메뉴 건너뛰기




Volumn 24, Issue 1-2, 2010, Pages 79-83

Galleria mellonella larvae as models for studying fungal virulence

Author keywords

Alternative models; Aspergillus; Candida; Fungi; Galleria mellonella; In vivo testing; Mini hosts

Indexed keywords

ASPERGILLUS; CANDIDA; FUNGI; GALLERIA MELLONELLA; HEXAPODA; MAMMALIA;

EID: 77957814233     PISSN: 17494613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fbr.2010.04.001     Document Type: Review
Times cited : (61)

References (45)
  • 1
    • 21744431524 scopus 로고    scopus 로고
    • In vitro and in vivo susceptibility of the honey bee pathogen Paenibacillus larvae to the antibiotic tylosin
    • Alippi A.M., et al. In vitro and in vivo susceptibility of the honey bee pathogen Paenibacillus larvae to the antibiotic tylosin. Vet. Microbiol. 2005, 109:47-55.
    • (2005) Vet. Microbiol. , vol.109 , pp. 47-55
    • Alippi, A.M.1
  • 2
    • 0345096508 scopus 로고    scopus 로고
    • Fluctuations in haemocyte density and microbial load may be used as indicators of fungal pathogenicity in larvae of Galleria mellonella
    • Bergin D., et al. Fluctuations in haemocyte density and microbial load may be used as indicators of fungal pathogenicity in larvae of Galleria mellonella. Microbes Infect. 2003, 5:1389-1395.
    • (2003) Microbes Infect. , vol.5 , pp. 1389-1395
    • Bergin, D.1
  • 3
    • 21544481993 scopus 로고    scopus 로고
    • Superoxide production in haemocytes of Galleria mellonella - identification of proteins homologous to the NADPH oxidase complex of human neutrophils
    • Bergin D., et al. Superoxide production in haemocytes of Galleria mellonella - identification of proteins homologous to the NADPH oxidase complex of human neutrophils. Infect. Immun. 2005, 73:4161-4173.
    • (2005) Infect. Immun. , vol.73 , pp. 4161-4173
    • Bergin, D.1
  • 4
    • 33748145106 scopus 로고    scopus 로고
    • Pre-exposure to yeast protects larvae of Galleria mellonella from a subsequent lethal infection by Candida albicans and is mediated by the increased expression of antimicrobial peptides
    • Bergin D., et al. Pre-exposure to yeast protects larvae of Galleria mellonella from a subsequent lethal infection by Candida albicans and is mediated by the increased expression of antimicrobial peptides. Microb. Infect. 2006, 8:2105-2112.
    • (2006) Microb. Infect. , vol.8 , pp. 2105-2112
    • Bergin, D.1
  • 5
    • 0037063976 scopus 로고    scopus 로고
    • Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae
    • Brennan M., et al. Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae. FEMS Immunol. Med. Microbiol. 2002, 34:153-157.
    • (2002) FEMS Immunol. Med. Microbiol. , vol.34 , pp. 153-157
    • Brennan, M.1
  • 6
    • 0033983382 scopus 로고    scopus 로고
    • Development of an insect model for the in vivo pathogenicity testing of yeasts
    • Cotter G., et al. Development of an insect model for the in vivo pathogenicity testing of yeasts. FEMS Immunol. Med. Microbiol. 2000, 27:163-169.
    • (2000) FEMS Immunol. Med. Microbiol. , vol.27 , pp. 163-169
    • Cotter, G.1
  • 7
    • 62449104891 scopus 로고    scopus 로고
    • Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
    • Cowen L.E., et al. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2818-2823.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 2818-2823
    • Cowen, L.E.1
  • 8
    • 38249042189 scopus 로고
    • Pathogenicity of lipopolysaccharide mutants of Pseudomonas aeruginosa for larvae of Galleria mellonella
    • Dunphy G., et al. Pathogenicity of lipopolysaccharide mutants of Pseudomonas aeruginosa for larvae of Galleria mellonella. J. Invertebr. Pathol. 1986, 47:48-55.
