New imidazo[1,2-a]pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 6, 1999, Pages 1059-1065

  Vitse, Olivier ^a   Laurent, Florence ^b   Pocock, Tristan M ^c   Bénézech, Véronique ^a   Zanik, Lahcen ^a   Elliott, Keith R F ^c   Subra, Guy ^a   Portet, Karine ^b   Bompart, Jacques ^a   Chapat, Jean Pierre ^a   Small, Roger C ^c   Michel, Alain ^b   Bonnet, Pierre Antoine ^a  

^a Laboratoire de Pharmacochimie   (France)

^b UNIV MONTPELLIER   (France)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Bronchodilation; Imidazo 1,2 a pyrazine; Phosphodiesterase inhibition; SCA 40

Indexed keywords

BRONCHODILATING AGENT; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; IMIDAZOPYRAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; GUINEA PIG; MUSCLE RELAXATION; NONHUMAN; TRACHEA;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; BRONCHODILATOR AGENTS; ENZYME INHIBITORS; GUINEA PIGS; IMIDAZOLES; PYRAZINES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRACHEA;

EID: 0033007680     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00019-X     Document Type: Article

References (27)

1. Laurent, F.; Michel, A.; Bonnet, P. A.; Chapat, J. P.; Boucard, M. Br. J. Pharmacol. 1993, 108, 622.
2. Michel, A.; Laurent, F.; Bompart, J.; Hadj-Kaddour, K.; Chapat, J. P.; Boucard, M.; Bonnet, P. A. Br. J. Pharmacol. 1993, 110, 1031.
3. Cook, S. J.; Archer, K.; Martin, A.; Buchheit, K. H.; Fozard, J. R.; Müller, T.; Miller, A. J.; Elliott, K. R. F.; Foster, R. W.; Small, R. C. Br. J. Pharmacol. 1995, 114, 143.
4. Naline, E.; Cui, Y. Y.; Michel, A.; Bonnet, P. A.; Bakdach, H.; Advenier, C. Fundam. Clin. Pharmacol. 1996, 10, 368.
5. Cortijo, J.; Villargrasa, V.; Navarette, C.; Sanz, C.; Berto, L.; Michel, A.; Bonnet, P. A.; Morcillo, E. J. Br. J. Pharmacol. 1996, 119, 99.
6. Buchheit, K. H.; Hofmann, A.; Pfannkuche, H. J. Naunyn-Schmiedeberg's Arch. Pharmacol. 1997, 355, 217.
7. Müller-Schweinitzer, E.; Fozard, J. R. Br. J. Pharmacol. 1997, 120, 1241.
8. Pocock, T.; Laurent, F.; Isaac, L. M.; Chiu, P.; Elliott, K. R. F.; Foster, R. W.; Michel, A.; Bonnet, P. A.; Small, R. C. Eur. J. Pharmacol. 1997, 334, 75.
9. Bonnet, P. A.; Michel, A.; Laurent, F.; Sablayrolles, C.; Rechencq, E.; Mani, J. C.; Boucard, M.; Chapat, J. P. J. Med. Chem. 1992, 35, 3353.
10. Basiuk, V. A. Russ. Chem. Rev. 1997, 66, 187.
11. Lumma Jr, W. C.; Randall, W. C., Cresson, E. L.; Huff, J. R.; Hartam, R. D.; Lyon, T. F. J. Med. Chem. 1983, 26, 357.
12. Meurer, L. C.; Tolman, R. L.; Chapin, E. W.; Saperstein, R.; Vicario, P. P.; Zrada, M. M.; MacCoss, M. J. Med. Chem. 1992, 35, 3845.
13. Teulade, J. C.; Bonnet, P. A.; Rieu, J. N.; Viols, H.; Chapat, J. P.; Grassy, G.; Carpy, A. J. Chem. Res. (M) 1986, 202.
14. Vitse, O.; Bonnet, P. A.; Bompart, J.; Viols, H.; Subra, G.; Chapat, J. P.; Grassy, G. J. Heterocyclic Chem. 1997, 34, 701.
15. Arriau, J.; Chalvet, O.; Dargelos, A.; Maury, G. J. Heterocyclic Chem. 1974, 11, 1013.
16. Laurent, F.; Michel, A.; Bonnet, P. A., Bompart, J.; Chapat, J. P., Boucard, M. C. R. Soc. Biol. 1993, 187, 526.
17. Giangiacomo, M. M.; Garcia, M. L.; McManus, O. B. Biochemistry 1992, 31, 6719.
18. MacMillan, S.; Sheridan, R. D.; Chilvers, E. R.; Patmore, L. Br. J. Pharmacol. 1993, 116, 1656.
19. Fagni, L. et al. unpublished results.
20. Harris, A. L.; Connell, M . J.; Ferguson, E. W.; Wallace, A. M.; Gordon, R. J.; Pagani, E. D.; Silver, P. J. J. Pharmacol. Exp. Ther. 1989, 251, 199.
21. Berry, J. L.; Elliott, K. R. F.; Foster, R. W.; Small, R. C. Br. J. Pharmacol. 1991, 104, 206P.
22. Sablayrolles, C.; Cros, G.; Milhavet, J. C.; Rechencq, E.; Chapat, J. P.; Boucard, M.; Serrano, J. J.; McNeill, J. H. J. Med. Chem. 1984, 27, 206.
23. Castro, C. E., US Patent, 3,259,641, 1966.
24. Hooker, C. S.; Calkins, P. Y.; Fleish, J. H. Blood Vessels 1971, 14, 1.
25. Elliott, K. R. F.; Berry, J. L.; Bate, A. J.; Foster, R. W.; Small, R. C. J. Enzyme Inhibition 1991, 4, 245.
26. Thompson, W. J.; Appleman, M. M. Biochemistry 1971, 10, 311.
27. Rutten, B. M.; Schoot, W. J.; Depont, J. J. Biochem. Biophys. Acta. 1973, 315, 378.