Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 5420-5427

  Lee, Kyungik ^a,b   Jeong, Ki Woong ^a   Lee, Yeonjoo ^b   Song, Ji Yeon ^b   Kim, Maeng Sup ^b   Lee, Gwan Sun ^b   Kim, Yangmee ^a  

^a Konkuk University   (South Korea)

^b Hanmi Pharmaceutical Co Ltd   (South Korea)

Author keywords

Anticancer activity; Docking; Kinase inhibitor; VEGFR 2; Virtual screening

Indexed keywords

6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; AAL 993; ABC TRANSPORTER; AG 028262; ANTINEOPLASTIC AGENT; AXITINIB; BAY 57 9352; CEDIRANIB; E 7080; KRN 951; L 000021649; MOTESANIB; PAZOPANIB; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN RECEPTOR 2; VATALANIB;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPUTER MODEL; DATA BASE; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ASSAY; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; MOLECULAR LIBRARY; PHARMACOPHORE; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

DRUG EVALUATION, PRECLINICAL; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 77957841701     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.002     Document Type: Article

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