Synthetic retinoid Am80 inhibits interaction of KLF5 with RARα through inducing KLF5 dephosphorylation mediated by the PI3K/Akt signaling in vascular smooth muscle cells

FEBS Letters

Volumn 583, Issue 8, 2009, Pages 1231-1236

  Zhang, Xin hua ^a   Zheng, Bin ^a   Han, Mei ^a   Miao, Sui bing ^a   Wen, Jin kun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Kr ppel like factor 5; p38 mitogen activated protein kinase; PI3K Akt; Retinoic acid receptor ; Retinoid; Vascular smooth muscle cell

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; KRUPPEL LIKE FACTOR 5; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RETINOIC ACID RECEPTOR ALPHA; RETINOID; TAMIBAROTENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BALLOON; CAROTID ARTERY INJURY; CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RESTENOSIS; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BENZOATES; CELLS, CULTURED; CHROMONES; ENZYME INHIBITORS; IMMUNOPRECIPITATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MORPHOLINES; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, RETINOIC ACID; RETINOIDS; SIGNAL TRANSDUCTION; TETRAHYDRONAPHTHALENES;

EID: 64049092045     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.03.016     Document Type: Article

References (25)

1. Bieker J.J. Krüppel-like factors: three fingers in many pies. J. Biol. Chem. 276 (2001) 34355-34358
2. Dang D.T., Pevsner J., and Yang V.W. The biology of the mammalian Krüppel-like family of transcription factors. Int. J. Biochem. Cell Biol. 32 (2000) 1103-1121
3. Ghaleb A.M., Nandan M.O., Chanchevalap S., Dalton W.B., Hisamuddin I.M., and Yang V.W. Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res. 15 (2005) 92-96
4. Bateman N.W., Tan D., Pestell R.G., Black J.D., and Black A.R. Intestinal tumor progression is associated with altered function of KLF5. J. Biol. Chem. 279 (2004) 12093-12101
5. Nandan M.O., Chanchevalap S., Dalton W.B., and Yang V.W. Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation. FEBS Lett. 579 (2005) 4757-4762
6. Nandan M.O., Yoon H.S., Zhao W., Ouko L.A., Chanchevalap S., and Yang V.W. Kruppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene 23 (2004) 3404-3413
7. Aizawa K., Suzuki T., Kada N., Ishihara A., Kawai-Kowase K., Matsumura T., Sasaki K., Munemasa Y., Manabe I., Kurabayashi M., Collins T., and Nagai R. Regulation of platelet-derived growth factor-A chain by Krüppel-likefactor 5: new pathway of cooperative activation with nuclear factor-κB. J. Biol. Chem. 279 (2004) 70-76
8. Shindo T., Manabe I., Fukushima Y., Tobe K., Aizawa K., Miyamoto S., Kawai-Kowase K., Moriyama N., Imai Y., Kawakami H., Nishimatsu H., Ishikawa T., Suzuki T., Morita H., Maemura K., Sata M., Hirata Y., Komukai M., Kagechika H., Kadowaki T., Kurabayashi M., and Nagai R. Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat. Med. 8 (2002) 856-863
9. Fujiu K., Manabe I., Ishihara A., Oishi Y., Iwata H., Nishimura G., Shindo T., Maemura K., Kagechika K., Shudo K., and Nagai R. Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5. Circ. Res. 97 (2005) 1132-1141
10. Manabe I., and Nagai R. Regulation of smooth muscle phenotype. Curr. Atheroscler. Rep. 5 (2003) 214-222
11. Owens G.K., Kumar M.S., and Wamhoff B.R. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol. Rev. 84 (2004) 767-801
12. Bastien J., and Rochette-Egly C. Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene 328 (2004) 1-16
13. Han M., Wen J.K., Zheng B., Cheng Y.H., and Zhang C. Serum deprivation results in redifferentiation of human umbilical vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 291 (2006) C50-C58
14. Han J., Lee J.D., Jiang Y., Li Z., Feng L., and Ulevitch R.J. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J. Biol. Chem. 271 (1996) 2886-2891
15. Zheng B., Wen J.K., and Han M. HhLIM is a novel F-actin binding protein involved in actin cytoskeleton remodeling. FEBS J. 275 (2008) 1568-7158
16. Liu B., Han M., and Wen J.K. Acetylbritannilactone inhibits neointimal hyperplasia after balloon injury of rat artery by suppressing nuclear factor-κB activation. J. Pharmacol. Exp. Ther. 324 (2008) 292-298
17. Jiang G.J., Han M., Zheng B., and Wen J.K. Hyperplasia suppressor gene associates with smooth muscle alpha-actin and is involved in the redifferentiation of vascular smooth muscle cells. Heart Vessels. 21 (2006) 315-320
18. Kada N., Suzuki T., Aizawa K., Munemasa Y., Matsumura T., Sawaki D., and Nagai R. Acyclic retinoid inhibits functional interaction of transcription factors Kruppel-like factor 5 and retinoic acid receptor-alpha. FEBS Lett. 582 (2008) 1755-1760
19. Gianni M., Kopf E., Bastien J., Oulad-Abdelghani M., Garattini E., Chambon P., and Rochette-Egly C. Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor γ2. J. Biol. Chem. 277 (2002) 24859-24862
20. Taniyama Y., Ushio-Fukai M., Hitomi H., Rocic P., Kingsley M.J., Pfahnl C., Weber D.S., Wayne Alexander R., and Griendling K.K. Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 287 (2004) C494-C499
21. Miyamoto S., Suzuki T., Muto S., Aizawa K., Kimura A., Mizuno Y., Nagino T., Imai Y., Adachi N., Horikoshi M., and Nagai R. Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain. Mol. Cell Biol. 23 (2003) 8528-8541
22. Matsumura T., Suzuki T., Aizawa K., Munemasa Y., Muto S., Horikoshi M., and Nagai R. The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction. J. Biol. Chem. 280 (2005) 12123-12129
23. Chrivia J.C., Kwok R.P., Lamb N., Hagiwara M., Montminy M.R., and Goodman R.H. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365 (1993) 855-859
24. Zhang Z., and Teng C.T. Phosphorylation of Krüppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. Nucleic Acids Res. 31 (2003) 2196-2208
25. Gervais M., Dugourd C., Muller L., Ardidie C., Canton B., Loviconi L., Corvol P., Chneiweiss H., and Monnot C. Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15. Mol. Biol. Cell 17 (2006) 3940-3951