The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke

Neurochemical Research

Volumn 35, Issue 9, 2010, Pages 1315-1322

  Brouns, Raf ^a,b,c   Verkerk, Robert ^b   Aerts, Tony ^b   De Surgeloose, Didier ^c   Wauters, Annick ^c   Scharpé, Simon ^b   De Deyn, Peter P ^b,c  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c MIDDELHEIM HOSPITAL   (Belgium)

Author keywords

3 Hydroxykynurenine; Acute cerebral infarction; Kynurenic acid; Kynurenine Tryptophan

Indexed keywords

3 HYDROXYANTHRANILIC ACID; C REACTIVE PROTEIN; KYNURENIC ACID; KYNURENINE; TRYPTOPHAN;

ACUTE BRAIN DISEASE; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CORRELATION FUNCTION; DISEASE SEVERITY; ENCEPHALITIS; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HOSPITAL ADMISSION; HUMAN; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; PRIORITY JOURNAL; PROTEIN FUNCTION; TRYPTOPHAN METABOLISM;

3-HYDROXYANTHRANILIC ACID; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; FREE RADICAL SCAVENGERS; HUMANS; INFLAMMATION; KYNURENINE; MALE; STROKE; TRYPTOPHAN;

EID: 77957830542     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-010-0187-2     Document Type: Article

References (38)

