SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors

Biochemical and Biophysical Research Communications

Volumn 317, Issue 1, 2004, Pages 235-243

  Steiner, Elisabeth ^a   Holzmann, Klaus ^a   Pirker, Christine ^a   Elbling, Leonilla ^a   Micksche, Michael ^a   Berger, Walter ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Histone deacetylase inhibitor; Lung resistance related protein; Major vault protein; Promoter transactivation; Sodium butyrate; Sp1 transcriptional regulation

Indexed keywords

BUTYRIC ACID; HISTONE DEACETYLASE INHIBITOR; LUNG RESISTANCE PROTEIN; MITHRAMYCIN; MITHRAMYCIN A; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; GENE ACTIVATION; GENE ACTIVITY; GENE DELETION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; MUTAGENESIS; MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; STIMULATION; TRANSACTIVATION;

ANIMALS; BASE SEQUENCE; BUTYRATES; CELL LINE, TUMOR; CELLS, CULTURED; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MICE; PLICAMYCIN; PROMOTER REGIONS (GENETICS); RATS; RESPONSE ELEMENTS; SEQUENCE DELETION; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; TRANSFECTION; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 1642463448     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.03.029     Document Type: Article

References (39)

1. Suprenant K.A. Vault ribonucleoprotein particles: sarcophagi, gondolas, or safety deposit boxes? Biochemistry. 41:2002;14447-14454.
2. Kedersha N.L., Miquel M.C., Bittner D., Rome L.H. Vaults. II. Ribonucleoprotein structures are highly conserved among higher and lower eukaryotes. J. Cell. Biol. 110:1990;895-901.
3. Kong L.B., Siva A.C., Rome L.H., Stewart P.L. Structure of the vault, a ubiquitous celular component. Structure. 7:1999;371-379.
4. Chugani D.C., Rome L.H., Kedersha N.L. Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex. J. Cell Sci. 106:1993;23-29.
5. Hamill D.R., Suprenant K.A. Characterization of the sea urchin major vault protein: a possible role for vault ribonucleoprotein particles in nucleocytoplasmic transport. Dev. Biol. 190:1997;117-128.
6. Berger W., Spiegl Kreinecker S., Buchroithner J., Elbling L., Pirker C., Fischer J., Micksche M. Overexpression of the human major vault protein in astrocytic brain tumor cells. Int. J. Cancer. 94:2001;377-382.
7. Meijer G.A., Schroeijers A.B., Flens M.J., Meuwissen S.G., van der Valk P., Baak J.P., Scheper R.J. Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis. J. Clin. Pathol. 52:1999;450-454.
8. Yu Z., Fotouhi Ardakani N., Wu L., Maoui M., Wang S., Banville D., Shen S.H. PTEN associates with the vault particles in HeLa cells. J. Biol. Chem. 277:2002;40247-40252.
9. Scheffer G.L., Wijngaard P.L., Flens M.J., Izquierdo M.A., Slovak M.L., Pinedo H.M., Meijer C.J., Clevers H.C., Scheper R.J. The drug resistance-related protein LRP is the human major vault protein. Nat. Med. 1:1995;578-582.
10. Kickhoefer V.A., Rajavel K.S., Scheffer G.L., Dalton W.S., Scheper R.J., Rome L.H. Vaults are up-regulated in multidrug-resistant cancer cell lines. J. Biol. Chem. 273:1998;8971-8974.
11. Berger W., Elbling L., Micksche M. Expression of the major vault protein LRP in human non-small-cell lung cancer cells: activation by short-term exposure to antineoplastic drugs. Int. J. Cancer. 88:2000;293-300.
12. Kitazono M., Sumizawa T., Takebayashi Y., Chen Z.S., Furukawa T., Nagayama S., Tani A., Takao S., Aikou T., Akiyama S. Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells. J. Natl. Cancer Inst. 91:1999;1647-1653.
13. Holzmann K., Ambrosch I., Elbling L., Micksche M., Berger W. A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant. FEBS Lett. 494:2001;99-104.
14. Lange C., Walther W., Schwabe H., Stein U. Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter. Biochem. Biophys. Res. Commun. 278:2000;125-133.
