Krüppel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCs

Acta Pharmacologica Sinica

Volumn 31, Issue 10, 2010, Pages 1293-1302

  Zhang, Rui ^a   Han, Mei ^a   Zheng, Bin ^a   Li, Ying Jie ^a   Shu, Ya Nan ^a   Wen, Jin Kun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

all trans retinoic acid; Kr ppel like factor 4; mitofusin 2; p300; vascular smooth muscle cells

Indexed keywords

ADENOVIRUS VECTOR; GLUTATHIONE TRANSFERASE; KRUPPEL LIKE FACTOR 4; LUCIFERASE; MITOFUSIN 2; PROTEIN P300; RETINOIC ACID;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CHROMATIN IMMUNOPRECIPITATION; ENZYME ASSAY; MALE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SMOOTH MUSCLE FIBER; THORACIC AORTA; TRANSACTIVATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ACETYLATION; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; E1A-ASSOCIATED P300 PROTEIN; GENE EXPRESSION REGULATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION, GENETIC; TRETINOIN; ZINC FINGERS;

EID: 77957732014     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.96     Document Type: Article

References (34)

1. Rowland BD, Bernards R, Peeper DS. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 2005;7:1074-82.
2. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007;448:313-7.
3. Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, et al. In vitro reprogramming of fbroblasts into a pluripotent ES-celllike state. Nature 2007;448:318-24.
4. Shie JL, Chen ZY, Fu M, Pestell RG, Tseng CC. Gut-enriched Krüppellike factor represses cyclin D1 promoter activity through Sp1 motif. Nucleic Acids Res 2000;28:2969-76.
5. Wei D, Kanai M, Jia Z, Le X, Xie K. Krüppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res 2008;68:4631-9.
6. Hinnebusch BF, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, et al. Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Krüppel-like factor. Am J Physiol Gastrointest Liver Physiol 2004;286: G23-30. (Pubitemid 38055832)
7. Swamynathan SK, Katz JP, Kaestner KH, Ashery-Padan R, Crawford MA, Piatigorsky J. Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol 2007;27:182-94.
8. Wassmann S, Wassmann K, Jung A, Velten M, Knuefermann P, Petoumenos V, et al. Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. J Mol Cell Cardiol 2007;43:301-7.
9. Jiang GJ, Han M, Zheng B, Wen JK. Hyperplasia suppressor gene associates with smooth muscle alpha-actin and is involved in the redifferentiation of vascular smooth muscle cells. Heart Vessels 2006;21:315-20.
10. Wang C, Han M, Zhao XM, Wen JK. Krüppel-like factor 4 is required for the expression of vascular smooth muscle cell differentiation marker genes induced by all-trans retinoic acid. J Biochem 2008;144:313-21.
11. Bach D, Pich S, Soriano FX, Vega N, Baumgartner B, Oriola J, et al. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem 2003;278:17190-7.
12. Pich S, Bach D, Briones P, Liesa M, Camps M, Testar X, et al. The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum Mol Genet 2005;14:1405-15.
13. Wu L, Li Z, Zhang Y, Zhang P, Zhu X, Huang J, et al. Adenovirusexpressed human hyperplasia suppressor gene induces apoptosis in cancer cells. Mol Cancer Ther 2008;7:222-32.
14. Chen KH, Guo X, Ma D, Guo Y, Li Q, Yang D, et al. Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol 2004;6:872-83.
15. Guo X, Chen KH, Guo Y, Liao H, Tang J, Xiao RP. Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway. Circ Res 2007;101:1113-22.
16. Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, et al. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. J Biol Chem 2007;282:23354-61.
17. Li Y, Yin R, Liu J, Wang P, Wu S, Luo J, et al. Peroxisome proliferatoractivated receptor delta regulates mitofusin 2 expression in the heart. J Mol Cell Cardiol 2009;46:876-82.
18. Zheng B, Wen JK, Han M. hhLIM is involved in cardiomyogenesis of embryonic stem cells. Biochemistry (Mosc) 2006;71 Suppl 1: S71-6.
19. Liu B, Han M, Wen JK. Acetylbritannilactone inhibits neointimal hyperplasia after balloon injury of rat artery by suppressing nuclear factor-{kappa}B activation. J Pharmacol Exp Ther 2008;324:292-8.
20. Zheng B, Han M, Bernier M, Zhang XH, Meng F, Miao SB, et al. Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alphamediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells. J Biol Chem 2009;284:22773-85.
21. Zheng B, Han M, Wen JK, Zhang R. Human heart LIM protein activates atrial-natriuretic-factor gene expression by interacting with the cardiac-restricted transcription factor Nkx2.5. Biochem J 2008;409:683-90.
22. Li AY, Han M, Zheng B, Wen JK. Roscovitine inhibits ERK1/2 activation induced by angiotensin II in vascular smooth muscle cells. FEBS Lett 2008;582:243-8.
23. Zhang XH, Zheng B, Han M, Miao SB, Wen JK. Synthetic retinoid Am80 inhibits interaction of KLF5 with RAR alpha through inducing KLF5 dephosphorylation mediated by the PI3K/Akt signaling in vascular smooth muscle cells. FEBS Lett 2009;583:1231-6.
24. Dornan D, Shimizu H, Perkins ND, Hupp TR. DNA-dependent acetylation of p53 by the transcription coactivator p300. J Biol Chem 2003;278:13431-41.
25. Hansson ML, Popko-Scibor AE, Saint Just Ribeiro M, Dancy BM, Lindberg MJ, Cole PA, et al. The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity. Nucleic Acids Res 2009;37:2996-3006.
26. Evans PM, Zhang W, Chen X, Yang J, Bhakat KK, Liu C. Krüppellike factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem 2007;282:33994-4002.
27. Hayashi K, Takahashi M, Kimura K, Nishida W, Saga H, Sobue K. Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells. J Cell Biol 1999;145:727-40.
28. Zhan Y, Kim S, Izumi Y, Izumiya Y, Nakao T, Miyazaki H, et al. Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression. Arterioscler Thromb Vasc Biol 2003;23:795-801.
29. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, et al. Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain. Mol Cell Biol 2003;23:8528-41.
30. Meng F, Han M, Zheng B, Wang C, Zhang R, Zhang XH, et al. Alltrans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells. Biochem Biophys Res Commun 2009;387:13-8.
31. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 1993;365:855-9.
32. Zhang Z, Teng CT. Phosphorylation of Krüppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. Nucleic Acids Res 2003;31:2196-208.
33. Kramer OH, Knauer SK, Greiner G, Jandt E, Reichardt S, Guhrs KH, et al. A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev 2009;23:223-35.
34. Asano Y, Trojanowska M. Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta. Mol Cell Biol 2009;29:1882-94.