Phenoxazine derivatives suppress the infections caused by herpes simplex virus type-1 and herpes simplex virus type-2 intravaginally inoculated into mice

Journal of Pharmacological Sciences

Volumn 114, Issue 1, 2010, Pages 85-91

  Hayashi, Kyoko ^a   Hayashi, Toshimitsu ^a   Miyazawa, Keisuke ^b   Tomoda, Akio ^b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Herpes simplex virus type 2; Herpes simplex virus type l; Intravaginal application; Phenoxazine

Indexed keywords

2 AMINO 4,4ALPHA DIHYDRO 4ALPHA 7 DIMETHYL 3H PHENOXAZINE 3 ONE; 2 AMINOPHENOXAZINE 3 ONE; 3 AMINO 1,4ALPHA DIHYDRO 4ALPHA 8 DIMETHYL 2H PHENOXAZINE 2 ONE; ACICLOVIR; PHENOXAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG SYNTHESIS; EVENING DOSAGE; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; IN VIVO STUDY; INOCULATION; MORNING DOSAGE; MOUSE; NONHUMAN; SURVIVAL RATE; VIRUS REPLICATION; VIRUS STRAIN;

EID: 77957954269     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10027FP     Document Type: Article

References (25)

1. Fiddian P, Yeo JM, Clark AE. Treatment of herpes labialis. J Infect. 1983;6:41-47.
2. Linehan MM, Richman S, Krummenacher C, Eisenberg RJ, Cohen GH, Iwasaki A. In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa. J Virol. 2004;78:2530-2536.
3. Whitley RJ, Hillard JK. Cercopithecine herpesvirus (B virus). In: Knipe PM, Howle PM, editors. Fields Virology. 4th ed. Philadelphia: Lippincott Williams and Wilkins; 2001. p. 2835-2848.
4. Celum CL. The interaction between herpes simplex virus and human immunodeficiency virus. Herpes. 2004;11:36A-45A.
5. Wald A, Kink K. Risk of human immunodeficienty virus infection in herpes simplex virus type-2 seropositive persons: a metaanalysis. J Infect Dis. 2002;185:45-52.
6. Schmit I, Boivin G. Characterization of the DNA polymerase and thymidine kinase genes of herpes simplex virus isolates form AIDS patients in whom acyclovir and foscarnt therapy sequentially failed. J Infect Dis. 1999;180:487-490.
7. Palliser D, Chowdhury D, Wang Q-Y, Lee SJ, Bronson RT, Knipe DM, et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature. 2006;439:89-94.
8. Wu Y, Navarro F, Lal A, Basar E, Pandey RK, Manoharan M, et al. Durable protection from herpes simplex virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe. 2009;5:84-94.
9. Iwata A, Yamaguchi T, Sato K, Izumi R, Tomoda A. Antiviral activity of 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine- 3-one on poliovirus. Tohoku J Exp Med. 2003;200:161-165.
10. Iwata A, Yamaguchi T, Sato K, Yoshitake N, Tomoda A. Suppression of proliferation of poliovirus and porcine parvovirus by novel phenoxazines, 2-amino-4,4α-dihydro-4α-7-dimethyl-3Hphenoxazine- 3-one and 3-amino-1,4α-dihydro-4α-8-dimethyl- 2H-phenoxazine-2-one. Biol Pharm Bull. 2005;28:905-907.
11. Hayashi K, Hayashi T, Tomoda A. Phenoxazine derivatives inactivate human cytomegalovirus, herpes simplex virus-1, and herpes simplex virus-2 in vitro. J Pharmacol Sci. 2008;106:369-375.
12. Tomoda A, Arai S, Ishida R. An improved method for the rapid preparation of 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-pheno xazine- 3-one, a novel antitumor agent. Bioorg Med Chem Lett. 2001;11:1057-1058.
13. Shimizu S, Suzuki M, Tomoda A, Arai S, Taguchi H, Hanawa T, et al. Phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tuberculosis mycobacteria. Tohoku J Exp Med. 2004;203:47-52.
14. Kaushic C, Ashkar AA, Reid LA, Rosenthal KL. Progesterone increases susceptibility and decrease immune responses to genital herpes infection. J Virol. 2003;77:4558-4565.
15. Kohno K, Miyake M, Sano O, Tanaka-Kataoka M, Yamamoto S, Koya-Miyata S, et al. Anti-inflammatory and immunomodulatory properties of 2-amino-3H-phenoxazin-3-one. Biol Pharm Bull. 2008;31:1938-1945.
16. Hendrich AB, Stanczak K, Momorowska M, Motohash N, Kawase M, Michalak K. A study on the perturbation of model lipid membranes by phenoxazines. Bioorg Med Chem. 2006;14:5948-5954.
17. Akazawa M, Koshibu-Koizumi J, Iwamoto T, Takasaki M, Nakamura M, Tomoda A. Effects of novel phenoxazine compounds, 2-amino-4,4α-dihydro-4α, 7-dimethyl-3H-phenoxazine- 3-one and 3-amino-1,4α-dihydro-4α,8-dimethyl-2H-phenoxazine- 2-one on phytohemagglutinin- or anti-human IgM activated proliferation of mononuclear cells in human peripheral blood. Tohoku J Exp Med. 2002;196:185-192.
18. Gao S, Takano T, Sada K, He J, Noda C, Hori-Tamura N, et al. A novel phenoxazine derivative suppresses surface IgM expression in DT40 B cell line. Br J Pharmacol. 2002;137:749-755.
19. Enoki E, Sada K, Qu X, Kyo S, Shahjahan Miah SM, Hatani T, et al. The phenoxazine derivative Phx-1 suppresses IgE-mediated degranulation in rat basophilic leukemia RNL-2H3 cells. J Pharmacol Sci. 2004;94:329-333.
20. Mori H, Honda K, Ishida R, Nohira T, Tomoda A. Antutumor activity of 2-amino-4,4α-dihydro-4α, 7-dimethyl-3H-phenoxazine- 3-one against Meth A tumor transplanted into BALB/c mice. Anticancer Drugs. 2000;11:653-657.
21. Shimamoto T, Tomoda A, Ishida R, Ohyashiki K. Antitumor effects of a novel phenoxazine derivative on human leukemia cell lines in vitro and in vivo. Clin Cancer Res. 2001;7:704-708.
22. Miyano-Kurosaki N, Kurosaki K, Takaku H, Hayafune M, Shirato K, Kasuga T, et al. 2-Aminophenoxazine-3-one suppresses the growth of mouse malignant melanoma B16 cells transplanted into C57BL/6Cr Slc mice. Biol Pharm Bull. 2006;29:2197-2201.
23. Elion G. Mechanism of action of antiviral selectivity of acyclovir. Am J Med. 1982;73:7-13.
24. Uruma T, Yamaguchi H, Fukuda M, Kawakami H, Goto H, Kishimoto T, et al. Chlamydia pneumoniae growth inhibition in human monocytic THP-1 cells and human epithelial HEp-2 cells by a novel phenoxazine derivative. J Med Microbiol. 2005;54:1143-1149.
25. Hanawa T, Osaki T, Manzoku T, Fukuda M, Kawakami H, Tomoda A, et al. In vitro antibacterial activity of Phx-3 against Helicobacter pylori. Biol Pharm Bull. 2010;32:188-191.