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Volumn 16, Issue 17, 2006, Pages 4697-4699

Small molecule inhibitors of IgE synthesis

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E ANTIBODY;

EID: 33746233437     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.042     Document Type: Article
Times cited : (8)

References (21)
  • 9
    • 33746220690 scopus 로고    scopus 로고
    • note
    • 50 values were calculated and data normalized to an internal standard to take into account donor to donor variability. The cytotoxicity of compounds was also evaluated and shown to be unrelated to efficacy. For selected compounds, compound concentration was evaluated during the course of the experiment and was shown to remain unchanged.
  • 10
    • 33746264228 scopus 로고    scopus 로고
    • note
    • Compounds (1 μM) were incubated at 37 °C with human liver microsomes (0.5 μM) for 60 min. Concentration of compound was measured over the time course of the experiment and used to determine a disappearance half-life.
  • 11
    • 33746264227 scopus 로고    scopus 로고
    • Compounds (1 μM) were incubated at 37 °C with recombinant CYP1A1 or CYP1A2 (0.15 μM) for 60 min. Concentration of compound was measured over the time course of the experiment and used to determine a disappearance half-life.
  • 12
    • 0032414615 scopus 로고    scopus 로고
    • CYP1A1 is predominantly expressed in extra-hepatic tissues. See:
    • CYP1A1 is predominantly expressed in extra-hepatic tissues. See:. Smith G., Stubbins M.J., Harries L.W., and Wolf C.R. Xenobiotica 28 (1998) 1129
    • (1998) Xenobiotica , vol.28 , pp. 1129
    • Smith, G.1    Stubbins, M.J.2    Harries, L.W.3    Wolf, C.R.4
  • 15
    • 0141538249 scopus 로고    scopus 로고
    • For CYP1A enzymes see, for example:
    • For CYP1A enzymes see, for example:. Lewis D.F.V. Current Med. Chem. 10 (2003) 1955
    • (2003) Current Med. Chem. , vol.10 , pp. 1955
    • Lewis, D.F.V.1
  • 17
    • 33746260679 scopus 로고    scopus 로고
    • note
    • It is likely that the reduced lipophilicity of these compounds also contributes to their increased metabolic stability.
  • 18
    • 33746220642 scopus 로고    scopus 로고
    • note
    • 2O requires C, 52.15; H, 6.71; N, 22.81%.
  • 21
    • 33746220643 scopus 로고    scopus 로고
    • note
    • Despite extensive experimentation we were unable to ascertain the specific mechanism of action for these compounds.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.