Preparation of new polycyclic compounds derived from benzofurans and furochromones. An approach to novel 1,2,3-thia-, and selena-diazolofurochromones of anticipated antitumor activities

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 4920-4927

  Atta, Sanaa M Sh ^a   Farrag, Dalia S ^a   Sweed, Ayman M K ^a   Abdel Rahman, A H ^b  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b Mansoura University   (Egypt)

Author keywords

1,2,3 Selenadiazoles; 1,2,3 Thiadiazoles; Antitumor activity; Benzofurans; Furochromenes

Indexed keywords

10 METHOXY 4,4 DIMETHYL 4H FURO[2',3':7,6]CHROMENO[4,3-D][1,2,3]SELENADIAZOLE; 10' METHOXY SPIRO[CYCLOHEXANE 1,4' FURO[2',3':7,6]CHROMENO[4, 3 D][1,2,3]THIADIAZOLE]; 10' METHOXY SPIRO[CYCLOHEXANE 1,4' FURO[2',3':7,6]CHROMENO[4,3 D][1,2,3]SELENADIAZOLE]; 2 (7 ETHYL 4,9 DIMETHOXY 7 METHYL 6,7 DIHYDRO 5H FURO[3,2 G]CHROMEN 5 YLIDENE)HYDRAZINECARBOXAMIDE; 2 [1 (6 HYDROXY 4 METHOXYBENZOFURAN 5 YL) 3 (PYRROLIDIN 1 YL) BUT 2 ENYLIDENE] 1H INDENE 1,3(2H) DIONE; 2 [1 (6 HYDROXY 4,7 DIMETHOXYBENZOFURAN 5 YL) 3 (PYRROLIDIN 1 YL) BUT 2 ENYLIDENE] 1H INDENE 1,3(2H) DIONE; 2 [4 METHOXY 7,7 DIMETHYL 6,7 DIHYDRO 5H FURO[3,2 G]CHROMEN 5 YLIDENE]HYDRAZINECARBOXAMIDE; 2 [4' METHOXY SPIRO[CYCLOHEXANE 1,7' FURO[3,2 G]CHROMENE] 5'(6'H) YLIDENE]HYDRAZINECARBOXAMIDE; 2 [4',9' DIMETHOXY SPIRO[CYCLOHEXANE 1,7' FURO[3,2 G]CHROMENE] 5'(6'H) YLIDENE]HYDRAZINECARBOXAMIDE; 2 [4,9 DIMETHOXY 7,7 DIMETHYL 6,7 DIHYDRO 5H FURO[3,2 G]CHROMEN 5 YLIDENE]HYDRAZINECARBOXAMIDE; 4 ETHYL 6,10 DIMETHOXY 4 METHYL 4H FURO[2',3':7,6]CHROMENO[4,3 D][1,2,3]SELENADIAZOLE; 6',10' DIMETHOXY SPIRO[CYCLOHEXANE 1,4' FURO[2',3':7,6]CHROMENO[4, 3 D][1,2,3]THIADIAZOLE]; 6',10' DIMETHOXY SPIRO[CYCLOHEXANE 1,4' FURO[2',3':7,6]CHROMENO[4,3 D] [1,2,3]SELENADIAZOLE]; 6,10 DIMETHOXY 4,4 DIMETHYL 4H FURO[2',3':7,6]CHROMENO[4,3 D][1,2,3]SELENADIAZOLE; 7 ETHYL 4,9 DIMETHOXY 7 METHYL 6,7 DIHYDRO 5HFURO[3,2 G]CHROMEN 5 ONE; 7 IMINO 4 METHOXY 5 [2 (PYRROLIDIN 1 YL)PROP 1 ENYL] 7H FURO[3,2 G]CHROMENE 6 CARBONITRILE; 7 IMINO 4,9 DIMETHOXY 5 [ 2 (PYRROLIDIN 1 YL)PROP 1 ENYL] 7H FURO[3,2 G]CHROMENE 6 CARBONITRILE; ANTINEOPLASTIC AGENT; BENZOFURAN DERIVATIVE; CYCLOPENTA 2,4 DIENYL[2 [3 (6 HYDROXY 4 METHOXYBENZOFURAN 5 YL) 3 OXOPROP 1 ENYL]CYCLOPENTA 2,4 DIENYL]IRON; CYCLOPENTA 2,4 DIENYL[2 [3 (6 HYDROXY 4,7 DIMETHOXYBENZOFURAN 5 YL) 3 OXOPROP 1 ENYL]CYCLOPENTA 2,4 DIENYL]IRON; DOXORUBICIN; FUROCHROMONE DERIVATIVE; MALONONITRILE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HCT116; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL;

BENZOFURANS; CHROMONES; MAGNETIC RESONANCE SPECTROSCOPY; POLYCYCLIC COMPOUNDS;

EID: 77957839109     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.07.065     Document Type: Article

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