    • (1986) J. Invertebr. Pathol. , vol.47 , pp. 48-55
    • Dunphy, G.1
  • 9
    • 0000080299 scopus 로고
    • Interaction of surface modified subspecies of Xenorhabdus nematophilus with the hemolymph and hemocytes of larval Galleria mellonella
    • Dunphy G., Webster J. Interaction of surface modified subspecies of Xenorhabdus nematophilus with the hemolymph and hemocytes of larval Galleria mellonella. J. Insect Physiol. 1984, 30:883-889.
    • (1984) J. Insect Physiol. , vol.30 , pp. 883-889
    • Dunphy, G.1    Webster, J.2
  • 10
    • 0345096422 scopus 로고    scopus 로고
    • Virulence of Candida albicans mutants toward larval Galleria mellonella (Insecta, Lepidoptera, Galleridae)
    • Dunphy G.B., et al. Virulence of Candida albicans mutants toward larval Galleria mellonella (Insecta, Lepidoptera, Galleridae). Can. J. Microbiol. 2003, 49:514-524.
    • (2003) Can. J. Microbiol. , vol.49 , pp. 514-524
    • Dunphy, G.B.1
  • 11
    • 34447272054 scopus 로고    scopus 로고
    • Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans
    • Fan W., et al. Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans. Infect. Immun. 2007, 75(7):3394-3405.
    • (2007) Infect. Immun. , vol.75 , Issue.7 , pp. 3394-3405
    • Fan, W.1
  • 12
    • 2342599737 scopus 로고    scopus 로고
    • Comparative analysis of the production of insecticidal and melanizing macromolecules by strains of Beauveria spp.: in vivo studies
    • Fuguet R., Vey A. Comparative analysis of the production of insecticidal and melanizing macromolecules by strains of Beauveria spp.: in vivo studies. J. Invert. Pathol. 2004, 85:152-167.
    • (2004) J. Invert. Pathol. , vol.85 , pp. 152-167
    • Fuguet, R.1    Vey, A.2
  • 13
    • 33746287716 scopus 로고    scopus 로고
    • Using non-mammalian host to study fungal virulence and host defense
    • Fuchs B., Mylonakis E. Using non-mammalian host to study fungal virulence and host defense. Curr. Opin. Microbiol. 2006, 9:346-351.
    • (2006) Curr. Opin. Microbiol. , vol.9 , pp. 346-351
    • Fuchs, B.1    Mylonakis, E.2
  • 14
    • 0031280505 scopus 로고    scopus 로고
    • Effects of the entomopathogenic fungus Metarhizium anisopliae and its secondary metabolites on morphology and cytoskeleton of plasmatocytes isolated from the greater wax moth, Galleria mellonella
    • Gotz P., et al. Effects of the entomopathogenic fungus Metarhizium anisopliae and its secondary metabolites on morphology and cytoskeleton of plasmatocytes isolated from the greater wax moth, Galleria mellonella. J. Insect. Physiol. 1997, 43:1149-1159.
    • (1997) J. Insect. Physiol. , vol.43 , pp. 1149-1159
    • Gotz, P.1
  • 15
    • 1442275726 scopus 로고    scopus 로고
    • Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms
    • Hamamoto H., et al. Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms. Antimicrob. Agents Chemother. 2004, 48:774-779.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 774-779
    • Hamamoto, H.1
  • 16
    • 60649088439 scopus 로고    scopus 로고
    • Silkworm as a model animal to evaluate drug candidate toxicity and metabolism
    • Hamamoto H., et al. Silkworm as a model animal to evaluate drug candidate toxicity and metabolism. Comp. Biochem. Physiol. 2009, 149:334-339.
    • (2009) Comp. Biochem. Physiol. , vol.149 , pp. 334-339
    • Hamamoto, H.1
  • 17
    • 64149120666 scopus 로고    scopus 로고
    • Assessment of virulence of colour mutants of A. fumigatus
    • Jackson J.C., et al. Assessment of virulence of colour mutants of A. fumigatus. PLoS ONE 2009, 4(1):4224.
    • (2009) PLoS ONE , vol.4 , Issue.1 , pp. 4224
    • Jackson, J.C.1
  • 18
    • 38849138675 scopus 로고    scopus 로고
    • New insect system for testing antibiotics
    • Johny S., et al. New insect system for testing antibiotics. J. Parasitol. 2007, 93:1505-1511.
    • (2007) J. Parasitol. , vol.93 , pp. 1505-1511
    • Johny, S.1
  • 19
    • 1242351240 scopus 로고    scopus 로고
    • Exploiting the potential of Insects for in vivo pathogenicity testing of microbial pathogens
    • Kavanagh K., Reeves E.P. Exploiting the potential of Insects for in vivo pathogenicity testing of microbial pathogens. FEMS Microbiol. Rev. 2004, 28:101-112.
    • (2004) FEMS Microbiol. Rev. , vol.28 , pp. 101-112
    • Kavanagh, K.1    Reeves, E.P.2
  • 20
    • 0036784566 scopus 로고    scopus 로고
    • Insect haemocytes and their role in immunity
    • Lavine M.D., Strand M.R. Insect haemocytes and their role in immunity. Insect. Biochem. Mol. Biol. 2002, 32:1295-1309.
    • (2002) Insect. Biochem. Mol. Biol. , vol.32 , pp. 1295-1309
    • Lavine, M.D.1    Strand, M.R.2
  • 21
    • 0034917348 scopus 로고    scopus 로고
    • The importance of the innate immune system in controlling HIV infection and disease
    • Levy J.A. The importance of the innate immune system in controlling HIV infection and disease. Trends Immunol. 2001, 22:312-316.
    • (2001) Trends Immunol. , vol.22 , pp. 312-316
    • Levy, J.A.1
  • 22
    • 15544363784 scopus 로고    scopus 로고
    • Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence
    • Lionakis M.S., et al. Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence. J. Infect. Dis. 2005, 191:1188-1195.
    • (2005) J. Infect. Dis. , vol.191 , pp. 1188-1195
    • Lionakis, M.S.1
  • 23
    • 22844431721 scopus 로고    scopus 로고
    • Fruit flies as a mini-host model for studying drug activity and virulence in Aspergillus
    • Lionakis M.S., Kontoyiannis D.P. Fruit flies as a mini-host model for studying drug activity and virulence in Aspergillus. Med. Mycol. 2005, 43:111-114.
    • (2005) Med. Mycol. , vol.43 , pp. 111-114
    • Lionakis, M.S.1    Kontoyiannis, D.P.2
  • 24
    • 33646545663 scopus 로고    scopus 로고
    • The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host-pathogen interactions
    • London R., et al. The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host-pathogen interactions. FEMS Yeast. Res. 2006, 6:567-573.
    • (2006) FEMS Yeast. Res. , vol.6 , pp. 567-573
    • London, R.1
  • 25
    • 0342287233 scopus 로고
    • Changes in haemocyte counts in Galleria mellonella (L) (Lepidoptera: Galleriidae) larvae infected with Steinernema sp. (Nematoda: steinernematidae)
    • Matha V., Mracek Z. Changes in haemocyte counts in Galleria mellonella (L) (Lepidoptera: Galleriidae) larvae infected with Steinernema sp. (Nematoda: steinernematidae). Nematology 1984, 30:86-89.
    • (1984) Nematology , vol.30 , pp. 86-89
    • Matha, V.1    Mracek, Z.2
  • 26
    • 0023181606 scopus 로고
    • Reactions of hemocytes of immune and non-immune Galleria mellonella
    • Morton D.B., et al. Reactions of hemocytes of immune and non-immune Galleria mellonella. Dev. Comp. Immunol. 1987, 11:47-55.
    • (1987) Dev. Comp. Immunol. , vol.11 , pp. 47-55
    • Morton, D.B.1
  • 27
    • 38549110765 scopus 로고    scopus 로고
    • Effect of pre-incubation temperature on susceptibility of Galleria mellonella to infection by Candida albicans
    • Mowlds P., Kavanagh K. Effect of pre-incubation temperature on susceptibility of Galleria mellonella to infection by Candida albicans. Mycopathologia 2008, 165:5-12.
    • (2008) Mycopathologia , vol.165 , pp. 5-12
    • Mowlds, P.1    Kavanagh, K.2
  • 28
    • 44449155195 scopus 로고    scopus 로고
    • Physical stress primes the immune response of Galleria mellonella larvae to infection by Candida albicans
    • Mowlds P., et al. Physical stress primes the immune response of Galleria mellonella larvae to infection by Candida albicans. Microbes Infect 2008, 10:628-634.
    • (2008) Microbes Infect , vol.10 , pp. 628-634
    • Mowlds, P.1
  • 29
    • 21544465310 scopus 로고    scopus 로고
    • Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis
    • Mylonakis E., et al. Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect. Immun. 2005, 73(7):3842-3850.
    • (2005) Infect. Immun. , vol.73 , Issue.7 , pp. 3842-3850
    • Mylonakis, E.1
  • 30
    • 38549111944 scopus 로고    scopus 로고
    • Galleria mellonella and the study of fungal pathogenesis: making the case for another genetically tractable model host
    • Mylonakis E. Galleria mellonella and the study of fungal pathogenesis: making the case for another genetically tractable model host. Mycopathologia 2008, 165:1-3.
    • (2008) Mycopathologia , vol.165 , pp. 1-3
    • Mylonakis, E.1
  • 31
    • 0022255535 scopus 로고
    • Invertebrate immunity - a primer for the non-specialist
    • Ratcliffe N. Invertebrate immunity - a primer for the non-specialist. Immunol. Lett. 1985, 10:253-270.
    • (1985) Immunol. Lett. , vol.10 , pp. 253-270
    • Ratcliffe, N.1
  • 32
    • 4444297435 scopus 로고    scopus 로고
    • Correlation of gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella
    • Reeves E.P., et al. Correlation of gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella. Mycopathologia 2004, 158:73-79.
    • (2004) Mycopathologia , vol.158 , pp. 73-79
    • Reeves, E.P.1
  • 33
    • 33745212690 scopus 로고    scopus 로고
    • A nonribosomal peptide synthetase (pes1) confers protection against oxidative stress in Aspergillus fumigatus
    • Reeves E.P., et al. A nonribosomal peptide synthetase (pes1) confers protection against oxidative stress in Aspergillus fumigatus. FEBS J. 2006, 273:3038-3053.
    • (2006) FEBS J. , vol.273 , pp. 3038-3053
    • Reeves, E.P.1
  • 34
    • 33745020068 scopus 로고    scopus 로고
    • Susceptibility of larvae of Galleria mellonella to infection by Aspergillus fumigatus is dependent upon stage of conidial germination
    • Renwick J., et al. Susceptibility of larvae of Galleria mellonella to infection by Aspergillus fumigatus is dependent upon stage of conidial germination. Mycopathologia 2006, 161:377-384.
    • (2006) Mycopathologia , vol.161 , pp. 377-384
    • Renwick, J.1
  • 35
    • 33845575834 scopus 로고    scopus 로고
    • Translocation of proteins homologous to human neutrophil p47phox and p67phox to the cell membrane in activated hemocytes of Galleria mellonella
    • Renwick J., et al. Translocation of proteins homologous to human neutrophil p47phox and p67phox to the cell membrane in activated hemocytes of Galleria mellonella. Dev. Comp. Immunol. 2007, 31:347-359.
    • (2007) Dev. Comp. Immunol. , vol.31 , pp. 347-359
    • Renwick, J.1
  • 36
    • 0031905311 scopus 로고    scopus 로고
    • A family of human receptors structurally related to Drosophila
    • Rock F.L., et al. A family of human receptors structurally related to Drosophila. Dev. Biol. 1998, 95:588-593.
    • (1998) Dev. Biol. , vol.95 , pp. 588-593
    • Rock, F.L.1
  • 37
    • 0033179414 scopus 로고    scopus 로고
    • Immunity to Candida albicans: Th1, Th2 cells and beyond
    • Romani L. Immunity to Candida albicans: Th1, Th2 cells and beyond. Curr. Opin. Microbiol. 1999, 2:363-367.
    • (1999) Curr. Opin. Microbiol. , vol.2 , pp. 363-367
    • Romani, L.1
  • 38
    • 67349115960 scopus 로고    scopus 로고
    • Use of Galleria mellonella larvae to evaluate the in vivo anti-fungal activity of [Ag2(mal)(phen)3]
    • Rowan R., et al. Use of Galleria mellonella larvae to evaluate the in vivo anti-fungal activity of [Ag2(mal)(phen)3]. Biometals 2009, 22:461-467.
    • (2009) Biometals , vol.22 , pp. 461-467
    • Rowan, R.1
  • 39
    • 33748517279 scopus 로고    scopus 로고
    • The host acts as a genetic bottleneck during serial infections: an insect-fungal model system
    • Scully L.R., Bidochka M.J. The host acts as a genetic bottleneck during serial infections: an insect-fungal model system. Curr. Genet. 2006, 50:335-345.
    • (2006) Curr. Genet. , vol.50 , pp. 335-345
    • Scully, L.R.1    Bidochka, M.J.2
  • 40
    • 0036792555 scopus 로고    scopus 로고
    • Drosophila melanogaster as a model system for drug discovery and pathway screening
    • Tickoo S., Russell S. Drosophila melanogaster as a model system for drug discovery and pathway screening. Curr. Opin. Pharmacol. 2002, 2:555-560.
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 555-560
    • Tickoo, S.1    Russell, S.2
  • 41
    • 70349428436 scopus 로고    scopus 로고
    • Spores as infectious propagules of Cryptococcus neoformans
    • Vegapuldi R., et al. Spores as infectious propagules of Cryptococcus neoformans. Infect. Immun. 2009, 77:4345-4355.
    • (2009) Infect. Immun. , vol.77 , pp. 4345-4355
    • Vegapuldi, R.1
  • 42
    • 33847112385 scopus 로고    scopus 로고
    • Isolation, activity and immunological characterisation of a secreted aspartic protease, CtsD, from Aspergillus fumigatus
    • Vickers I., et al. Isolation, activity and immunological characterisation of a secreted aspartic protease, CtsD, from Aspergillus fumigatus. Protein Expr. Purif. 2007, 53:216-224.
    • (2007) Protein Expr. Purif. , vol.53 , pp. 216-224
    • Vickers, I.1
  • 43
    • 67349227161 scopus 로고    scopus 로고
    • Humoral immune response of Galleria mellonella larvae after infection by Beauveria bassiana under optimal and heat-shock conditions
    • Wodja I., et al. Humoral immune response of Galleria mellonella larvae after infection by Beauveria bassiana under optimal and heat-shock conditions. J. Insect. Physiol. 2009, 55:525-531.
    • (2009) J. Insect. Physiol. , vol.55 , pp. 525-531
    • Wodja, I.1
  • 44
    • 0032819255 scopus 로고    scopus 로고
    • Presence of IL-1 and TNF like molecules in Galleria mellonella (Lepidoptera) haemocytes and in an insect cell line from Estimene acraea (Lepidoptera)
    • Wittwer D., et al. Presence of IL-1 and TNF like molecules in Galleria mellonella (Lepidoptera) haemocytes and in an insect cell line from Estimene acraea (Lepidoptera). Cytokine 1999, 11:637-642.
    • (1999) Cytokine , vol.11 , pp. 637-642
    • Wittwer, D.1
  • 45
    • 0001996555 scopus 로고    scopus 로고
    • In search of a function for hemolin, a haemolymph protein from the immunoglobulin superfamily
    • Zhao L., Kanost M.R. In search of a function for hemolin, a haemolymph protein from the immunoglobulin superfamily. J. Insect. Physiol. 1996, 42:73-77.
    • (1996) J. Insect. Physiol. , vol.42 , pp. 73-77
    • Zhao, L.1    Kanost, M.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.