Antinociception and (R,S)-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid antagonism by gabapentin in the rat spinal cord in vivo

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 362, Issue 2, 2000, Pages 197-200

  Chizh, B A ^a   Scheede, M ^a   Schlutz, H ^a  

^a GRÜNENTHAL GMBH   (Germany)

Author keywords

AMPA; Bicuculline; GABA; Gabapentin; NMDA; Nociception; Spinal cord; Wind up

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR ANTAGONIST; BICUCULLINE; GABAPENTIN; N METHYL DEXTRO ASPARTIC ACID;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG MECHANISM; DRUG SELECTIVITY; ELECTROSTIMULATION; EVOKED RESPONSE; IONTOPHORESIS; MALE; MECHANICAL STIMULATION; MOTOR UNIT; NOCICEPTIVE STIMULATION; NONHUMAN; RAT; SPINAL CORD DORSAL HORN;

ACETIC ACIDS; AMINES; ANALGESICS; ANESTHESIA; ANIMALS; BICUCULLINE; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, SPINAL; IONTOPHORESIS; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

EID: 0033898385     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000275     Document Type: Article

References (16)

1. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: A randomized controlled trial
2. 3-Substituted GABA analogs with central nervous system activity: A review
3. An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons
4. Gabapentin prevents hyperalgesia during the formalin test in diabetic rats
5. Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats
6. Thyrotropin-releasing hormone (TRH)-induced facilitation of spinal neurotransmission: A role for NMDA receptors
7. Stimulus intensity, cell excitation and the N-methyl-D-aspartate receptor component of sensory responses in the rat spinal cord in vivo
8. AMPA receptors have an equal role in spinal nociceptive and non-nociceptive transmission
9. A cure for wind-up: NMDA receptor antagonists as potential analgesics
10. Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat
11. Gabapentin for the treatment of postherpetic neuralgia: A randomized controlled trial
12. Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy
13. The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine
14. Gabapentin inhibits calcium currents in isolated rat brain neurons
15. A summary of mechanistic hypotheses of gabapentin pharmacology
16. 3H]-gabapentin with excitatory amino acid receptor and amino acid uptake site distributions in rat brain