Monoclonal antibody-assisted stimulation of adenosine A2A receptors induces simultaneous downregulation of CXCR4 and CCR5 on CD4+ T-cells

Human Immunology

Volumn 71, Issue 11, 2010, Pages 1073-1076

  By, Youlet ^a   Durand Gorde, Josée Martine ^a   Condo, Jocelyne ^a   Lejeune, Pierre Jean ^a   Fenouillet, Emmanuel ^b   Guieu, Régis ^a   Ruf, Jean ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Mediterranée University   (France)

Author keywords

Adenosine A2A receptor; CCR5; CXCR4; HIV 1; Monoclonal antibody

Indexed keywords

ADENOSINE A2A RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; MONOCLONAL ANTIBODY;

ARTICLE; CD4+ T LYMPHOCYTE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; VIRUS ENTRY;

ADENOSINE A2 RECEPTOR AGONISTS; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; HUMANS; RECEPTOR, ADENOSINE A2A; RECEPTORS, CCR5; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION;

EID: 77957751748     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.08.010     Document Type: Article

References (26)

1. Huang S., Apasov S., Koshiba M., Sitkovsky M. Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion. Blood 1997, 90:1600-1610.
2. Koshiba M., Rosin D.L., Hayashi N., Linden J., Sitkovsky M.V. Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies. Mol Pharmacol 1999, 55:614-624.
3. Ohta A., Sitkovsky M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 2001, 414:916-920.
4. Ohta A., Gorelik E., Prasad S.J., Ronchese F., Lukashev D., Wong M.K., et al. A2A adenosine receptor protects tumors from antitumor T cells. Proc Natl Acad Sci U S A 2006, 103:13132-13137.
5. Koshiba M., Kojima H., Huang S., Apasov S., Sitkovsky M.V. Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells. J Biol Chem 1997, 272:25881-25889.
6. Armstrong J.M., Chen J.F., Schwarzschild M.A., Apasov S., Smith P.T., Caldwell C., et al. Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: Studies of cells from A2A-receptor-gene-deficient mice. Biochem J 2001, 354:123-130.
7. Viola A., Luster A.D. Chemokines and their receptors: Drug targets in immunity and inflammation. Annu Rev Pharmacol Toxicol 2008, 48:171-197.
8. Yeagle P.L., Albert A.D. G-protein coupled receptor structure. Biochim Biophys Acta 2007, 1768:808-824.
9. Marchese A., Paing M.M., Temple B.R., Trejo J.G. protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol 2008, 48:601-629.
10. Gurevich V.V., Gurevich E.V. The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol Ther 2006, 110:465-502.
11. Zhang N., Yang D., Dong H., Chen Q., Dimitrova D.I., Rogers T.J., et al. Adenosine A2a receptors induce heterologous desensitization of chemokine receptors. Blood 2006, 108:38-44.
12. Contento R.L., Molon B., Boularan C., Pozzan T., Manes S., Marullo S., et al. CXCR4-CCR5: A couple modulating T cell functions. Proc Natl Acad Sci U S A 2008, 105:10101-10106.
13. By Y., Durand-Gorde J.M., Condo J., Lejeune P.J., Mallet B., Carayon P., et al. Production of an agonist-like monoclonal antibody to the human A2A receptor of adenosine for clinical use. Mol Immunol 2009, 46:400-405.
14. Ruf J., Tonnelle C., Rocca-Serra J., Moinier D., Pierres M., Ju S.T., et al. Structural bases for public idiotypic specificities of monoclonal antibodies directed against poly(Glu60Ala30Tyr10) and poly(Glu60Ala40) random copolymers. Proc Natl Acad Sci U S A 1983, 80:3040-3044.
15. Minguet S., Huber M., Rosenkranz L., Schamel W.W., Reth M., Brummer T. Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors. Eur J Immunol 2005, 35:31-41.
16. Canals M., Burgueno J., Marcellino D., Cabello N., Canela E.I., Mallol J., et al. Homodimerization of adenosine A2A receptors: Qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Neurochem 2004, 88:726-734.
17. Mijares A., Lebesgue D., Wallukat G., Hoebeke J. From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-beta(2)-adrenoceptor antibody behave as antagonists. Mol Pharmacol 2000, 58:373-379.
18. Palmer T.M., Gettys T.W., Jacobson K.A., Stiles G.L. Desensitization of the canine A2a adenosine receptor: Delineation of multiple processes. Mol Pharmacol 1994, 45:1082-1094.
19. Klaasse E.C., IJzerman A.P., de Grip W.J., Beukers M.W. Internalization and desensitization of adenosine receptors. Purinergic Signal 2008, 4:21-37.
20. Zezula J., Freissmuth M., The A. (2A)-adenosine receptor: A GPCR with unique features?. Br J Pharmacol 2008, 153(Suppl 1):S184-S190.
21. Chan D.C., Kim P.S. HIV entry and its inhibition. Cell 1998, 93:681-684.
22. Dimitrov D.S. How do viruses enter cells?. The HIV coreceptors teach us a lesson of complexity. Cell 1997, 91:721-730.
23. Moore J.P., Trkola A., Dragic T. Co-receptors for HIV-1 entry. Curr Opin Immunol 1997, 9:551-562.
24. Simmons G., Wilkinson D., Reeves J.D., Dittmar M.T., Beddows S., Weber J., et al. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. J Virol 1996, 70:8355-8360.
25. Schlecht H.P., Schellhorn S., Dezube B.J., Jacobson J.M. New approaches in the treatment of HIV/A. Ther Clin. Risk Manag 2008, 4:473-485.
26. Lin Y.L., Mettling C., Portales P., Reynes J., Clot J., Corbeau P. Cell surface CCR5 density determines the postentry efficiency of R5 HIV-1 infection. Proc Natl Acad Sci U S A 2002, 99:15590-15595.