Factors affecting residence time of Mesenchymal Stromal Cells (MSC) injected into the myocardium

Cell Transplantation

Volumn 19, Issue 8, 2010, Pages 937-948

  Westrich, Jason ^a,d   Yaeger, Peter ^a   He, Chufa ^a   Stewart, Jeff ^a   Chen, Raymond ^a   Seleznik, Gitta ^b,e   Larson, Shane ^c   Wentworth, Bruce ^a   O'Callaghan, Michael ^a   Wadsworth, Sam ^a   Akita, Geoffrey ^a   Molnar, Gyongyi ^a  

^a GENZYME CORPORATION   (United States)

^b HAESF Graduate Scholarship Program   (Hungary)

^c WORCESTER POLYTECHNIC INSTITUTE   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

^e UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Bone marrow stem stromal cells; Cell survival; Heart; IVIS; Luciferase reporter

Indexed keywords

CYCLOSPORIN A; IMMUNOGLOBULIN G; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULOTROPIN;

ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; FEMALE; GRAFT VERSUS HOST REACTION; HEART INFARCTION; HEART MUSCLE; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; LEWIS RAT; LOW DRUG DOSE; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; STROMA CELL;

ANIMALS; CELL SURVIVAL; CHEMOKINE CCL2; CYCLOSPORINE; GENES, REPORTER; IMAGING, THREE-DIMENSIONAL; INJECTIONS; INTERLEUKIN-6; INTERLEUKIN-8; LUCIFERASES, FIREFLY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOCARDIAL INFARCTION; MYOCARDIUM; RATS; RATS, INBRED LEW; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC; VASCULAR ENDOTHELIAL GROWTH FACTORS;

RATTUS;

EID: 77957802923     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X494911     Document Type: Article

References (51)

