Epstein Barr virus inhibits the stimulatory effect of TLR7/8 and TLR9 agonists but not CD40 ligand in human B lymphocytes

Microbiology and Immunology

Volumn 54, Issue 9, 2010, Pages 534-541

  Younesi, Vahid ^a   Nikzamir, Haleh ^a   Yousefi, Mehdi ^a   Khoshnoodi, Jalal ^a   Arjmand, Mohammd ^b   Rabbani, Hodjatallah ^c   Shokri, Fazel ^a,b,c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

^c SHAHID BEHESHTI UNIVERSITY   (Iran)

Author keywords

CD40 ligand; CpG; Epstein barr virus; Toll like receptor

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; MESSENGER RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TLR7 PROTEIN, HUMAN; TLR8 PROTEIN, HUMAN; TLR9 PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INHIBITION KINETICS; LYMPHOCYTE PROLIFERATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRUS IMMUNITY; AGONISTS; CELL CULTURE; CYTOLOGY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PATHOGENICITY; PHYSIOLOGY;

EQUUS ASINUS; HUMAN HERPESVIRUS 4;

APOPTOSIS; B-LYMPHOCYTES; CD40 LIGAND; CELLS, CULTURED; HERPESVIRUS 4, HUMAN; HUMANS; LYMPHOCYTE ACTIVATION; NF-KAPPA B; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TOLL-LIKE RECEPTOR 9;

EID: 77957892608     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2010.00248.x     Document Type: Article

References (41)