15. Mossink M., van Zon A., Franzel Luiten E., Schoester M., Scheffer G.L., Scheper R.J., Sonneveld P., Wiemer E.A. The genomic sequence of the murine major vault protein and its promoter. Gene. 294:2002;225-232.
16. Suske G. Transient transfection of Schneider cells in the study of transcription factors. Methods Mol. Biol. 130:2000;175-187.
17. Doetzlhofer A., Rotheneder H., Lagger G., Koranda M., Kurtev V., Brosch G., Wintersberger E., Seiser C. Histone deacetylase 1 can repress transcription by binding to Sp1. Mol. Cell. Biol. 19:1999;5504-5511.
18. Berger W., Setinek U., Mohr T., Kindas-Mugge I., Vetterlein M., Dekan G., Eckersberger F., Caldas C., Micksche M. Evidence for a role of FGF-2 and FGF receptors in the proliferation of non-small cell lung cancer cells. Int. J. Cancer. 83:1999;415-423.
19. Holzmann K., Berger W., Mejri D., Cerni C., Sasgary S. Detection and quantification of transcripts for the catalytic subunit TERT and the RNA component of telomerase in rat tissue. Anal. Biochem. 317:2003;120-123.
20. Blume S.W., Snyder R.C., Ray R., Thomas S., Koller C.A., Miller D.M. Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J. Clin. Invest. 88:1991;1613-1621.
21. Courey A.J., Tjian R. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell. 55:1988;887-898.
22. Scheffer G.L., Schroeijers A.B., Izquierdo M.A., Wiemer E.A., Scheper R.J. Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer. Curr. Opin. Oncol. 12:2000;550-556.
23. Zurita A.J., Diestra J.E., Condom E., Garcia Del Muro X., Scheffer G.L., Scheper R.J., Perez J., Germa Lluch J.R., Izquierdo M.A. Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours. Br. J. Cancer. 88:2003;879-886.
24. Izquierdo M.A., Scheffer G.L., Flens M.J., Giaccone G., Broxterman H.J., Meijer C.J., van der Valk P., Scheper R.J. Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. Am. J. Pathol. 148:1996;877-887.
25. Zhang M.Q. Identification of human gene core promoters in silico. Genome Res. 8:1998;319-326.
26. Bouwman P., Philipsen S. Regulation of the activity of Sp1-related transcription factors. Mol. Cell. Endocrinol. 195:2002;27-38.
27. Cornwell M.M., Smith D.E. SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity. J. Biol. Chem. 268:1993;19505-19511.
28. Wang Q., Beck W.T. Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53. Cancer Res. 58:1998;5762-5769.
29. ′ -flanking region of human MRP3 Biochem. Biophys. Res. Commun. 270:2000;728-732.
30. Bailey Dell K.J., Hassel B., Doyle L.A., Ross D.D. Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochim. Biophys. Acta. 1520:2001;234-241.
31. Kadonaga J.T., Carner K.R., Masiarz F.R., Tjian R. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell. 51:1987;1079-1090.
32. Zhou T., Chiang C.M. Sp1 and AP2 regulate but do not constitute TATA-less human TAF(II)55 core promoter activity. Nucleic Acids Res. 30:2002;4145-4157.
33. Mantovani R. A survey of 178 NF-Y binding CCAAT boxes. Nucleic Acids Res. 26:1998;1135-1143.
34. Davie J.R. Inhibition of histone deacetylase activity by butyrate. J. Nutr. 133:2003;2485S-2493S.
35. Jung M. Inhibitors of histone deacetylase as new anticancer agents. Curr. Med. Chem. 8:2001;1505-1511.
36. Sowa Y., Orita T., Minamikawa Hiranabe S., Mizuno T., Nomura H., Sakai T. Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. Cancer Res. 59:1999;4266-4270.
37. Black A.R., Black J.D., Azizkhan Clifford J. Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer. J. Cell. Physiol. 188:2001;143-160.
38. Kim S.J., Onwuta U.S., Lee Y.I., Li R., Botchan M.R., Robbins P.D. The retinoblastoma gene product regulates Sp1-mediated transcription. Mol. Cell. Biol. 12:1992;2455-2463.
39. Suske G. The Sp-family of transcription factors. Gene. 238:1999;291-300.