1. Amsalem, Y.; Mardor, Y.; Feinberg, M. S.; Landa, N.; Miller, L.; Daniels, D.; Ocherashvilli, A.; Holbova, R.; Yosef, O.; Barbash, I. M.; Leor, J. Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium. Circulation 116(11 Suppl.):I38-45; 2007.
2. Anderson, S. A.; Lee, K. K.; Frank, J. A. Gadolinium-fullerenol as a paramagnetic contrast agent for cellular imaging. Invest. Radiol. 41(3):332-338; 2006.
3. Beckermann, B. M.; Kallifatidis, G.; Groth, A.; Frommhold, D.; Apel, A.; Mattern, J.; Salnikov, A. V.; Moldenhauer, G.; Wagner, W.; Diehlmann, A.; Saffrich, R.; Schubert, M.; Ho, A. D.; Giese, N.; Büchler, M. W.; Friess, H.; Büchler, P.; Herr, I. VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma. Br. J. Cancer 99(4):622-631; 2008.
4. Britten, M. B.; Abolmaali, N. D.; Assmus, B.; Lehmann, R.; Honold, J.; Schmitt, J.; Vogl, T. J.; Martin, H.; Schachinger, V.; Dimmeler, S.; Zeiher, A. M. Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): Mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation 108(18):2212-2218; 2003.
5. Chen, L.; Tredget, E. E.; Wu, P. Y.; Wu, Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE 3(4):e1886; 2008. (Pubitemid 351943822)
6. Chin, B. B.; Nakamoto, Y.; Bulte, J. W.; Pittenger, M. F.; Wahl, R.; Kraitchman, D. L. 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction. Nucl. Med. Commun. 24(11):1149-1154; 2003.
7. Contag, C. H.; Spilman, S. D.; Contag, P. R.; Oshiro, M.; Eames, B.; Dennery, P.; Stevenson, D. K.; Benaron, D. A. Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem. Photobiol. 66(4):523-531; 1997.
8. Dai, W.; Hale, S. L.; Martin, B. J.; Kuang, J. Q.; Dow, J. S.; Wold, L. E.; Kloner, R. A. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: Short- and long-term effects. Circulation 112(2):214-223; 2005.
9. Freyman, T.; Polin, G.; Osman, H.; Crary, J.; Lu, M.; Cheng, L.; Palasis, M.; Wilensky, R. L. A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur. Heart J. 27(9):1114-1122; 2006.
10. Ghanem, A.; Ziomka, A.; Krausgrill, B.; Schenk, K.; Troatz, C.; Michalszki-Jamka, T.; Nickenig, G.; Tiemann, K.; Muller-Ehmsen, J. Functional impact of targeted closed-chest transplantation of bone marrow cells in rats with acute myocardial ischemia/reperfusion injury. Cell Transplant. 18:1289-1297; 2009.
11. Gnecchi, M.; Melo, L. G. Bone marrow-derived mesenchymal stem cells: Isolation, expansion, characterization, viral transduction, and production of conditioned medium. Methods Mol. Biol. 482:281-294; 2009.
12. Hare, J. M.; Traverse, J. H.; Henry, T. D.; Dib, N.; Strumpf, R. K.; Schulman, S. P.; Gerstenblith, G.; DeMaria, A. N.; Denktas, A. E.; Gammon, R. S.; Hermiller, Jr., J. B.; Reisman, M. A.; Schaer, G. L.; Sherman, W. A randomized, double-blind, placebo-controlled, dose escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J. Am. Coll. Cardiol. 54(24):2287-2289; 2009.
13. Hurtado, A.; Tseng, J. C.; Boivin, C.; Levin, B.; Yee, H.; Pampeno, C.; Meruelo, D. Identification of amino acids of Sindbis virus E2 protein involved in targeting tumor metastases in vivo. Mol. Ther. 12(5):813-823; 2005.
14. Ilagan, R.; Pottratz, J.; Le, K.; Zhang, L.; Wong, S. G.; Ayala, R.; Iyer, M.; Wu, L.; Gambhir, S. S.; Carey, M. Imaging mitogen-activated protein kinase function in xenograft models of prostate cancer. Cancer Res. 66(22):10778-10785; 2006. (Pubitemid 44876973)
15. Imanishi, Y.; Saito, A.; Komoda, H.; Kitagawa-Sakakida, S.; Miyagawa, S.; Kondoh, H.; Ichikawa, H.; Sawa, Y. Allogenic mesenchymal stem cell transplantation has a therapeutic effect in acute myocardial infarction in rats. J. Mol. Cell. Cardiol. 44(4):662-671; 2008.
16. Kraitchman, D. L.; Heldman, A. W.; Atalar, E.; Amado, L. C.; Martin, B. J.; Pittenger, M. F.; Hare, J. M.; Bulte, J. W. In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation 107(18):2290-2293; 2003.
