Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1

Acta Pharmacologica Sinica

Volumn 31, Issue 10, 2010, Pages 1284-1292

  Zhang, Dong Juan ^a,b   Chen, Li Hong ^a,b   Zhang, Ya Hua ^c   Yang, Guang Rui ^a,b   Dou, Dou ^a   Gao, Yuan Sheng ^a   Zhang, Xiao Yan ^a,b   Kong, Xiao Mu ^a,b   Zhao, Pan ^a,b   Pu, Dan ^a,b   Wei, Ming Fen ^a,b   Breyer, Matthew D ^c   Guan, You Fei ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

angiotensin II; blood pressure; membrane associated prostaglandin E2 synthase 1; prostaglandin E2; resistant vessel

Indexed keywords

ANGIOTENSIN II; PROSTAGLANDIN E2 DERIVATIVE; PROSTAGLANDIN E2 SYNTHASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CATHETERIZATION; ARTERY DISSECTION; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CAROTID ARTERY; CONTROLLED STUDY; EX VIVO STUDY; GENOTYPE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; JUGULAR VEIN; KIDNEY ARTERY; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; MOUSE; NONHUMAN; PRESSOR RESPONSE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; THORACIC AORTA; VASCULAR SMOOTH MUSCLE; WILD TYPE;

ANGIOTENSIN II; ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; DINOPROSTONE; DIURESIS; IMMUNOHISTOCHEMISTRY; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM; STRESS, MECHANICAL; VASOCONSTRICTOR AGENTS;

EID: 77957740227     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.99     Document Type: Article

References (55)

