Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4448-4458

  Linz, Sabine ^a   Müller, Jörg ^a   Hübner, Harald ^a   Gmeiner, Peter ^a   Troschütz, Reinhard ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

D4 receptor; Dopamine; Heterocyclic compounds; Mannich bases

Indexed keywords

7 (DIMETHYLAMINO)METHYL 3 METHYL 2 PYRROLIDIN 1 YL 4,5 DIHYDRO 4H PYRROLO[3,2 D]PYRIMIDIN 4 ONE; AROMATIC COMPOUND; BENZENE DERIVATIVE; CLOZAPINE; DOPAMINE 4 RECEPTOR; HETEROCYCLIC COMPOUND; IMIDAZOLE DERIVATIVE; MANNICH BASE; METHYL GROUP; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; CATTLE; CHO CELLS; CLOZAPINE; CRICETINAE; CRICETULUS; HUMANS; MOLECULAR STRUCTURE; PIPERAZINES; PROTEIN BINDING; PYRIMIDINES; RECEPTORS, DOPAMINE; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66449091877     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.015     Document Type: Article

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