Erythrina variegata extract exerts osteoprotective effects by suppression of the process of bone resorption

British Journal of Nutrition

Volumn 104, Issue 7, 2010, Pages 965-971

  Zhang, Yan ^a   Li, Qi ^b   Li, Xiaoli ^c   Wan, Hoi Ying ^d   Wong, Man Sau ^b,d  

^a UNIVERSITY OF SHANGHAI FOR SCIENCE AND TECHNOLOGY   (China)

^b State Key Laboratory of Chinese Medicine and Molecular Pharmacology   (China)

^c UNIVERSITY OF CHICAGO   (United States)

^d HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Bone resorption; Erythrina variegata L.; Osteoporosis; Ovariectomised rats

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CALCIUM; CATHEPSIN K; ERYTHRINA EXTRACT; ERYTHRINA VARIEGATA EXTRACT; GENISTEIN; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PHOSPHORUS; UNCLASSIFIED DRUG; ACID PHOSPHATASE; BONE DENSITY CONSERVATION AGENT; ISOENZYME; PLANT EXTRACT; TARTRATE-RESISTANT ACID PHOSPHATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE PROTECTION; BONE STRUCTURE; CALCIUM BLOOD LEVEL; CALCIUM URINE LEVEL; CELL DIFFERENTIATION; CELL STRAIN; COCULTURE; CONTROLLED STUDY; CORTICAL BONE; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG TARGETING; ERYTHRINA; ERYTHRINA VARIEGATA; FEMALE; GENE EXPRESSION; LOW DRUG DOSE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; PHOSPHATE BLOOD LEVEL; PHOSPHATE URINE LEVEL; PROPHYLAXIS; QUANTITATIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHAM PROCEDURE; TIBIA; TRABECULAR BONE; UPREGULATION; ANIMAL; DRUG EFFECT; GENETICS; MACROPHAGE; METABOLISM; MOUSE; OSTEOPOROSIS; PHYTOTHERAPY; RAT; SPRAGUE DAWLEY RAT;

ERYTHRINA VARIEGATA; RATTUS;

ACID PHOSPHATASE; ANIMALS; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CALCIUM; CATHEPSIN K; CELL DIFFERENTIATION; ERYTHRINA; FEMALE; GENISTEIN; ISOENZYMES; MACROPHAGES; MICE; OSTEOCLASTS; OSTEOPOROSIS; OSTEOPROTEGERIN; OVARIECTOMY; PHOSPHORUS; PHYTOTHERAPY; PLANT EXTRACTS; RANK LIGAND; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77957921074     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510001789     Document Type: Article

References (24)

1. Cooper C, Westlake S, Harvey N, et al. (2006) Review: Developmental origins of osteoporotic fracture. Osteoporos Int 17, 337-347.
2. Dennison E, Cole Z & Cooper C (2005) Diagnosis and epidemiology of osteoporosis. Curr Opin Rheumatol 17, 456-461.
3. Zhang Y, ChenWF, LaiWP, et al. (2008) Soy isoflavones and their bone protective effects. Inflammopharmacology 16, 213-215.
4. Huot L, Couris CM, Tainturier V, et al. (2008) Trends in HRT and anti-osteoporosis medication prescribing in a European population after the WHI study. Osteoporos Int 19, 1047-1054.
5. Palacios S (2008) Advances in hormone replacement therapy: Making the menopause manageable. BMC Womens Health 8, 22.
6. Hertrampf T, Gruca MJ, Seibel J, et al. (2007) The boneprotective effect of the phytoestrogen genistein is mediated via ER a-dependent mechanisms and strongly enhanced by physical activity. Bone 40, 1529-1535.
7. Szkudelska K & Nogowski L (2007) Genistein-a dietary compound inducing hormonal and metabolic changes. J Steroid Biochem Mol Biol 105, 37-45.
8. Sato M, Tanaka H, Yamaguchi R, et al. (2004) Synergistic effects of mupirocin and an isoflavanone isolated from Erythrina variegata on growth and recovery of methicillin-resistant Staphylococcus aureus. Int J Antimicrob Agents 24, 241-246.
9. Cox PA (1993) Saving the ethnopharmacological heritage of Samoa. J Ethnopharmacol 38, 181-188.
10. Sato M, Tanaka H, Fujiwara S, et al. (2003) Antibacterial property of isoflavonoids isolated from Erythrina variegata against cariogenic oral bacteria. Phytomedicine 10, 427-433.
11. Zhang Y, Li XL, Yao XS, et al. (2008) Osteogenic activities of genistein derivatives were influenced by the presence of prenyl group at ring A. Arch Pharm Res 31, 1534-1539.
12. Li XL, Wang NL, Wong MS, et al. (2006) Four new isoflavonoids from the stem bark of Erythrina variegata. Chem Pharm Bull 54, 570-573.
13. Zhang Y, Li XL, Lai WP, et al. (2007) Anti-osteoporotic effect of Erythrina variegata L. in ovariectomized rats. J Ethnopharmacol 109, 165-169.
14. Zhang Y, Li Q, Wan Hoi-Ying, et al. (2009) Genistein and a soy extract differentially affect three-dimensional bone parameters and bone-specific gene expression in ovariectomized mice. J Nutr 139, 2230-2236.
15. Zhang Y, Lai WP, Leung PC, et al. (2007) Short- to mid-term effects of ovariectomy on bone turnover, bone mass and bone strength in rats. Biol Pharm Bull 30, 898-903.
16. Zhang Y, Lai WP, Leung PC, et al. (2008) Improvement of Ca balance by Fructus Ligustri Lucidi extract in aged female rats. Osteoporos Int 19, 235-242.
17. Zhang Y, Dong XL, Leung PC, et al. (2009) Differential mRNA expression profiles in proximal tibia of aged rats in response to ovariectomy and low-Ca diet. Bone 44, 46-52.
18. Li XL (2004) Study of antiosteoporotic constituents of Erythrina variegata L. Master's Degree Thesis, Shenyang Pharmaceutical University.
19. Hie M, Shimono M, Fujii K, et al. (2007) Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats. Bone 41, 1045-1050.
20. Pennypacker B, Shea M, Liu Q, et al. (2009) Bone density, strength, and formation in adult cathepsin K (2/2) mice. Bone 44, 199-207.
21. Odvina CV, Poindexter JR, Peterson RD, et al. (2008) Intestinal hyperabsorption of calcium and low bone turnover in hypercalciuric postmenopausal osteoporosis. Urol Res 36, 233-239.
22. Sahota O, Mundey MK, San P, et al. (2004) The relationship between vitamin D and parathyroid hormone: Calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone 35, 312-319.
23. Leibbrandt A & Penninger JM (2008) RANK/RANKL: Regulators of immune responses and bone physiology. Ann N Y Acad Sci 1143, 123-150.
24. Hayman AR (2008) Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy. Autoimmunity 41, 218-223.