Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha

Neuroscience Letters

Volumn 308, Issue 1, 2001, Pages 41-44

  Ahn, Meejung ^a   Kang, Jongchul ^a   Lee, Yongduk ^a   Riu, Keyzung ^a   Kim, Yong sik ^b   Jee, Youngheun ^c   Matsumoto, Yoh ^c   Shin, Taekyun ^a  

^a Jeju National University   (South Korea)

^b Seoul National University   (South Korea)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Experimental autoimmune encephalomyelitis; Inducible nitric oxide synthase; Pertussis toxin; Tumor necrosis factor alpha

Indexed keywords

MESSENGER RNA; NITRIC OXIDE SYNTHASE; PERTUSSIS TOXIN; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD; WESTERN BLOTTING;

ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; MACROPHAGES; MULTIPLE SCLEROSIS; NITRIC OXIDE SYNTHASE; PERTUSSIS TOXIN; RATS; RATS, INBRED LEW; SPINAL CORD; TUMOR NECROSIS FACTOR-ALPHA; VIRULENCE FACTORS, BORDETELLA;

EID: 0035958826     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01979-6     Document Type: Article

References (20)

1. Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration
2. Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene
3. Cloning and expression of nitric oxide synthase from rat astrocytes
4. 1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis
5. T-lymphocyte entry into the central nervous system
6. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic disease
7. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
8. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme
9. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line
10. Nitric oxide: Physiology, pathophysiology and pharmacology
11. Regulation of biosynthesis of nitric oxide
12. Expression of a dominant-negative mutant of p21ras inhibits induction of nitric oxide synthase and activation of nuclear factor-kappaB in primary astrocytes
13. Apoptosis of alpha/beta T lymphocytes in the nervous system in experimental autoimmune encephalomyelitis: Its possible implication for recovery and acquired tolerance
14. The analysis of autoimmune demyelination: Its impact on multiple sclerosis
15. The effect of Freund's adjuvant on blood-cerebrospinal fluid barrier permeability
16. Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain
17. CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages
18. Competitive PCR quantification of pro- and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis
19. Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis
20. Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase