Neuroprotective effects of gabapentin in experimental spinal cord injury

World Neurosurgery

Volumn 73, Issue 6, 2010, Pages 729-734

  Emmez, Hakan ^a   Börcek, Alp Özgn ^a   Kaymaz, Memduh ^a   Kaymaz, Figen ^b   Durda, Emre ^a   Ivi, Soner ^a   Glbahar, Çzlem ^a   Aykol, Ökr ^a   Paaolu, Aydn ^a  

^a GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Gabapentin; Neuroprotection; Spinal cord injury

Indexed keywords

GABAPENTIN; METHYLPREDNISOLONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; AMINE; AMINO ACID RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLIP; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; LAMINECTOMY; LIPID PEROXIDATION; LOW DRUG DOSE; MALE; NEUROPROTECTION; NONHUMAN; RAT; SPINAL CORD INJURY; TREATMENT OUTCOME; WISTAR RAT; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SPINAL CORD INJURIES;

AMINES; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; MALE; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SPINAL CORD INJURIES; TREATMENT OUTCOME;

EID: 77957809942     PISSN: 18788750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.wneu.2010.04.008     Document Type: Review

References (44)

1. N.L. Banik, E.L. Hogan, J.M. Powers, and L.J. Whetstine Degradation of cytoskeletal proteins in experimental spinal cord injury Neurochem Res 7 1982 1465 1475
2. N.L. Banik, J.M. Powers, and E.L. Hogan The effects of spinal cord trauma on myelin J Neuropathol Exp Neurol 39 1980 232 244
3. M.B. Bracken Steroids for acute spinal cord injury Cochrane Database Syst Rev 3 2002 CD001046
4. M.B. Bracken, M.J. Shepard, W.F. Collins Jr, T.R. Holford, D.S. Baskin, H.M. Eisenberg, E. Flamm, L. Leo-Summers, J.C. Maroon, L.F. Marshall, P.L. Perot, J. Piepmeier, V.K.H. Sonntag, F.C. Wegner, J.L. Wilberger, R. Winn, and W. Young Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data Results of the second National Acute Spinal Cord Injury Study J Neurosurg 76 1992 23 31
5. M.B. Bracken, M.J. Shepard, T.R. Holford, L. Leo-Summers, E.F. Aldrich, M. Fazl, M.G. Fehlings, D.L. Herr, P.W. Hitchon, L.F. Marshall, R.P. Nockels, V. Pascale, P.L. Perot Jr, J. Piepmeier, V.K. Sonntag, F. Wagner, J.E. Wilberger, H.R. Winn, and W. Young Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up Results of the third National Acute Spinal Cord Injury randomized controlled trial J Neurosurg 89 1998 699 706
6. G.D. Carlson, and C. Gorden Current developments in spinal cord injury research Spine J 2 2002 116 128
7. J.K. Cheng, and L.C. Chiou Mechanisms of the antinociceptive action of gabapentin J Pharmacol Sci 100 2006 471 486
8. B.A. Chizh, M. Scheede, and H. Schlutz Antinociception and (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid antagonism by gabapentin in the rat spinal cord in vivo Naunyn Schmiedebergs Arch Pharmacol 362 2000 197 200
9. T.J. Coderre, N. Kumar, C.D. Lefebvre, and J.S. Yu Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate J Neurochem 94 2005 1131 1139
10. A.I. Faden, and R.P. Simon A potential role for excitotoxins in the pathophysiology of spinal cord injury Ann Neurol 23 1988 623 626
11. M.G. Fehlings, C.H. Tator, and R.D. Linden The relationships among the severity of spinal cord injury, motor and somatosensory evoked potentials and spinal cord blood flow Electroencephalography and Clinical Neurophysiology 74 1989 241 259
12. K. Fink, W. Meder, D.J. Dooley, and M. Gothert Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices Br J Pharmacol 130 2000 900 906
13. D. Gerard-Monnier, I. Erdelmeier, K. Regnard, N. Moze-Henry, J.C. Yadan, and J. Chaudiere Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals Analytical applications to a colorimetric assay of lipid peroxidation Chem Res Toxicol 11 1998 1176 1183 (Pubitemid 28500798)
14. A. Goldlust, T.Z. Su, D.F. Welty, C.P. Taylor, and D.L. Oxender Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA Epilepsy Res 22 1995 1 11
15. E.D. Hall, and J.M. Braughler Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and Na+ + K+)-ATPase activity Dose-response analysis during 1st hour after contusion injury in the cat J Neurosurg 57 1982 247 253
16. E.D. Hall, and J.M. Braughler Free radicals in CNS injury Res Publ Assoc Res Nerv Ment Dis 71 1993 81 105
17. E.D. Hall, and J.E. Springer Neuroprotection and acute spinal cord injury: a reappraisal NeuroRx 1 2004 80 100
18. A. Holtz, B. Nystrom, B. Gerdin, and Y. Olsson Neuropathological changes and neurological function after spinal cord compression in the rat J Neurotrauma 7 1990 155 167 (Pubitemid 20371634)
19. F. Ildan, S. Polat, A. Oner, T. Isbir, A.I. Gocer, O. Tap, M. Kaya, and A. Karadayi Effects of naloxone on sodium- and potassium-activated and magnesium-dependent adenosine-5'-triphosphatase activity and lipid peroxidation and early ultrastructural findings after experimental spinal cord injury Neurosurgery 36 1995 797 805