1. Young L.S., Rickinson A.B. (2004) Epstein-Barr virus: 40 years on. Nat Rev Cancer 4: 757-68.
2. Middeldorp J.M., Brink A.A., Van Den Brule A.J., Meijer C.J. (2003) Pathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disorders. Crit Rev Oncol Hematol 45: 1-36.
3. Bishop G.A., Busch L.K. (2000) Molecular mechanisms of B-lymphocyte transformation by Epstein-Barr virus. Microbes Infect 4: 853-7.
4. Wensing B., Farrell P.J. (2000) Regulation of cell growth and death by Epstein-Barr virus. Microbes Infect 2: 77-84.
5. Rastelli J., Homig-Holzel C., Seagal J., Muller W., Hermann A.C., Rajewsky K. et al. (2008) LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1. Blood 111: 1448-55.
6. Adler B., Schaadt E., Kempkes B., Zimber-Strobl U., Baier B., Bornkamm GW. (2002) Control of Epstein-Barr virus reactivation by activated CD40 and viral latent membrane protein 1. Proc Natl Acad Sci U S A 99: 437-42.
7. Imadome K., Shirakata M., Shimizu N., Nonoyama S., Yamanashi Y. (2003) CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation. Proc Natl Acad Sci U S A 100: 7836-40.
8. Bowie AG., Unterholzner L. (2008) Viral evasion and subversion of pattern-recognition receptor signalling. Nat Rev Immunol 8: 911-22.
9. Unterholzner L., Bowie AG. (2008) The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities. Biochem Pharmacol 75: 589-602.
10. Kawai T., Akira S. (2006) Innate immune recognition of viral infection. Nat Immunol 7: 131-7.
11. Jiang W., Lederman M.M., Harding C.V., Rodriguez B, Mohner R.J., Sieg SF. (2007) TLR9 stimulation drives naive B cells to proliferate and to attain enhanced antigen presenting function. Eur J Immunol 37: 2205-13.
12. Ruprecht C.R., Lanzavecchia A. (2006) Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol 36: 810-16.
13. Finberg R.W., Wang J.P., Kurt-Jones E.A. (2007) Toll like receptors and viruses. Rev Med Virol 17: 35-43.
14. Lund J., Sato A., Akira S., Medzhitov R., Iwasaki A. (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198: 513-20.
15. Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K. et al. (2004) Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A 101: 3516-21.
16. Krug A., Luker G.D., Barchet W., Leib D.A., Akira S., Colonna M. (2004) Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103: 1433-7.
17. Hiscott J., Nguyen T.L., Arguello M., Nakhaei P., Paz S. (2006) Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses. Oncogene 25: 6844-67.
18. Lim W.H, Kireta S., Russ G.R., Coates P.T. (2007) Human plasmacytoid dendritic cells regulate immune responses to Epstein-Barr virus (EBV) infection and delay EBV-related mortality in humanized NOD-SCID mice. Blood 109: 1043-50.
19. Guggemoos S., Hangel D., Hamm S., Heit A, Bauer S., Adler H. (2008) TLR9 contributes to antiviral immunity during gammaherpesvirus infection. J Immunol 180: 438-43.
20. Bowie A.G., Haga I.R. (2005) The role of Toll-like receptors in the host response to viruses. Mol Immunol 42: 859-67.
21. Brown H.J., Song M.J., Deng H., Wu T.T., Cheng G., Sun R. (2003) NF-kappaB inhibits gammaherpesvirus lytic replication. J Virol 77: 8532-40.
22. Ladell K., Dorner M., Zauner L., Berger C., Zucol F., Bernasconi M. et al. (2007) Immune activation suppresses initiation of lytic Epstein-Barr virus infection. Cell Microbiol 9: 2055-69.
23. Martin H.J., Lee J.M., Walls D., Hayward S.D. (2007) Manipulation of the toll-like receptor 7 signaling pathway by Epstein-Barr virus. J Virol 81: 9748-58.
24. Gharagozlou S., Kardar G.A., Rabbani H., Shokri F. (2005) Molecular analysis of the heavy chain variable region genes of human hybridoma clones specific for coagulation factor VIII. Thromb Haemost 94: 1131-7.
25. Kazemi T., Asgarian-Omran H., Hojjat-Farsangi M., Shabani M., Memarian A., Sharifian R.A. et al. (2008) Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia. Int J Cancer 123: 2113-9.
26. Shokri F., Mageed R.A., Maziak B.R., Jefferis R. (1991) Expression of VHIII-associated cross-reactive idiotype on human B lymphocytes. Association with staphylococcal protein A binding and Staphylococcus aureus Cowan I stimulation. J Immunol 146: 936-40.
27. Shokrgozar MA., Shokri F. (2001) Enumeration of hepatitis B surface antigen-specific B lymphocytes in responder and non-responder normal individuals vaccinated with recombinant hepatitis B surface antigen. Immunology 104: 75-9.
28. Young S.L., Lyddon T.D., Jorgenson R.L., Misfeldt M.L. (2004) Expression of Toll-like receptors in human endometrial epithelial cells and cell lines. Am J Reprod Immunol 52: 67-73.
29. Boehme K.W., Compton T. (2004) Innate sensing of viruses by toll-like receptors. J Virol 78: 7867-73.
30. Hiscott J., Kwon H., Genin P. (2001) Hostile takeovers: viral appropriation of the NF-kappaB pathway. J Clin Invest 107: 143-51.
31. Bowie A., Kiss-Toth E., Symons J.A., Smith G.L., Dower S.K., O'Neill L.A. (2000) A46R and A52R from Vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci U S A 97: 10162-7.
32. Haga I.R., Bowie A.G. (2005) Evasion of innate immunity by Vaccinia virus. Parasitology 130(Suppl): S11-25.
33. Harte M.T., Haga I.R., Maloney G., Gray P., Reading P.C., Bartlett N.W. et al. (2003) The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J Exp Med 197: 343-51.
34. Li K., Foy E., Ferreon J.C., Nakamura M., Ferreon A.C., Ikeda M. et al. (2005) Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A 102: 2992-7.
35. Abe T., Kaname Y., Hamamoto I., Tsuda Y., Wen X., Taguwa S. et al. (2007) Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines. J Virol 81: 8953-66.
36. Daubeuf S., Singh D., Tan Y., Liu H., Federoff H.J., Bowers W.J. et al. (2009) HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood 113:3264-75.
37. Wiesner M., Zentz C., Mayr C., Wimmer R., Hammerschmidt W., Zeidler R. et al. (2008) Conditional immortalization of human B cells by CD40 ligation. PLoS One 3: e1464.
38. Tomai M.A., Imbertson L.M., Stanczak T.L., Tygrett L.T., Waldschmidt T.J. (2000) The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes. Cell Immunol 203: 55-65.
39. Indoh T., Yokota S., Okabayashi T., Yokosawa N., Fujii N. (2007) Suppression of NF-kappaB and AP-1 activation in monocytic cells persistently infected with measles virus. Virology 361: 294-303.
40. Yokota S., Okabayashi T., Yokosawa N., Fujii N. (2008) Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20. Faseb J 22: 74-83.
41. Laherty C.D., Hu H.M., Opipari A.W., Wang F., Dixit V.M. (1992) The Epstein-Barr virus LMPl gene product induces A20 zinc finger protein expression by activating nuclear factor KB. J Biol Chem 267: 24157-60.