TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function

European Journal of Immunology

Volumn 37, Issue 8, 2007, Pages 2205-2213

  Jiang, Wei ^a   Lederman, Michael M ^a   Harding, Clifford V ^b   Rodriguez, Benigno ^a   Mohner, Richard J ^a   Sieg, Scott F ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Adjuvants; B cells; Cellular proliferation; CpG ODN

Indexed keywords

B LYMPHOCYTE RECEPTOR; B7 ANTIGEN; CD27 ANTIGEN; CD40 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; HLA DR ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; TOLL LIKE RECEPTOR 9;

ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL INTERACTION; CELL SURVIVAL; CELL TYPE; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANTIGEN PRESENTATION; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMANS; IMMUNOMAGNETIC SEPARATION; LYMPHOCYTE ACTIVATION; OLIGODEOXYRIBONUCLEOTIDES; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 9;

EID: 34547881895     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636984     Document Type: Article

References (23)

1. Krieg, A. M., CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 2002. 20: 709-760.
2. Bernasconi, N. L, Traggiai, E. and Lanzavecchia, A., Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002. 298: 2199-2202.
3. Parker, D. C., T cell-dependent B cell activation. Annu. Rev. Immunol. 1993. 11: 331-360.
4. Fillatreau, S. and Manz, R. A., Toils for B cells. Eur. J. Immunol. 2006. 36: 798-801.
5. Wirths, S. and Lanzaveechia, A., ABCB1 traWorter discriminates human resting naïve B cells from cycling transitional and memory B cells. Eur. J. Immunol. 2005. 35: 3433-3441.
6. Landers, C D. and Bondada, S., CpG oligodeoxynucleotides stimulate cord blood mononuclear cells to produce immunoglobulins. Clin. Immunol. 2005. 116: 236-245.
7. Vollmer, J., Weeratna, R. D., Jurk, M., Samulowitz, U., McCluskie, M. J., Payette, P., Davis, H. L. et al., Oligodeoxynucleotides lacking CpG dinucleoddes mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation. Immunology 2004. 113: 212-223.
8. Malaspina, A., Moir, S., Ho, J., Wang, W., Howell, M. L., O'Shea, M. A., Roby, G. A. et al., Appearance of immature transitional B cells in HIV-infected individuals with advanced disease: Correlation with increased IL-7. Proc. Natl. Acad. Sci. USA 2006. 103: 2262-2267.
9. Jiang, W., Lederman, M. M., Salkowitz, J. R., Rodriguez, B., Harding, C. V. and Sieg, S. F., Impaired monocyte maturation in response to CpG oligodeoxynudeotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially mediated by deficiencies in alpha/beta interferon responsiveness and production. J. Virol. 2005. 79: 4109-4119.
10. Poeck, H., Wagner, M., Battlany, J., Rothenfusser, S., Wellisch, D., Hornung, V., Jahrsdorfer, B. et al., Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 2004. 103: 3058-3064.
11. Wagner, E. F., Hanna N., Fast, L. D., Kouttab, N., Shank, P. R., Vazquez, A. and Sharma S., Novel diversity in IL-4-mediated response in resting human naïve B cells vemw germinal center/memory B cells. J. Immunol. 2000. 165: 5573-5579.
12. Huggins, J., Pellegrin, T., Felgar, R. E., Wel, C., Brovm, M., Zheng, B., Milner, E. C. et al., CpG DNA activation and plasma-cell differentiation of CD27- naïve human B cells. Blood 20O7. 109: 1611-1619.
13. Bekeredjian-Ding, I. B., Wagner, M., Hornung, V., Giese, T., Schnurr, M., Endres, S. and Hartmann, G., Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN. J. Immunol. 2005. 174: 4043-4050.
14. Tasker, L. and Marshall-Clarke, S., Functional responses of human neonatal B lymphocytes to antigen receptor cross-linking and CpG DNA. Clin. Exp. Immunol. 2003. 134: 409-419.
15. Bernasconi, N. L., Onai, N. and Lanzaveechia, A., A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naïve B cells and constitutive expression in memory B cells. Blood 2003. 101: 4500-4504.
16. Fayette, J., Durand, I., Bridon, J. M., Arpin, C., Dubois, B., Caux, C., Liu, Y. J. et al., Dendritic cells enhance the differentiation of naïve B cells into plasma cells in vitro. Scand. J. Immunol. 1998. 48: 563-570.
17. Rajewsky, K., Clonal selection and learning in the antibody system. Nature 1996. 381: 751-758.
18. Forster, I., Muller, W., Schittek, B. and Rojewsky, K., Generation of long-lived B cells in germ-free mice. Eur. J. Immunol. 1991. 21: 1779-1782.
19. Macallan D. C., Wallace, D. L, Zhang, Y., Ghattas, H., Asquith, B., de Lara, C., Worth, A. et al., B-cell kinetics in humans: Rapid turnover of peripheral blood memory cells. Blood 2005. 105: 3633-3640.
20. Ridge, J. P., Fuchs, E. J. and Matzinger, P., Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells. Science 1996. 271: 1723-1726.
21. Kuchtey, J., Pennini, M., Pai, R. K. and Harding, C. V., CpG DNA induces a class II transactivator-indepenclent increase in class II MHC by stabilizing class II MHC mRNA in B lymphocytes. J. Immunol. 2003. 171: 2320-2325.
22. + T cells and B cells as APC. Int. Immunol. 2006. 18: 719-728.
23. Yuschenkoff, V. N., Sethna, M. P., Freeman, G. J. and Parker, D. C., Coexpression of B7-1 and antigen blocks tolerance induction to antigen presented by resting B cells. J. Immunol. 1996. 157: 1987-1995.