MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia

Haematologica

Volumn 95, Issue 10, 2010, Pages 1713-1721

  Viny, Aaron D ^a,b   Clemente, Michael J ^b   Jasek, Monika ^b   Askar, Medhat ^b   Ishwaran, Hemant ^b   Nowacki, Amy ^b   Zhang, Aiwen ^b   Maciejewski, Jaroslaw P ^a,b  

^a CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Genome wide association study; GWAS; LGL; MICA; Neutropenia; SNP

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DNA; HEMOGLOBIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1 RELATED CHAIN A; METHOTREXATE; MONOCLONAL ANTIBODY; NATURAL KILLER CELL RECEPTOR NKG2D; PREDNISONE; PROTEIN MICA; UNCLASSIFIED DRUG;

ADULT; AGED; ANEMIA; ARTICLE; CLONAL VARIATION; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENOTYPE; GRANULOCYTE; HEMOGLOBIN BLOOD LEVEL; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; LARGE GRANULAR LYMPHOCYTE LEUKEMIA; LEUKEMIA CELL; LYMPHOCYTOTOXICITY; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NEUTROPENIA; NEUTROPHIL COUNT; POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; T CELL LARGE GRANULAR LYMPHOCYTE LEUKEMIA;

ADULT; AGED; AGED, 80 AND OVER; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC; MALE; MIDDLE AGED; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; POLYMORPHISM, GENETIC;

EID: 77957796079     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.021865     Document Type: Article

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