A previously unreported function of Β1 B integrin isoform in caspase-8-dependent integrin-mediated keratinocyte death

Journal of Investigative Dermatology

Volumn 130, Issue 11, 2010, Pages 2569-2577

  Lotti, Roberta ^a   Marconi, Alessandra ^a   Truzzi, Francesca ^a   Dallaglio, Katiuscia ^a   Gemelli, Claudia ^a   Borroni, Riccardo G ^a   Palazzo, Elisabetta ^a   Pincelli, Carlo ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; BETA1 INTEGRIN NEUTRALIZING ANTIBODY; BETA1A INTEGRIN; BETA1B INTEGRIN; CASPASE 8; FAS ANTIGEN; FAS LIGAND; GLYCOPROTEIN; INTEGRIN; NEUTRALIZING ANTIBODY; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANOIKIS; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL FUNCTION; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOPLASM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KERATINOCYTE; MEDIATOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SUSPENSION CELL CULTURE; WILD TYPE;

EID: 77957935569     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.195     Document Type: Article

References (32)

1. Altruda F, Cervella P, Tarone G et al. (1990) A human integrin beta 1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing. Gene 95:261-6
2. Aoudjit F, Vuori K (2001) Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J Cell Biol 152:633-43
3. Arredondo J, Chernyavsky AI, Karaouni A et al. (2005) Novel mechanisms of target cell death and survival and of therapeutic action of IVIg in Pemphigus. Am J Pathol 167:1531-44
4. Balzac F, Belkin AM, Koteliansky VE et al. (1993) Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit. J Cell Biol 121:171-8
5. Boukamp P, Petrussevska RT, Breitkreutz D et al. (1988) Normal keratiniza-tion in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106:761-71
6. Brassard DL, Maxwell E, Malkowski M et al. (1999) Integrin alpha(v)beta(3)-mediated activation of apoptosis. Exp Cell Res 251:33-45
7. Ferreira M, Fujiwara H, Morita K et al. (2009) An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors. Cancer Res 69:1334-42
8. Fleischmajer R, Perlish JS, MacDonald ED et al. (1998) There is binding of collagen IV to beta 1 integrin during early skin basement membrane assembly. Ann NY Acad Sci 857:212-27
9. Frisch SM (1999) Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis. Curr Biol 9:1047-9
10. Frisch SM, Francis H (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124:619-26
11. Giancotti FG, Ruoslahti E (1990) Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 60:849-59
12. Grande A, Piovani B, Aiuti A et al. (1999) Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hemato-poietic stem cells. Blood 93:3276-85
13. Grossmann J, Walther K, Artinger M et al. (2001) Apoptotic signaling during initiation of detachment-induced apoptosis ("anoikis") of primary human intestinal epithelial cells. Cell Growth Differ 12:147-55
14. Howlett AR, Bailey N, Damsky C et al. (1995) Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma. J Cell Sci 108:1945-57
15. Janes SM, Watt FM (2004) Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol 166:419-31
16. Kee WJ, Li ER, Watt FM (2000) beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum. J Cell Biochem 78:97-111
17. Kozlova NI, Morozevich GE, Chubukina AN et al. (2001) Integrin alphavbeta3 promotes anchorage-dependent apoptosis in human intestinal carcinoma cells. Oncogene 20:4710-7
18. Marconi A, Atzei P, Panza C et al. (2004) FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes. J Cell Sci 117:5815-23
19. Menon B, Krishnamurthy P, Kaverina E et al. (2006) Expression of the cytoplasmic domain of beta1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway. Basic Res Cardiol 101:485-93
20. Muzio M, Stockwell BR, Stennicke HR et al. (1998) An induced proximity model for caspase-8 activation. J Biol Chem 273:2926-30
21. Pincelli C, Haake AR, Benassi L et al. (1997) Autocrine nerve growth factor protects human keratinocytes from apoptosis through its high affinity receptor (TRK): a role for BCL-2. J Invest Dermatol 109:757-64
22. Plath T, Detjen K, Welzel M et al. (2000) A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor. J Cell Biol 150:1467-78
23. Rajeswari J, Pande G (2006) Direct association between caspase 3 and alpha5beta1 integrin and its role during anoikis of rat fibroblasts. Cell Biol Int 30:963-9
24. Retta SF, Balzac F, Ferraris P et al. (1998) beta1-integrin cytoplasmic subdomains involved in dominant negative function. Mol Biol Cell 9:715-31
25. Rytömaa M, Martins LM, Downward J (1999) Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis. Curr Biol 9:1043-6
26. Ryu HY, Emberley JK, Schlezinger JJ et al. (2005) Environmental chemical-induced bone marrow B cell apoptosis: death receptor-independent activation of a caspase-3 to caspase-8 pathway. Mol Pharmacol 68:1087-96
27. Savoia P, Cremona O, Trusolino L et al. (1994) Integrins and basement membrane proteins in skin carcinomas. Pathol Res Pract 190:950-4
28. Stupack DG, Puente XS, Boutsaboualoy S et al. (2001) Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 155:459-70
29. Tiberio R, Marconi A, Fila C et al. (2002) Keratinocytes enriched for stem cells are protected from anoikis via an integrin signaling pathway in a Bcl-2 dependent manner. FEBS Lett 524:139-44
30. Truzzi F, Marconi A, Lotti R et al. (2008) Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. J Invest Dermatol 128:2031-40
31. Zhang W, Hanks AN, Boucher K et al. (2005) UVB-induced apoptosis drives clonal expansion during skin tumor development. Carcinogenesis 26:249-57
32. Zhao H, Ross FP, Teitelbaum SL (2005) Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal. Mol Endocrinol 19:771-80