Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 5208-5216

  Myadaraboina, Shailaja ^a   Alla, Manjula ^a   Saddanapu, Venkateshwarlu ^a   Bommena, Vittal Rao ^a   Addlagatta, Anthony ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Anticancer activity; Imidazo 1,2 a pyrazine; Inhibitor design; Structure activity relationship; Synthesis

Indexed keywords

(4 FLUOROPHENYL) 6 METHYL 2 PHENYLIMIDAZO[1,2 A]PYRAZINE; 2 (4 CHLOROPHENYL) 6 METHYLIMIDAZO[1,2 A]PYRAZINE 3 CARBONITRILE; 2 (4 FLUOROPHENYL) 6 METHYL 3 (MORPHOLINOMETHYL)IMIDAZO[1,2 A]PYRAZINE; 2 (4 FLUOROPHENYL) 6 METHYL METHYLIMIDAZO[1,2 A]PYRAZINE 3 CARBONITRILE; 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRAZINE; 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRAZINE 3 CARBONITRILE; 2 4 TOLYLIMIDAZO[1,2 A]PYRAZINE; 2 [4 (BENZYLOXY) 3 NITROPHENYL] 6 METHYLIMIDAZO[1,2 A]PYRAZINE; 2 [4 (BENZYLOXY) 3 NITROPHENYL]IMIDAZO[1,2 A]PYRAZINE 3 CARBONITRILE; 2 BROMO 6 METHYL 2 PHENYLIMIDAZO[1,2 A]PYRAZINE; 2 PHENYLIMIDAZO[1,2 A]PYRAZINE; 2 TERT BUTYL 3 BROMO 6 METHYL METHYLIMIDAZO[1,2 A]PYRAZINE; 2 TERT BUTYL 3 BROMOIMIDAZO[1,2 A]PYRAZINE; 2 TERT BUTYL 6 METHYL 2 METHYLIMIDAZO[1,2 A]PYRAZINE; 3 (3 (HYDROXYMETHYL) 6 METHYLIMIDAZO[1,2 A]PYRAZIN 2 YL) 2H CHROMEN 2 ONE; 3 (3 BROMO 6 METHYLIMIDAZO[1,2 A]PYRAZIN 2 YL) 2H CHROMEN 2 ONE; 3 (6 METHYLIMIDAZO[1,2 A]PYRAZIN 2 YL) 2H CHROMEN 2 ONE; 3 BROMO 2 (4 CHLOROPHENYL)IMIDAZO[1,2 A]PYRAZINE; 3 BROMO 2 (4 FLUOROPHENYL) 6 METHYL 2 METHYLIMIDAZO[1,2 A]PYRAZINE; 3 BROMO 2 (4 FLUOROPHENYL)IMIDAZO[1,2 A]PYRAZINE; 3 BROMO 2 PHENYLIMIDAZO[1,2 A]PYRAZINE; 3 BROMO 6 METHYL 2 PHENYLIMIDAZO[1,2 A]PYRAZINE; 3,3 (MORPHOLINOMETHYL) 2 4 TOLYLIMIDAZO[1,2 A]PYRAZINE; 6 METHYL 2 4 PHENYLIMIDAZO[1,2 A]PYRAZINE; 6 METHYL 2 PHENYL 3 [(PIPERIDIN 1 YL)METHYL]IMIDAZO[1,2 A]PYRAZINE; 6 METHYL 2 PHENYLIMIDAZO[1,2 A]PYRAZINE; 6 METHYL 2 PHENYLIMIDAZO[1,2 A]PYRAZINE 3 CARBONITRILE; [6 METHYL 2 (3 NITRO 4 PHENETHYLPHENYL]IMIDAZO[1,2 A]PYRAZIN 3 YL)METHANOL; ANTINEOPLASTIC AGENT; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CYTOTOXICITY; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIVER CARCINOMA; NEUROBLASTOMA; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; PYRAZINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957831524     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.08.035     Document Type: Article

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