17. Le Blanc, K. Mesenchymal stromal cells: Tissue repair and immune modulation. Cytotherapy 8(6):559-561; 2006. (Pubitemid 44869856)
18. Le Blanc, K.; Tammik, C.; Rosendahl, K.; Zetterberg, E.; Ringden, O. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp. Hematol. 31(10):890-896; 2003.
19. Leiker, M.; Suzuki, G.; Iyer, V. S.; Canty, Jr., J. M.; Lee, T. Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells. Cell Transplant. 17(8):911-922; 2008.
20. Li, S.; Tu, Q.; Zhang, J.; Stein, G.; Lian, J.; Yang, P. S.; Chen, J. Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration. J. Cell. Physiol. 215(1):204-209; 2008.
21. Lin, Y.; Molter, J.; Lee, Z.; Gerson, S. L. Bioluminescence imaging of hematopoietic stem cell repopulation in murine models. Methods Mol. Biol. 430:295-306; 2008.
22. Liu, C. H.; Hwang, S. M. Cytokine interactions in mesenchymal stem cells from cord blood. Cytokine 32(6):270-279; 2005.
23. Liu, K.; Chi, L.; Guo, L.; Liu, X.; Luo, C.; Zhang, S.; He, G. The interactions between brain microvascular endothelial cells and mesenchymal stem cells under hypoxic conditions. Microvasc. Res. 75(1):59-67; 2008.
24. Matsumoto, S.; Tanaka, F.; Sato, K.; Kimura, S.; Maekawa, T.; Hasegawa, S.; Wada, H. Monitoring with a non-invasive bioluminescent in vivo imaging system of pleural metastasis of lung carcinoma. Lung Cancer 66(1):75-79; 2009.
25. Min, J. J.; Ahn, Y.; Moon, S.; Kim, Y. S.; Park, J. E.; Kim, S. M.; Le, U. N.; Wu, J. C.; Joo, S. Y.; Hong, M. H. Yang, D. H.; Jeong, M. H.; Song, C. H.; Jeong, Y. H.; Yoo, K. Y.; Kang, K. S.; Bom, H. S. In vivo bioluminescence imaging of cord blood derived mesenchymal stem cell transplantation into rat myocardium. Ann. Nucl. Med. 20(3):165-170; 2006.
26. Muller-Ehmsen, J.; Whittaker, P.; Kloner, R. A.; Dow, J. S.; Sakoda, T.; Long, T. I.; Laird, P. W.; Kedes, L. Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J. Mol. Cell. Cardiol. 34(2):107-116; 2002.
27. Nagaya, N.; Fujii, T.; Iwase, T.; Ohgushi, H.; Itoh, T.; Uematsu, M.; Yamagishi, M.; Mori, H.; Kangawa, K.; Kitamura, S. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am. J. Physiol. Heart Circ. Physiol. 287(6):H2670-2676; 2004.
28. Nagaya, N.; Kangawa, K.; Itoh, T.; Iwase, T.; Murakami, S.; Miyahara, Y.; Fujii, T.; Uematsu, M.; Ohgushi, H.; Yamagishi, M.; Tokudome, T.; Mori, H.; Miyatake, K.; Kitamura, S. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 112(8):1128-1135; 2005.
29. Patel, A. N.; Spadaccio, C.; Kuzman, M.; Park, E.; Fischer, D. W.; Stice, S. L.; Mullangi, C.; Toma, C. Improved cell survival in infarcted myocardium using a novel combination transmyocardial laser and cell delivery system. Cell Transplant. 16(9):899-905; 2007. (Pubitemid 351448607)
30. Pittenger, M. F.; Martin, B. J. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ. Res. 95(1):9-20; 2004.
31. Quintavalla, J.; Uziel-Fusi, S.; Yin, J.; Boehnlein, E.; Pastor, G.; Blancuzzi, V.; Singh, H. N.; Kraus, K. H.; O'Byrne, E.; Pellas, T. C. Fluorescently labeled mesenchymal stem cells (MSCs) maintain multilineage potential and can be detected following implantation into articular cartilage defects. Biomaterials 23(1):109-119; 2002.
32. Robey, T. E.; Saiget, M. K.; Reinecke, H.; Murry, C. E. Systems approaches to preventing transplanted cell death in cardiac repair. J. Mol. Cell. Cardiol. 45(4):567-581; 2008.
33. Rocchetta, H. L.; Boylan, C. J.; Foley, J. W.; Iversen, P. W.; LeTourneau, D. L.; McMillian, C. L.; Contag, P. R.; Jenkins, D. E.; Parr, Jr., T. R. Validation of a noninvasive, real-time imaging technology using bioluminescent Escherichia coli in the neutropenic mouse thigh model of infection. Antimicrob. Agents Chemother. 45(1):129-137; 2001.
34. Sales, V. L.; Mettler, B. A.; Lopez-Ilasaca, M.; Johnson, Jr., J. A.; Mayer, Jr., J. E. Endothelial progenitor and mesenchymal stem cell-derived cells persist in tissue-engineered patch in vivo: Application of green and red fluorescent protein-expressing retroviral vector. Tissue Eng. 13(3):525-535; 2007.
