In vivo metabolism study of rhubarb decoction in rat using high-performance liquid chromatography with UV photodiode-array and mass-spectrometric detection: A strategy for systematic analysis of metabolites from traditional Chinese medicines in biological samples

Journal of Chromatography A

Volumn 1217, Issue 45, 2010, Pages 7144-7152

  Song, Rui ^a   Xu, Lei ^a   Xu, Fengguo ^a   Li, Zhe ^a   Dong, Haijuan ^a   Tian, Yuan ^a   Zhang, Zunjian ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

HPLC DAD; HPLC MS MS; In vivo metabolism; Metabolites; Rhubarb decoction

Indexed keywords

BIOLOGICAL SAMPLES; CLINICAL STUDY; DIODE ARRAY DETECTION; EPICATECHIN; GALLIC ACIDS; GLUCURONIDATION; HPLC-DAD; HPLC-MS/MS; IN-VIVO; MASS SPECTROMETRIC DETECTION; METABOLIC PATHWAYS; ORAL ADMINISTRATION; PHASE I; PHASE II; PHENOLIC COMPOUNDS; RAT URINE; RHUBARB DECOCTION; SEPARATION AND IDENTIFICATION; SPECTROMETRIC ANALYSIS; STRUCTURE ELUCIDATION; SYSTEMATIC ANALYSIS; TANDEM MASS SPECTROMETRY; TRADITIONAL CHINESE MEDICINE;

ACIDS; BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KETONES; LIQUIDS; MASS SPECTROMETRY; MEDICINE; METABOLITES; PHENOLS;

METABOLISM;

ALOE EMODIN; ANTHRAQUINONE DERIVATIVE; CATECHIN; CHRYSOPHANIC ACID; DRUG METABOLITE; EMODIN; EPICATECHIN; GALLIC ACID; PHYSCION; RHEIN; RHUBARB EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SULFATION; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; METHYLATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ANTHRAQUINONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; FLAVONOIDS; GALLIC ACID; MALE; MASS SPECTROMETRY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; RHEUM; SPECTROPHOTOMETRY, ULTRAVIOLET; URINE;

RATTUS; RHEUM X HYBRIDUM;

EID: 77957858384     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.09.028     Document Type: Article

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