1. Brouns R, de Deyn PP (2009) The complexity of neurobiological processes in acute ischemic stroke. Clin Neurol Neurosurg 111:483-495
2. Croonenberghs J, Spaas K, Wauters A et al (2008) Faulty sero-tonin-DHEA interactions in autism: results of the 5-hydroxytry-ptophan challenge test. Neuro Endocrinol Lett 29:385-390
3. Myint AM, Kim YK, Verkerk R et al (2007) Tryptophan breakdown pathway in bipolar mania. J Affect Disord 102:65-72 (Pubitemid 47042175)
4. Van Gool AR, Verkerk R, Fekkes D et al (2008) Neurotoxic and neuroprotective metabolites of kynurenine in patients with renal cell carcinoma treated with interferon-alpha: course and relationship with psychiatric status. Psychiatry Clin Neurosci 62:597-602
5. Wichers MC, Koek GH, Robaeys G et al (2005) IDO and inter-feron-alpha- induced depressive symptoms: A shift in hypothesis from tryptophan depletion to neurotoxicity. Mol Psychiatry 10:538-544 (Pubitemid 40897037)
6. Bonaccorso S, Marino V, Puzella A et al (2002) Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system. J Clin Psychopharmacol 22:86-90 (Pubitemid 34101297)
7. Song C, Lin A, Bonaccorso S et al (1998) The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression. J Affect Disord 49:211-219 (Pubitemid 28218842)
8. Maes M, Verkerk R, Vandoolaeghe E et al (1997) Serotonin-immune interactions in major depression: lower serum tryptophan as A marker of an immune-inflammatory response. Eur Arch Psychiatry Clin Neurosci 247:154-161 (Pubitemid 27257585)
9. Myint AM, Kim YK, Verkerk R et al (2007) Kynurenine pathway in major depression: evidence of impaired neuroprotection. J Affect Disord 98:143-151 (Pubitemid 46048912)
10. Stone TW, Mackay GM, Forrest CM et al (2003) Tryptophan metabolites and brain disorders. Clin Chem Lab Med 41:852-859
11. Taguchi A, Hara A, Saito K et al (2008) Localization and spatiotemporal expression of IDO following transient forebrain ischemia in gerbils. Brain Res 1217:78-85
12. Cozzi A, Carpenedo R, Moroni F (1999) Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitro-benzoyl)-alanine (mNBA) and 3, 4-dimethoxy-[-N-4-(nitro-phenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia. J Cereb Blood Flow Metab 19:771-777 (Pubitemid 30159803)
13. Darlington LG, Mackay GM, Forrest CM et al (2007) Altered kynurenine metabolism correlates with infarct volume in stroke. Eur J Neurosci 26:2211-2221
14. Bender DA, McCreanor GM (1985) Kynurenine hydroxylase: A potential rate-limiting enzyme in tryptophan metabolism. Biochem Soc Trans 13:441-143
15. Alberati-Giani D, Cesura AM (1998) Expression of the kynurenine enzymes in macrophages and microglial cells: regulation by immune modulators. Amino Acids 14:251-255 (Pubitemid 28051180)
16. Swartz KJ, During MJ, Freese A, Beal MF (1990) Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors. J Neurosci 10:2965-2973
17. Okuda S, Nishiyama N, Saito H, Katsuki H (1998) 3-Hydroxy-kynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem 70:299-307 (Pubitemid 28020856)
18. Stone TW, Perkins MN (1981) Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol 72:411-112
19. Taylor MW, Feng GS (1991) Relationship between interferon-gamma, indoleamine 2, 3-dioxygenase, and tryptophan catabo-lism. FASEB J 5:2516-2522
20. Fukui S, Schwarcz R, Rapoport SI et al (1991) Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem 56:2007-2017
21. Brouns R, Sheorajpanday R, Wauters A et al (2008) Evaluation of lactate as A marker of metabolic stress and cause of secondary damage in acute ischemic stroke or TIA. Clin Chim Acta 397: 27-31
22. Brouns R, Heylen E, Sheorajpanday R et al (2009) Carboxy-peptidase U (TAFIa) decreases the efficacy of thrombolytic therapy in ischemic stroke patients. Clin Neurol Neurosurg 111:165-170
23. Brouns R, Sheorajpanday R, Kunnen J et al (2009) Clinical, biochemical and neuroimaging parameters after thrombolytic therapy predict long-term stroke outcome. Eur Neurol 62:9-15
24. Brouns R, Marescau B, Possemiers I et al (2009) Dimethylargi-nine levels in cerebrospinal fluid of hyperacute ischemic stroke patients are associated with stroke severity. Neurochem Res 34:1642-1649
25. Brouns R, Van Den Bossche J, de Surgeloose D et al (2009) Clinical and biochemical diagnosis of small-vessel disease in acute ischemic stroke. J Neurol Sci 285:185-190
26. Brouns R, Heylen E, Willemse JL et al (2010) The decrease in procarboxypeptidase U (TAFI) concentration in acute ischemic stroke correlates with stroke severity, evolution and outcome. J Thromb Haemost 8:75-80
27. Schroecksnadel K, Fiegl M, Prassl K et al (2007) Diminished quality of life in patients with cancer correlates with tryptophan degradation. J Cancer Res Clin Oncol 133:477-485 (Pubitemid 46800668)
28. Pawlak K, Brzosko S, Mysliwiec M, Pawlak D (2009) Kynurenine, quinolinic acid-The new factors linked to carotid atherosclerosis in patients with end-stage renal disease. Atherosclerosis 204:561-566
29. Logters TT, Laryea MD, Altrichter J et al. (2008) Increased plasma kynurenine values and kynurenine: tryptophan ratios after major trauma are early indicators for the development of sepsis. Shock (in press)
30. Heyes MP, Saito K, Devinsky O, Nadi NS (1994) Kynurenine pathway metabolites in cerebrospinal fluid and serum in complex partial seizures. Epilepsia 35:251-257 (Pubitemid 24138806)
31. Sulter G, Steen C, de Keyser J (1999) Use of the Barthel index and modified Rankin scale in acute stroke trials. Stroke 30:1538-1541 (Pubitemid 29379599)
32. Dziedzic T (2008) Clinical significance of acute phase reaction in stroke patients. Front Biosci 13:2922-2927 (Pubitemid 351589209)
33. Forrest CM, Mackay GM, Stoy N et al (2004) Tryptophan loading induces oxidative stress. Free Radic Res 38:1167-1171 (Pubitemid 39654505)
34. Herve C, Beyne P, Jamault H, Delacoux E (1996) Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection. J Chromatogr B Biomed Appl 675:157-161 (Pubitemid 26036980)
35. Pawlak D, Pawlak K, Malyszko J et al (2001) Accumulation of toxic products degradation of kynurenine in hemodialyzed patients. Int Urol Nephrol 33:399-404 (Pubitemid 34575400)
36. Mackay GM, Forrest CM, Stoy N et al (2006) Tryptophan metabolism and oxidative stress in patients with chronic brain injury. Eur J Neurol 13:30-42
37. McMillan DC (2009) Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 12:223-226
38. Stone TW, Darlington LG (2002) Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Dis-cov 1:609-620 (Pubitemid 37361524)