35. Santos, K.; Simon, D. A.; Conway, E.; Bowers, W. J.; Mitra, S.; Foster, T. H.; Lugade, A.; Lord, E. M.; Federoff, H. J.; Dewhurst, S.; Frelinger, J. G. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: Implications for their use as immunization vectors. Hum. Gene Ther. 18(2):93-105; 2007.
36. Schuleri, K. H.; Amado, L. C.; Boyle, A. J.; Centola, M.; Saliaris, A. P.; Gutman, M. R.; Hatzistergos, K. E.; Oskouei, B. N.; Zimmet, J. M.; Young, R. G.; Heldman, A. W.; Lardo, A. C.; Hare, J. M. Early improvement in cardiac tissue perfusion due to mesenchymal stem cells. Am. J. Physiol. Heart Circ. Physiol. 294(5):H2002-2011; 2008.
37. Soriano, M. E.; Nicolosi, L.; Bernardi, P. Desensitization of the permeability transition pore by cyclosporin A prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-alpha. J. Biol. Chem. 279(35):36803-36808; 2004.
38. Sourdeval, M.; Lemaire, C.; Deniaud, A.; Taysse, L.; Daulon, S.; Breton, P.; Brenner, C.; Boisvieux-Ulrich, E.; Marano, F. Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis 11(9):1545-1559; 2006. (Pubitemid 44253672)
39. Swanger, S. A.; Neuhuber, B.; Himes, B. T.; Bakshi, A.; Fischer, I. Analysis of allogeneic and syngeneic bone marrow stromal cell graft survival in the spinal cord. Cell Transplant. 14(10):775-786; 2005. (Pubitemid 43152982)
40. Togel, F.; Yang, Y.; Zhang, P.; Hu, Z.; Westenfelder, C. Bioluminescence imaging to monitor the in vivo distribution of administered mesenchymal stem cells in acute kidney injury. Am. J. Physiol. Renal Physiol. 295(1):F315-321; 2008.
41. Troy, T.; Jekic-McMullen, D.; Sambucetti, L.; Rice, B. Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models. Mol. Imaging 3(1):9-23; 2004.
42. Tu, Q.; Zhang, J.; Fix, A.; Brewer, E.; Li, Y. P.; Zhang, Z. Y.; Chen, J. Targeted overexpression of BSP in osteoclasts promotes bone metastasis of breast cancer cells. J. Cell. Physiol. 218(1):135-145; 2009.
43. Wang, M.; Yang, Y.; Yang, D.; Luo, F.; Liang, W.; Guo, S.; Xu, J. The immunomodulatory activity of human umbilical cord blood-derived mesenchymal stem cells in vitro. Immunology 126(2):220-232; 2009.
44. Weir, C.; Morel-Kopp, M. C.; Gill, A.; Tinworth, K.; Ladd, L.; Hunyor, S. N.; Ward, C. Mesenchymal stem cells: Isolation, characterisation and in vivo fluorescent dye tracking. Heart Lung Circ. 17(5):395-403; 2008.
45. Wentworth, B. W.; Stewart, J.; Westrich, J.; He, C.; Blaksvedt, A.; Akita, G.; O'Callaghan, M.; Molnar, G.; Donovan, M.; Yaeger, P. Studies on the retention of cells delivered to the rat heart. European Society of Cardiology Annual Meeting Vienna, Austria. 2006.
46. Wu, J. C.; Inubushi, M.; Sundaresan, G.; Schelbert, H. R.; Gambhir, S. S. Optical imaging of cardiac reporter gene expression in living rats. Circulation 105(14):1631-1634; 2002.
47. Wu, J. C.; Sundaresan, G.; Iyer, M.; Gambhir, S. S. Non-invasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice. Mol. Ther. 4(4):297-306; 2001.
48. Xie, X.; Luo, Z.; Slawin, K. M.; Spencer, D. M. The EZC-prostate model: noninvasive prostate imaging in living mice. Mol. Endocrinol. 18(3):722-732; 2004.
49. Yoshihara, H.; Shumsky, J. S.; Neuhuber, B.; Otsuka, T.; Fischer, I.; Murray, M. Combining motor training with transplantation of rat bone marrow stromal cells does not improve repair or recovery in rats with thoracic contusion injuries. Brain Res. 1119(1):65-75; 2006. (Pubitemid 44647239)
50. Zakhartchenko, V. A.; Anderson, W. F.; Rozenberg, Y. Quantitation of retroviral-mediated transfer using luciferase in living and lysed cells. Biotechniques 31(3):676-681; 2001. (Pubitemid 32852650)
51. Zhang, M.; Methot, D.; Poppa, V.; Fujio, Y.; Walsh, K.; Murry, C. E. Cardiomyocyte grafting for cardiac repair: Graft cell death and anti-death strategies. J. Mol. Cell. Cardiol. 33(5):907-921; 2001.