y et al.: Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells. Lung Cancer 34(3), 451-460 (2001).
    • (2001) Lung Cancer , vol.34 , Issue.3 , pp. 451-460
    • Fukuoka, K.1    Arioka, H.2    Iwamoto, Y.3
  • 26
    • 42449114880 scopus 로고    scopus 로고
    • Comparative study of the radiosensitizing and cell cycle effects of vinflunine and vinorelbine in vitro
    • Simoens C, Lardon F, Pauwels B et al.: Comparative study of the radiosensitizing and cell cycle effects of vinflunine and vinorelbine, in vitro. BMC Cancer 8, 65-77 (2008).
    • (2008) BMC Cancer , vol.8 , pp. 65-77
    • Simoens, C.1    Lardon, F.2    Pauwels, B.3
  • 27
    • 33646473687 scopus 로고    scopus 로고
    • Cell cycle effects of vinflunine the most recent promising Vinca alkaloid and its interaction with radiation in vitro
    • Simoens C, Vermorken JB, Korst AE et al.: Cell cycle effects of vinflunine, the most recent promising Vinca alkaloid, and its interaction with radiation, in vitro. Cancer Chemother. Pharmacol. 58(2), 210-218 (2006).
    • (2006) Cancer Chemother. Pharmacol. , vol.58 , Issue.2 , pp. 210-218
    • Simoens, C.1    Vermorken, J.B.2    Korst, A.E.3
  • 28
    • 0036238899 scopus 로고    scopus 로고
    • Mechanism of vinorelbine-induced radiosensitization of human small cell lung cancer cells
    • Fukuoka K, Arioka H, Iwamoto Y et al.: Mechanism of vinorelbine-induced radiosensitization of human small cell lung cancer cells. Cancer Chemother. Pharmacol. 49(5), 385-390 (2002).
    • (2002) Cancer Chemother. Pharmacol. , vol.49 , Issue.5 , pp. 385-390
    • Fukuoka, K.1    Arioka, H.2    Iwamoto, Y.3
  • 29
    • 0027967689 scopus 로고
    • The in vivo interaction between vincristine and radiation in a C3H mammary carcinoma and the feet of CDF1 mice
    • Grau C, Hoyer M, Overgaard J: The in vivo interaction between vincristine and radiation in a C3H mammary carcinoma and the feet of CDF1 mice. Int. J. Radiat. Oncol. Biol. Phys. 30(5), 1141-1146 (1994).
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.30 , Issue.5 , pp. 1141-1146
    • Grau, C.1    Hoyer, M.2    Overgaard, J.3
  • 30
    • 0032900181 scopus 로고    scopus 로고
    • Combination of taxanes with radiation: Preclinical studies
    • Milas L, Milas MM, Mason KA: Combination of taxanes with radiation: preclinical studies. Semin Radiat Oncol. 9(2 Suppl. 1), 12-26 (1999).
    • (1999) Semin Radiat Oncol. , vol.9 , Issue.2 SUPPL. 1 , pp. 12-26
    • Milas, L.1    Milas, M.M.2    Mason, K.A.3
  • 31
    • 0028999349 scopus 로고
    • S-phase specificity of cell killing by docetaxel taxotere in synchronised hela cells
    • Hennequin C, Giocanti N, Favaudon V: S-phase specificity of cell killing by docetaxel (Taxotere) in synchronised HeLa cells. Br. J. Cancer 71(6), 1194-1198 (1995).
    • (1995) Br. J. Cancer , vol.71 , Issue.6 , pp. 1194-1198
    • Hennequin, C.1    Giocanti, N.2    Favaudon, V.3
  • 32
    • 0030000299 scopus 로고    scopus 로고
    • Interaction of ionizing radiation with paclitaxel taxol and docetaxel taxotere in hela and SQ20B cells
    • Hennequin C, Giocanti N, Favaudon V: Interaction of ionizing radiation with paclitaxel (Taxol) and docetaxel (Taxotere) in HeLa and SQ20B cells. Cancer Res. 56(8), 1842-1850 (1996).
    • (1996) Cancer Res. , vol.56 , Issue.8 , pp. 1842-1850
    • Hennequin, C.1    Giocanti, N.2    Favaudon, V.3
  • 33
    • 0035479085 scopus 로고    scopus 로고
    • The novel taxane analogs BMS-184476 and BMS-188797 potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells
    • Kim JS, Amorino GP, Pyo H et al.: The novel taxane analogs, BMS-184476 and BMS- 188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells. Int. J. Radiat. Oncol. Biol. Phys. 51(2), 525-534 (2001).
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.51 , Issue.2 , pp. 525-534
    • Kim, J.S.1    Amorino, G.P.2    Pyo, H.3
  • 34
    • 0025785082 scopus 로고
    • Antitumor activity of a camptothecin derivative CPT-11 against human tumor xenografts in nude mice
    • Kawato Y, Furuta T, Aonuma M et al.: Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice. Cancer Chemother. Pharmacol. 28(3), 192-198 (1991).
    • (1991) Cancer Chemother. Pharmacol. , vol.28 , Issue.3 , pp. 192-198
    • Kawato, Y.1    Furuta, T.2    Aonuma, M.3
  • 35
    • 68749104545 scopus 로고    scopus 로고
    • Camptothecin radiation sensitization
    • Choy H Ed. Humana Press NJ USA
    • Rich TA: Camptothecin radiation sensitization. In: Chemoradiation in Cancer Therapy (Volume ). Choy H (Ed.). Humana Press, NJ, USA, 93-105 (2003)
    • (2003) Chemoradiation in Cancer Therapy , pp. 93-105
    • Rich, T.A.1
  • 36
    • 0026441127 scopus 로고
    • Posttreatment exposure to camptothecin enhances the lethal effects of x-rays on zaradioresistant human malignant melanoma cells
    • Boothman DA, Wang M, Schea RA et al.: Posttreatment exposure to camptothecin enhances the lethal effects of x-rays on radioresistant human malignant melanoma cells. Int. J. Radiat. Oncol. Biol. Phys. 24(5), 939-948 (1992).
    • (1992) Int. J. Radiat. Oncol. Biol. Phys. , vol.24 , Issue.5 , pp. 939-948
    • Boothman, D.A.1    Wang, M.2    Schea, R.A.3
  • 37
    • 0030907319 scopus 로고    scopus 로고
    • Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives
    • Chen AY, Okunieff P, Pommier Y, Mitchell JB: Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives. Cancer Res. 57(8), 1529-1536 (1997).
    • (1997) Cancer Res. , vol.57 , Issue.8 , pp. 1529-1536
    • Chen, A.Y.1    Okunieff, P.2    Pommier, Y.3    Mitchell, J.B.4
  • 38
    • 0027236181 scopus 로고
    • The interaction of etoposide with radiation: Variation in cytotoxicity with the sequence of treatment
    • Minehan KJ, Bonner JA: The interaction of etoposide with radiation: variation in cytotoxicity with the sequence of treatment. Life Sci. 53(15), L237-L242 (1993).
    • (1993) Life Sci. , vol.53 , Issue.15
    • Minehan, K.J.1    Bonner, J.A.2
  • 39
    • 0027205102 scopus 로고
    • DNA repair and cell cycle interactions in radiation sensitization by the topoisomerase II poison etoposide
    • Giocanti N, Hennequin C, Balosso J, Mahler M, Favaudon V: DNA repair and cell cycle interactions in radiation sensitization by the topoisomerase II poison etoposide. Cancer Res. 53(9), 2105-2111 (1993).
    • (1993) Cancer Res. , vol.53 , Issue.9 , pp. 2105-2111
    • Giocanti, N.1    Hennequin, C.2    Balosso, J.3    Mahler, M.4    Favaudon, V.5
  • 40
    • 0035060810 scopus 로고    scopus 로고
    • Effect of combined treatment with radiation and low dose etoposide on cell survival
    • Shigematsu N, Kawata T, Ihara N et al.: Effect of combined treatment with radiation and low dose etoposide on cell survival. Anticancer Res. 21(1A), 325-328 (2001).
