Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-β-deficient neutrophils in a congenital neutropenia syndrome

Blood

Volumn 116, Issue 15, 2010, Pages 2783-2792

  Jun, Hyun Sik ^a   Lee, Young Mok ^a   Cheung, Yuk Yin ^a   McDermott, David H ^b   Murphy, Philip M ^b   De Ravin, Suk See ^b   Mansfield, Brian C ^a   Chou, Janice Y ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATASE BETA; GLUCOSE TRANSPORTER 1; GRANULOCYTE COLONY STIMULATING FACTOR; LACTIC ACID; LIPOCORTIN 5; PROTEIN P47; PROTEIN SUBUNIT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG; CASPASE 3; G6PC3 PROTEIN, HUMAN; GLUCOSE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CONGENITAL NEUTROPENIA SYNDROME; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENERGY; ENZYME ACTIVITY; ENZYME DEFICIENCY; GLUCOSE METABOLISM; GLUCOSE RECYCLING; GLUCOSE TRANSPORT; GLYCOLYSIS; HEXOSE MONOPHOSPHATE SHUNT; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MOUSE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RESPIRATORY BURST; ADOLESCENT; ANIMAL; APOPTOSIS; C57BL MOUSE; CHILD; FEMALE; GENETICS; GLYCOGEN STORAGE DISEASE TYPE 1; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS; SYNDROME;

ADENOSINE TRIPHOSPHATE; ADOLESCENT; ANIMALS; ANNEXIN A5; APOPTOSIS; CASPASE 3; CHILD; CYTOPLASM; ENDOPLASMIC RETICULUM; FEMALE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE-6-PHOSPHATASE; GLYCOGEN STORAGE DISEASE TYPE I; HUMANS; LACTIC ACID; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NADPH OXIDASE; NEUTROPENIA; NEUTROPHILS; STRESS, PHYSIOLOGICAL; SYNDROME;

EID: 77957959873     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-12-258491     Document Type: Article

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