Unique Th1/Th2 phenotypes induced during priming and memory phases by use of interleukin-12 (IL-12) or IL-28B vaccine adjuvants in rhesus macaques

Clinical and Vaccine Immunology

Volumn 17, Issue 10, 2010, Pages 1493-1499

  Morrow, Matthew P ^a   Yan, Jian ^a   Pankhong, Panyupa ^a   Ferraro, Bernadette ^a   Lewis, Mark G ^b   Khan, Amir S ^c   Sardesai, Niranjan Y ^c   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BIOQUAL INC   (United States)

^c Inovio Biomedical Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 28; INTERLEUKIN 28B; INTERLEUKIN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; DNA IMMUNIZATION; DRUG ANALYSIS; DRUG MECHANISM; IMMUNE RESPONSE; IMMUNE SYSTEM; INTERFERON PRODUCTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RHESUS MONKEY; TH1 CELL; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CYTOKINES; INTERLEUKIN-12; MACACA MULATTA; TH1 CELLS; TH2 CELLS; TIME FACTORS; VACCINES;

EID: 77957873008     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00181-10     Document Type: Article

References (16)

1. Belyakov, I. M., M. A. Derby, J. D. Ahlers, B. L. Kelsall, P. Earl, B. Moss, W. Strober, and J. A. Berzofsky. 1998. Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge. Proc. Natl. Acad. Sci. U. S. A. 95:1709-1714.
2. Boyer, J. D., T. M. Robinson, M. A. Kutzler, R. Parkinson, S. A. Calarota, M. K. Sidhu, K. Muthumani, M. Lewis, G. Pavlakis, B. Felber, and D. Weiner. 2005. SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques. J. Med. Primatol. 34:262-270.
3. Chong, S. Y., M. A. Egan, M. A. Kutzler, S. Megati, A. Masood, V. Roopchard, D. Garcia-Hand, D. C. Montefiori, J. Quiroz, M. Rosati, E. B. Schadeck, J. D. Boyer, G. N. Pavlakis, D. B. Weiner, M. Sidhu, J. H. Eldridge, and Z. R. Israel. 2007. Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques. Vaccine 25:4967-4982.
4. Dubie, R. A., S. Maksaereekul, B. L. Shacklett, D. Lemongello, K. S. Cole, F. Villinger, S. A. Blozis, P. A. Luciw, and E. E. Sparger. 2009. Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. Virology 386:109-121.
5. Faries, M. B., E. C. Hsueh, X. Ye, M. Hoban, and D. L. Morton. 2009. Effect of granulocyte/macrophage colony-stimulating factor on vaccination with an allogeneic whole-cell melanoma vaccine. Clin. Cancer Res. 15:7029-7035.
6. Greenland, J. R., and N. L. Letvin. 2007. Chemical adjuvants for plasmid DNA vaccines. Vaccine 25:3731-3741.
7. Hirao, L. A., L. Wu, A. S. Khan, D. A. Hokey, J. Yan, A. Dai, M. R. Betts, R. Draghia-Akli, and D. B. Weiner. 2008. Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques. Vaccine 26:3112-3120.
8. Kim, J. J., H. C. Maguire, Jr., L. K. Nottingham, L. D. Morrison, A. Tsai, J. I. Sin, A. A. Chalian, and D. B. Weiner. 1998. Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype. J. Interferon Cytokine Res. 18:537-547.
9. Kraynyak, K. A., M. A. Kutzler, N. J. Cisper, D. J. Laddy, M. P. Morrow, T. A. Waldmann, and D. B. Weiner. 2009. Plasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo. Hum. Gene Ther. 20:1143-1156.
10. Morrow, M. P., P. Pankhong, D. J. Laddy, K. A. Schoenly, J. Yan, N. Cisper, and D. B. Weiner. 2009. Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity. Blood 113:5868-5877.
11. Morrow, M. P., and D. B. Weiner. 2008. Cytokines as adjuvants for improving anti-HIV responses. AIDS 22:333-338.
12. Morrow, M. P., J. Yan, P. Pankhong, D. J. Shedlock, M. G. Lewis, K. Talbott, R. Toporovski, A. S. Khan, N. Y. Sardesai, and D. B. Weiner. 22 June 2010. IL-28B/IFN-lambda3 drives granzyme B loading and significantly increases CTL killing activity in macaques. Mol. Ther. [Epub ahead of print.]
13. Ramos, H. J., A. M. Davis, A. G. Cole, J. D. Schatzle, J. Forman, and J. D. Farrar. 2009. Reciprocal responsiveness to interleukin-12 and interferon-alpha specifies human CD8+ effector versus central memory T-cell fates. Blood 113:5516-5525.
14. Schadeck, E. B., M. Sidhu, M. A. Egan, S. Y. Chong, P. Piacente, A. Masood, D. Garcia-Hand, S. Cappello, V. Roopchand, S. Megati, J. Quiroz, J. D. Boyer, B. K. Felber, G. N. Pavlakis, D. B. Weiner, J. H. Eldridge, and Z. R. Israel. 2006. A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques. Vaccine 24:4677-4687.
15. Serre, K., E. Mohr, F. Gaspal, P. J. Lane, R. Bird, A. F. Cunningham, and I. C. Maclennan. 13 April 2010. IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo. Mol. Immunol. [Epub ahead of print.]
16. Sin, J. I., J. J. Kim, R. L. Arnold, K. E. Shroff, D. McCallus, C. Pachuk, S. P. McElhiney, M. W. Wolf, S. J. Pompa-de Bruin, T. J. Higgins, R. B. Ciccarelli, and D. B. Weiner. 1999. IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model: IL-12 enhances Th1-type CD4+ T cell-mediated protective immunity against herpes simplex virus-2 challenge. J. Immunol. 162:2912-2921.