20. S. Kahraman, B. Duz, H. Kayali, A. Korkmaz, S. Oter, A. Aydin, and A. Sayal Effects of methylprednisolone and hyperbaric oxygen on oxidative status after experimental spinal cord injury: a comparative study in rats Neurochem Res 32 2007 1547 1551
21. M. Kalayci, O. Coskun, F. Cagavi, M. Kanter, F. Armutcu, S. Gul, and B. Acikgoz Neuroprotective effects of ebselen on experimental spinal cord injury in rats Neurochem Res 30 2005 403 410
22. E. Kaptanolu, E. Beskonakli, I. Solaroglu, A. Kilinc, and Y. Taskin Magnesium sulfate treatment in experimental spinal cord injury: emphasis on vascular changes and early clinical results Neurosurg Rev 26 2003 283 287 (Pubitemid 37248224)
23. E. Kaptanolu, H.H. Caner, H.S. Surucu, and F. Akbiyik Effect of mexiletine on lipid peroxidation and early ultrastructural findings in experimental spinal cord injury J Neurosurg 91 Suppl 1999 200 204
24. E. Kaptanolu, S. Palaoglu, H.S. Surucu, M. Hayran, and E. Beskonakli Ultrastructural scoring of graded acute spinal cord injury in the rat J Neurosurg Spine 97 2002 49 56
25. E. Kaptanolu, I. Solaroglu, O. Okutan, H.S. Surucu, F. Akbiyik, and E. Beskonakli Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: effect on lipid peroxidation and early ultrastructural findings Neurosurg Rev 27 2004 113 120
26. E. Kaptanolu, M. Tuncel, S. Palaoglu, A. Konan, E. Demirpence, and K. Kilinc Comparison of the effects of melatonin and methylprednisolone in experimental spinal cord injury J Neurosurg 93 Suppl 2000 77 84
27. W. Lagrze, R. Mller-Velten, and T. Feuerstein The neuroprotective properties of gabapentin-lactam Graefe's Archive for Clinical and Experimental Ophthalmology 239 2001 845 849
28. M.J. McLean, and B.E. Gidal Gabapentin dosing in the treatment of epilepsy Clin Ther 25 2003 1382 1406
29. G.Y. Ng, S. Bertrand, R. Sullivan, N. Ethier, J. Wang, J. Yergey, M. Belley, L. Trimble, K. Bateman, L. Alder, A. Smith, R. McKernan, K. Metters, G.P. O'Neill, J.C. Lacaille, and T.E. Hebert Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action Mol Pharmacol 59 2001 144 152
30. O. Okutan, I. Solaroglu, E. Beskonakli, and Y. Taskin Recombinant human erythropoietin decreases myeloperoxidase and caspase-3 activity and improves early functional results after spinal cord injury in rats J Clin Neurosci 14 2007 364 368
31. H. Qian, and D. Liu The time course of malondialdehyde production following impact injury to rat spinal cord as measured by microdialysis and high pressure liquid chromatography Neurochem Res 22 1997 1231 1236
32. J.D. Rothstein, and R.W. Kuncl Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity J Neurochem 65 1995 643 651
33. A. Stefani, F. Spadoni, and G. Bernardi Gabapentin inhibits calcium currents in isolated rat brain neurons Neuropharmacology 37 1998 83 91
34. P. Striano, and S. Striano Gabapentin: a Ca2+ channel alpha 2-delta ligand far beyond epilepsy therapy Drugs Today (Barc) 44 2008 353 368
35. C.H. Tator, and M.G. Fehlings Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms J Neurosurg 75 1991 15 26
36. C.P. Taylor, N.S. Gee, T.Z. Su, J.D. Kocsis, D.F. Welty, J.P. Brown, D.J. Dooley, P. Boden, and L. Singh A summary of mechanistic hypotheses of gabapentin pharmacology Epilepsy Res 29 1998 233 249
37. K. Tufan, N. Oztanir, E. Ofluoglu, C. Ozogul, N. Uzum, A. Dursun, H. Pasaoglu, and A. Pasaoglu Ultrastructure protection and attenuation of lipid peroxidation after blockade of presynaptic release of glutamate by lamotrigine in experimental spinal cord injury Neurosurg Focus 25 2008 E6
38. H. Usul, E. Arslan, T. Cansever, U. Cobanoglu, and S. Baykal Effects of clotrimazole on experimental spinal cord ischemia/reperfusion injury in rats Spine 33 2008 2863 2867
39. S. Wada, K. Yone, Y. Ishidou, T. Nagamine, S. Nakahara, T. Niiyama, and T. Sakou Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-D-aspartate receptor antagonist J Neurosurg 91 Suppl 1999 98 104
40. G. Wheeler Gabapentin Pfizer Curr Opin Investig Drugs 3 2002 470 477
41. N. Yazihan, K. Uzuner, B. Salman, M. Vural, T. Koken, and A. Arslantas Erythropoietin improves oxidative stress following spinal cord trauma in rats Injury 39 2008 1408 1413
42. W. Young Medical treatments of acute spinal cord injury J Neurol Neurosurg Psychiatry 55 1992 635 639
43. Y. Yu, Y. Matsuyama, M. Yanase, S. Ito, K. Adachi, K. Satake, N. Ishiguro, and K. Kiuchi Effects of hyperbaric oxygen on GDNF expression and apoptosis in spinal cord injury Neuroreport 15 2004 2369 2373
44. M. Zileli, F. zer, Spinal cord and spine surgery 1997 Saray zmir