1. Samuelsson B, Morgenstern R, Jakobsson PJ. Membrane prostaglandin E synthase-1: a novel therapeutic target. Pharmacol Rev 2007;59:207-24.
2. Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B. Characterization of microsomal, glutathione dependent prostaglandin E synthase. Adv Exp Med Biol 2002;507:287-91.
3. Thoren S, Weinander R, Saha S, Jegerschold C, Pettersson PL, Samuelsson B, et al. Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem 2003;278:22199-209.
4. Han R, Tsui S, Smith TJ. Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fbroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression. J Biol Chem 2002;277:16355-64.
5. Shinji Y, Tsukui T, Tatsuguchi A, Shinoki K, Kusunoki M, Suzuki K, et al. Induced microsomal PGE synthase-1 is involved in cyclooxygenase-2-dependent PGE2 production in gastric fibroblasts. Am J Physiol Gastrointest Liver Physiol 2005;288: G308-15.
6. Murakami M, Kudo I. Prostaglandin E synthase: a novel drug target for infammation and cancer. Curr Pharm Des 2006;12:943-54.
7. Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, et al. Impaired infammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A 2003;100:9044-9.
8. Friesen RW, Mancini JA. Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-infammatory therapeutic target. J Med Chem 2008;51:4059-67.
9. Soodvilai S, Jia Z, Wang MH, Dong Z, Yang T. mPGES-1 deletion impairs diuretic response to acute water loading. Am J Physiol Renal Physiol 2009;296: F1129-35.
10. Murakami M, Naraba H, Tanioka T, Semmyo N, Nakatani Y, Kojima F, et al. Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem 2000;275:32783-92.
11. von Rahden BH, Stein HJ, Hartl SA, Theisen J, Stigler B, Siewert JR, et al. Expression of prostaglandin E synthase in Barrett's cancer. Dis Esophagus 2008;21:304-8.
12. Watanabe K, Kurihara K, Suzuki T. Purifcation and characterization of membrane-bound prostaglandin E synthase from bovine heart. Biochim Biophys Acta 1999;1439:406-14.
13. Tanikawa N, Ohmiya Y, Ohkubo H, Hashimoto K, Kangawa K, Kojima M, et al. Identifcation and characterization of a novel type of membraneassociated prostaglandin E synthase. Biochem Biophys Res Commun 2002;291:884-9.
14. Murakami M, Nakashima K, Kamei D, Masuda S, Ishikawa Y, Ishii T, et al. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and-2. J Biol Chem 2003;278:37937-47.
15. Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I. Mole cular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate pro staglandin E2 bio synthesis. J Biol Chem 2000;275:32775-82.
16. Gudis K, Tatsuguchi A, Wada K, Futagami S, Nagata K, Hiratsuka T, et al. Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue. Lab Invest 2005;85:225-36.
17. Guan Y, Zhang Y, Wu J, Qi Z, Yang G, Dou D, et al. Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting. J Clin Invest 2007;117:2496-505.
18. Zhang Y, Guan Y, Schneider A, Brandon S, Breyer RM, Breyer MD. Characterization of murine vasopressor and vasodepressor prostaglandin E (2) receptors. Hypertension 2000;35:1129-34.
19. Hao CM, Breyer MD. Physiological regulation of prostaglandins in the kidney. Annu Rev Physiol 2008;70:357-77.
20. Hao CM, Breyer MD. Physiologic and pathophysiologic roles of lipid mediators in the kidney. Kidney Int 2007;71:1105-15.
21. Breyer MD, Breyer RM. G protein-coupled prostanoid receptors and the kidney. Annu Rev Physiol 2001;63:579-605.
22. Izhar M, Alausa T, Folker A, Hung E, Bakris GL. Effects of COX inhibition on blood pressure and kidney function in ACE inhibitor-treated blacks and hispanics. Hypertension 2004;43:573-7.
23. Sowers JR, White WB, Pitt B, Whelton A, Simon LS, Winer N, et al. The effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension, osteoarthritis, and type 2 diabetes mellitus. Arch Intern Med 2005;165:161-8.
24. Grosser T, Fries S, FitzGerald GA. Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic chal lenges and opportunities. J Clin Invest 2006;116:4-15.
25. Farkouh ME, Kirshner H, Harrington RA, Ruland S, Verheugt FW, Schnitzer TJ, et al. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial. Lancet 2004;364:675-84.
26. Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2005;352:1092-102.
27. Zhang J, Ding EL, Song Y. Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. Jama 2006;296:1619-32.
28. Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med 2000;343:1520-8, 2 p following 28.
29. Jia Z, Zhang A, Zhang H, Dong Z, Yang T. Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion. Circ Res 2006;99:1243-51.
30. Jia Z, Guo X, Zhang H, Wang MH, Dong Z, Yang T. Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress. Hypertension 2008;52:952-9.
31. Francois H, Facemire C, Kumar A, Audoly L, Koller B, Coffman T. Role of microsomal prostaglandin E synthase 1 in the kidney. J Am Soc Nephrol 2007;18:1466-75.
32. Cheng Y, Wang M, Yu Y, Lawson J, Funk CD, Fitzgerald GA. Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest 2006;116:1391-9.
33. Qi Z, Hao CM, Langenbach RI, Breyer RM, Redha R, Morrow JD, et al. Opposite effects of cyclooxygenase-1 and -. activity on the pressor response to angiotensin II. J Clin Invest 2002;110:61-9.
34. Uematsu S, Matsumoto M, Takeda K, Akira S. Lipopolysaccharidedependent prostaglandin E (2) production is regulated by the glutathione-dependent prostaglandin E (2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J Immunol 2002;168:5811-6.
35. Yang G, Chen L, Zhang Y, Zhang X, Wu J, Li S, et al. Expression of mouse membrane-associated prostaglandin E2 synthase-2 (mPGES-2) along the urogenital tract. Biochim Biophys Acta 2006;1761:1459-68.
36. Guo Z, Van Remmen H, Yang H, Chen X, Mele J, Vijg J, et al. Changes in expression of antioxidant enzymes affect cell-mediated LDL oxida tion and oxidized LDL-induced apoptosis in mouse aortic cells. Arterioscler Thromb Vasc Biol 2001;21:1131-8.
37. Wang X, Tong M, Chinta S, Raj JU, Gao Y. Hypoxia-induced reactive oxygen species downregulate ETB receptor-mediated contraction of rat pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 2006;290: L570-8.
38. LaCroix C, Freeling J, Giles A, Wess J, Li YF. Defciency of M2 muscarinic acetylcholine receptors increases susceptibility of ven tri cular function to chronic adrenergic stress. Am J Physiol Heart Circ Physiol 2008;294: H810-20.
39. Yang T. Microsomal prostaglandin E synthase-1 and blood pressure regulation. Kidney Int 2007;72:274-8.
40. Fierro-Carrion GA, Ram CV. Nonsteroidal anti-inflammatory drugs (NSAIDs) and blood pressure. Am J Cardiol 1997;80:775-6.
41. Siragy HM, Senbonmatsu T, Ichiki T, Inagami T, Carey RM. Increased renal vasodilator prostanoids prevent hypertension in mice lacking the angiotensin subtype-2 receptor. J Clin Invest 1999;104:181-8.
42. Feuerstein G, Adelberg SA, Kopin IJ, Jacobowitz DM. Hypothalamic sites for cardiovascular and sympathetic modulation by prostaglandin E2. Brain Res 1982;231:335-42.
43. Hristovska AM, Rasmussen LE, Hansen PB, Nielsen SS, Nusing RM, Narumiya S, et al. Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase. Hypertension 2007;50:525-30.
44. Ueno N, Takegoshi Y, Kamei D, Kudo I, Murakami M. Coupling between cyclooxygenases and terminal prostanoid synthases. Biochem Biophys Res Commun 2005;338:70-6.
45. Chandrasekharan S, Foley NA, Jania L, Clark P, Audoly LP, Koller BH. Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland. J Lipid Res 2005;46:2636-48.
46. Vila L. Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: role in atherosclerosis. Med Res Rev 2004;24:399-424.
47. Davidge ST. Prostaglandin H synthase and vascular function. Circ Res 2001;89:650-60.
48. Soler M, Camacho M, Escudero JR, Iniguez MA, Vila L. Human vascular smooth muscle cells but not endothelial cells express prostaglandin E synthase. Circ Res 2000;87:504-7.
49. Morinelli TA, Walker LP, Ullian ME. COX-2 expression stimulated by angiotensin II depends upon AT1 receptor internalization in vascular smooth muscle cells. Biochim Biophys Acta 2008;1783:1048-54.
50. Jaimes EA, Zhou MS, Pearse DD, Puzis L, Raij L. Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species. Am J Physiol Renal Physiol 2008;294: F385-92.
51. Young W, Mahboubi K, Haider A, Li I, Ferreri NR. Cyclooxygenase-2 is required for tumor necrosis factor-alpha-and angiotensin II-mediated proliferation of vascular smooth muscle cells. Circ Res 2000;86:906-14.
52. Cheng HF, Harris RC. Cyclooxygenases, the kidney, and hypertension. Hypertension 2004;43:525-30.
53. Camacho M, Gerboles E, Escudero JR, Anton R, Garcia-Moll X, Vila L. Microsomal prostaglandin E synthase-1, which is not coupled to a particular cyclooxygenase isoenzyme, is essential for prostaglandin E (2) biosynthesis in vascular smooth muscle cells. J Thromb Haemost 2007;5:1411-9.
54. Breyer MD, Breyer RM. Prostaglandin E receptors and the kidney. Am J Physiol Renal Physiol 2000;279: F12-23.
55. Facemire CS, Griffiths R, Audoly LP, Koller BH, Coffman TM. The impact of microsomal prostaglandin E synthase 1 on blood pressure is determined by genetic background. Hypertension 2010;55:531-8.