    • (2001) Anticancer Res. , vol.21 , Issue.1 A , pp. 325-328
    • Shigematsu, N.1    Kawata, T.2    Ihara, N.3
  • 41
    • 0025099314 scopus 로고
    • Doxorubicin decreases the repair of radiation-induced DNA damage
    • Bonner JA, Lawrence TS: Doxorubicin decreases the repair of radiation-induced DNA damage. Int. J. Radiat. Biol. 57(1), 55-64 (1990).
    • (1990) Int. J. Radiat. Biol. , vol.57 , Issue.1 , pp. 55-64
    • Bonner, J.A.1    Lawrence, T.S.2
  • 42
    • 0017358070 scopus 로고
    • Molecular interactions between adriamycin and x-ray damage in mammalian tumor cells
    • Byfield JE, Lee YC, Tu L: Molecular interactions between adriamycin and x-ray damage in mammalian tumor cells. Int. J. Cancer 19(2), 186-193 (1977).
    • (1977) Int. J. Cancer , vol.19 , Issue.2 , pp. 186-193
    • Byfield, J.E.1    Lee, Y.C.2    Tu, L.3
  • 43
    • 0017195827 scopus 로고
    • The effect of adriamycin and radiation on G2 progression
    • 9 Pt 1
    • Kimler BF, Leeper DB: The effect of adriamycin and radiation on G2 progression. Cancer Res. 36(9 Pt 1), 3212-3216 (1976).
    • (1976) Cancer Res. , vol.36 , pp. 3212-3216
    • Kimler, B.F.1    Leeper, D.B.2
  • 44
    • 26444577554 scopus 로고    scopus 로고
    • Mechanisms of cell sensitization to a radioimmunotherapy by doxorubicin or paclitaxel in multiple myeloma cell lines
    • 19 Pt 2
    • Supiot S, Gouard S, Charrier J et al.: Mechanisms of cell sensitization to a radioimmunotherapy by doxorubicin or paclitaxel in multiple myeloma cell lines. Clin. Cancer Res. 11(19 Pt 2), S7047-S7052 (2005).
    • (2005) Clin. Cancer Res. , vol.11
    • Supiot, S.1    Gouard, S.2    Charrier, J.3
  • 45
    • 84907110762 scopus 로고
    • Irradiation combined with bleomycin treatment of synchronized cells in culture under oxic and hypoxic conditions
    • Midander J, Littbrand B, Edsmyr F: Irradiation combined with bleomycin treatment of synchronized cells in culture under oxic and hypoxic conditions. Acta Radiol. Oncol. 19(5), 395-400 (1980).
    • (1980) Acta Radiol. Oncol. , vol.19 , Issue.5 , pp. 395-400
    • Midander, J.1    Littbrand, B.2    Edsmyr, F.3
  • 46
    • 0016253857 scopus 로고
    • The effect of bleomycin and radiation in combination on bacteria and mammalian cells in culture
    • Bleehen NM, Gillies NE, Twentyman PR: The effect of bleomycin and radiation in combination on bacteria and mammalian cells in culture. Br. J. Radiol. 47(558), 346-351 (1974).
    • (1974) Br. J. Radiol. , vol.47 , Issue.558 , pp. 346-351
    • Bleehen, N.M.1    Gillies, N.E.2    Twentyman, P.R.3
  • 47
    • 0022922453 scopus 로고
    • The combined effect of bleomycin and irradiation on mouse lip mucosa. 2. Influence on the accumulation and repair of sublethal damage during fractionated irradiation
    • Vanuytsel L, Feng Y, Landuyt W, Leer JW, van der Schueren E: The combined effect of bleomycin and irradiation on mouse lip mucosa. 2. Influence on the accumulation and repair of sublethal damage during fractionated irradiation. Radiother. Oncol. 6(4), 267-273 (1986). (Pubitemid 16026732)
    • (1986) Radiotherapy and Oncology , vol.6 , Issue.4 , pp. 267-273
    • Vanuytsel, L.1    Feng, Y.2    Landuyt, W.3
  • 48
    • 34250345258 scopus 로고    scopus 로고
    • EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms
    • Baumann M, Krause M, Dikomey E et al.: EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms. Radiother. Oncol. 83(3), 238-248 (2007).
