A new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system

Toxicon

Volumn 56, Issue 7, 2010, Pages 1145-1154

  Chudzinski Tavassi, Ana Marisa ^a   De Sá Júnior, Paulo Luis ^a   Simons, Simone Michaela ^a   Maria, Durvanei Augusto ^a   de Souza Ventura, Janaina ^a   de Fátima Correia Batista, Isabel ^a   Faria, Fernanda ^a   Durães, Esther ^b   Reis, Eduardo Moraes ^b   Demasi, Marilene ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Amblyomin X; Amblyomma cajennense; Apoptosis; Proteasome inhibition; Tick

Indexed keywords

AMBLYOMIN X; ANTINEOPLASTIC AGENT; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE PROGRESSION; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SAFETY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MELANOMA; MELANOMA B16; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; IXODIDAE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; PROTEASOME ENDOPEPTIDASE COMPLEX; SALIVARY GLANDS; SALIVARY PROTEINS AND PEPTIDES; SERINE PROTEINASE INHIBITORS; UBIQUITIN;

AMBLYOMMA CAJENNENSE; IXODIDA; MURINAE;

EID: 77957914109     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.04.019     Document Type: Article

References (29)

1. Adams J. Potential for proteasome inhibition in the treatment of cancer. Drug. Discov. Today. 2003, 8:307-315.
2. Aragão H. Ixodidas brasileiros e de alguns países limitrophes. Memorias do Instituto Oswaldo Cruz. 1936, 31:759-844.
3. Bandyopadhyay A., Zhu Y., Malik S.N., Kreisberg J., Brattain M.G., Sprague E.A., Luo J., López-Casillas F., Sun L.Z. Extracellular domain of TGF beta type III receptor inhibits angiogenesis and tumor growth in human cancer cells. Oncogene. 2002, 21:3541-3551.
4. Batista I.F.C., Chudzinski-Tavassi A.M., Faria F., Simons S.M., Barros-Batestti D.M., Labruna M.B., Leão L.I., Ho P.L., Junqueira-de-Azevedo I.L.M. Expressed sequence tags (ESTs) from the salivary glands of the tick Amblyomma cajennense (Acari: Ixodidae). Toxicon 2008, 51:823-834.
5. Batista I.F.C., Ramos O.H.P., Ventura J.S., Junqueira-de-Azevedo I.L.M., Ho P.L., Chudzinski-Tavassi A.M. A new factor Xa inhibitor from Amblyomma cajennense with a unique domain composition. Arc. Biochem. Biophys. 2010, 493:151-156.
6. Bold R.J., Virudachalam S., McConkey D.J. Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome. J. Surg. Res. 2001, 100:11-17.
7. Bolstad B.M., Irizarry R.A., Astrand M., Speed T.P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003, 19:185-193.
8. Francischetti I.M., Sa-Nunes A., Mans B.J., Santos I.M., Ribeiro J.M. The role of saliva in tick feeding. Front Biosci. 2009, 14:2051-2088.
9. Francischetti I.M., Valenzuela J.G., Andersen J.F., Mather T.N., Ribeiro J.M. Ixolaris, a novel recombinant tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick, Ixodes scapularis: identification of factor X and factor Xa as scaffolds for the inhibition of factor VIIa/tissue factor complex. Blood 2002, 99:3602-3612.
10. Golub T.R., Slonim D.K., Tamayo P., Huard C., Gaasenbeek M., Mesirov J.P., Coller H., Loh M.L., Downing J.R., Caligiuri M.A., Bloomfield C.D., Lander E.S. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999, 286:531-537.
11. Han X., Girard T.J., Baum P., Abendschein D.R., Broze- G.J. Structural requirements for TFPI-mediated inhibition of neointimal thickening after balloon injury in the rat. Arterioscler. Thromb. Vasc. Biol. 1999, 19:2563-2567.
12. Hembrough T.A., Swartz G.M., Papathanassiu A., Vlasuk G.P., Rote W.E., Green S.J., Pribluda V.S. Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism. Cancer Res. 2003, 63(11):2997-3000.
13. Hoshiya Y., Gupta V., Kawakubo H., Brachtel E., Carey J.L., Sasur L., Scott A., Donahoe P.K., Maheswaran S. Mullerian inhibiting substance promotes interferon gamma-induced gene expression and apoptosis in breast cancer cells. J. Biol. Chem. 2003, 278:51703-51712.
14. Hovius J.W., Levi M., Fikrig E. Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Med. 2008, 5:e43.
15. Huynh H., Ng C.Y., Ong C.K., Lim K.B., Chan T.W. Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland. Endocrinology 2001, 142:3607-3615.
16. Kawakubo H., Carey J.L., Brachtel E., Gupta V., Green J.E., Walden P.D., Maheswaran S. Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer. Oncogene. 2004, 23:8310-8319.
17. Li G., Satyamoorthy K., Herlyn M. Dynamics of cell interactions and communications during melanoma development. Crit Rev. Oral. Biol. Med. 2002, 13:62-70.
18. Liu F., Dowling M., Yang X.J., Kao G.D. Caspase-mediated specific cleavage of human histone deacetylase 4. J. Biol. Chem. 2004, 279:34537-34546.
19. Meiners S., Heyken D., Weller A., Ludwig A., Stangl K., Kloetzel P.M., Kruger E. Inhibition of proteasome activity induces concerted of proteasome genes and de novo formation of Mammalian proteasomes. J. Biol. Chem. 2003, 278:21517-21525.
20. Moore B.S., Eustáquio A.S., McGlinchey R.P. Advances in and applications of proteasome inhibitors. Curr. Opin. Chem. Biol. 2008, 12:434-440.
21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 1983, 65:55-63.
22. Nawrocki S.T., Sweeney-Gotsch B., Takamori R., McConkey D.J. The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts. Mol. Cancer Ther. 2004, 3:59-70.
23. Ong C.K., Ng C.Y., Leong C., Ng C.P., Foo K.T., Tan P.H., Huynh H. Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis. J. Biol. Chem. 2004, 279:743-754.
24. Salemink I., Franssen J., Willems G.M., Hemker H.C., Lindhout T. Inhibition of tissue factor-factor VIIa-catalyzed factor X activation by factor Xa-tissue factor pathway inhibitor. A rotating disc study on the effect of phospholipid membrane composition. J. Biol. Chem. 1999, 274:28225-28232.
25. Satyamoorthy K., Herlyn M. Cellular and molecular biology of human melanoma. Cancer Biol. Ther. 2002, 1:4-17.
26. Shiah H.S., Lee W.S., Juang S.H., Hong P.C., Lung C.C., Chang C.J., Chou K.M., Chang J.Y. Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036. Biochem. Pharmacol. 2007, 73:610-619.
27. Tsui K.H., Hsieh W.C., Lin M.H., Chang P.L., Juang H.H. Triiodothyronine modulates cell proliferation of human prostatic carcinoma cells by downregulation of the B-cell translocation gene 2. Prostate. 2008, 68:610-619.
28. Tuszynski G.P., Gasic T.B., Gasic G.J. Isolation and characterization of antistasin. An inhibitor of metastasis and coagulation. J. Biol. Chem. 1987, 262(20):9718-9723.
29. Wang H., Fu W., Im J.H., Zhou Z., Santoro S.A., Iyer V., DiPersio C.M., Yu Q.C., Quaranta V., Al-Mehdi A., Muschel R.J. Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. Cell Biol. 2004, 164:935-941.