    • (2007) Radiother. Oncol. , vol.83 , Issue.3 , pp. 238-248
    • Baumann, M.1    Krause, M.2    Dikomey, E.3
  • 49
    • 22344449812 scopus 로고    scopus 로고
    • Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells
    • Giovannetti E, Mey V, Nannizzi S et al.: Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Mol. Pharmacol. 68(1), 110-118 (2005).
    • (2005) Mol. Pharmacol. , vol.68 , Issue.1 , pp. 110-118
    • Giovannetti, E.1    Mey, V.2    Nannizzi, S.3
  • 52
    • 0037342884 scopus 로고    scopus 로고
    • Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: A therapeutic approach on the basis of preclinical research of human cancer cell lines
    • Chen YC, Pandya K, Keng PC et al.: Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines. Clin. Cancer Res. 9(3), 969-975 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.3 , pp. 969-975
    • Chen, Y.C.1    Pandya, K.2    Keng, P.C.3
  • 53
    • 4444344407 scopus 로고    scopus 로고
    • G2 checkpoint abrogators as anticancer drugs
    • Kawabe T: G2 checkpoint abrogators as anticancer drugs. Mol. Cancer Ther. 3(4), 513-519 (2004).
    • (2004) Mol. Cancer Ther. , vol.3 , Issue.4 , pp. 513-519
    • Kawabe, T.1
  • 54
    • 0037241328 scopus 로고    scopus 로고
    • Potentiation of DNA-damage-induced cytotoxicity by G2 checkpoint abrogators
    • Tenzer A, Pruschy M: Potentiation of DNA-damage-induced cytotoxicity by G2 checkpoint abrogators. Curr. Med. Chem. Anticancer Agents 3(1), 35-46 (2003).
    • (2003) Curr. Med. Chem. Anticancer Agents , vol.3 , Issue.1 , pp. 35-46
    • Tenzer, A.1    Pruschy, M.2
  • 55
    • 0028936626 scopus 로고
    • Differential sensitivity of p53-and p53+ cells to caffeine-induced radiosensitization and override of G2 delay
    • Powell SN, DeFrank JS, Connell P et al.: Differential sensitivity of p53- and p53+ cells to caffeine-induced radiosensitization and override of G2 delay. Cancer Res. 55(8), 1643-1648 (1995).
    • (1995) Cancer Res. , vol.55 , Issue.8 , pp. 1643-1648
    • Powell, S.N.1    DeFrank, J.S.2    Connell, P.3
  • 56
    • 0030802463 scopus 로고    scopus 로고
    • Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function
    • Bracey TS, Williams AC, Paraskeva C: Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function. Clin. Cancer Res. 3(8), 1371-1381 (1997).
    • (1997) Clin. Cancer Res. , vol.3 , Issue.8 , pp. 1371-1381
    • Bracey, T.S.1    Williams, A.C.2    Paraskeva, C.3
  • 57
    • 0029992520 scopus 로고    scopus 로고
    • Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine UCN-01 a new G2-checkpoint inhibitor
    • Bunch RT, Eastman A: Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor. Clin. Cancer Res. 2(5), 791-797 (1996).
    • (1996) Clin. Cancer Res. , vol.2 , Issue.5 , pp. 791-797
    • Bunch, R.T.1    Eastman, A.2
  • 58
    • 0037194414 scopus 로고    scopus 로고
    • Abrogation of the radiationinduced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines
    • Playle LC, Hicks DJ, Qualtrough D, Paraskeva C: Abrogation of the radiationinduced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines. Br. J. Cancer 87(3), 352-358 (2002).
    • (2002) Br. J. Cancer , vol.87 , Issue.3 , pp. 352-358
    • Playle, L.C.1    Hicks, D.J.2    Qualtrough, D.3    Paraskeva, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.