Medication and Falls: Risk and Optimization

Clinics in Geriatric Medicine

Volumn 26, Issue 4, 2010, Pages 583-605

  Boyle, Nichola ^a,b   Naganathan, Vasi ^a,b   Cumming, Robert G ^a,c  

^a Department of Microbiology and Infectious Diseases   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Falls; Medication; Older people; Polypharmacy

Indexed keywords

AMITRIPTYLINE; ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE; CARDIOVASCULAR AGENT; CENTRAL NERVOUS SYSTEM AGENTS; CHOLINERGIC RECEPTOR BLOCKING AGENT; DIAZEPAM; ESZOPICLONE; HYPNOTIC SEDATIVE AGENT; IBUPROFEN; LONG ACTING DRUG; MORPHINE; NARCOTIC ANALGESIC AGENT; NEUROLEPTIC AGENT; OLANZAPINE; PROPRANOLOL; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SHORT ACTING DRUG; TETRACYCLIC ANTIDEPRESSANT AGENT; THIORIDAZINE; TRAZODONE; UNINDEXED DRUG; VERAPAMIL; ZOLPIDEM;

ADVERSE OUTCOME; AGING; ALZHEIMER DISEASE; BALANCE IMPAIRMENT; BONE DENSITY; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DEPRESSION; DIZZINESS; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLASSIFICATION; DRUG DISTRIBUTION; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MEGADOSE; DRUG SAFETY; DRUG TRANSFORMATION; DRUG USE; DRUG WITHDRAWAL; EVIDENCE BASED MEDICINE; EXTRAPYRAMIDAL SYMPTOM; FALL RISK ASSESSMENT; FALLING; GAIT DISORDER; GERIATRIC ASSESSMENT; GERIATRIC CARE; HEALTH EDUCATION; HEART ARRHYTHMIA; HIGH RISK POPULATION; HIP FRACTURE; HUMAN; HYPOTENSION; LIMB WEAKNESS; NEUROLOGIC DISEASE; ORTHOSTATIC HYPERTENSION; ORTHOSTATIC HYPOTENSION; POLYPHARMACY; POSTPRANDIAL HYPOTENSION; PRESCRIPTION; PREVENTION STUDY; REVIEW; RISK BENEFIT ANALYSIS; RISK REDUCTION; SEDATION; SIDE EFFECT; SOMNOLENCE;

ACCIDENTAL FALLS; AGED; AGING; CENTRAL NERVOUS SYSTEM AGENTS; HUMANS; POLYPHARMACY; RESIDENTIAL FACILITIES; RISK;

EID: 77957730837     PISSN: 07490690     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cger.2010.06.007     Document Type: Review

References (116)

1. Beijer H.J., de Blaey C.J., Beijer H.J. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci 2002, 24(2):46-54.
2. Zhang M., Holman C.D., Preen D.B., et al. Repeat adverse drug reactions causing hospitalization in older Australians: a population-based longitudinal study 1980-2003. Br J Clin Pharmacol 2007, 63(2):163-170.
3. Bjerrum L., Rosholm J.U., Hallas J., et al. Methods for estimating the occurrence of polypharmacy by means of a prescription database. Eur J Clin Pharmacol 1997, 53(1):7-11.
4. Kennerfalk A., Ruigomez A., Wallander M.A., et al. Geriatric drug therapy and healthcare utilization in the United kingdom. Ann Pharmacother 2002, 36(5):797-803.
5. Kaufman D.W., Kelly J.P., Rosenberg L., et al. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA 2002, 287(3):337-344.
6. Cresswell K.M., Fernando B., Mckinstry B., et al. Adverse drug events in the elderly. Br Med Bull 2007, 83(1):259-274.
7. Herrlinger C., Klotz U. Drug metabolism and drug interactions in the elderly. Baillieres Best Pract Res Clin Gastroenterol 2001, 15(6):897-918.
8. Mallet L., Spinewine A., Huang A., et al. The challenge of managing drug interactions in elderly people. Lancet 2007, 370(9582):185-191.
9. Newton J.L., Newton J.L. Effect of age-related changes in gastric physiology on tolerability of medications for older people. Drugs Aging 2005, 22(8):655-661.
10. Ramsay S.E., Whincup P.H., Shaper A.G., et al. The relations of body composition and adiposity measures to ill health and physical disability in elderly men. Am J Epidemiol 2006, 164(5):459-469.
11. Klotz U., Avant G.R., Hoyumpa A., et al. The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Invest 1975, 55(2):347-359.
12. Le Couteur D.G., Mclean A.J. The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis. Clin Pharmacokinet 1998, 34(5):359-373.
13. Beck L.H. Changes in renal function with aging. Clin Geriatr Med 1998, 14(2):199-209.
14. Mclean A.J., Le Couteur D.G., Mclean A.J., et al. Aging biology and geriatric clinical pharmacology. Pharmacol Rev 2004, 56(2):163-184.
15. Fliser D., Franek E., Joest M., et al. Renal function in the elderly: impact of hypertension and cardiac function. Kidney Int 1997, 51(4):1196-1204.
16. Aichhorn W., Weiss U., Marksteiner J., et al. Influence of age and gender on risperidone plasma concentrations. J Psychopharmacol 2005, 19(4):395-401.
17. Albrecht S., Ihmsen H., Hering W., et al. The effect of age on the pharmacokinetics and pharmacodynamics of midazolam. Clin Pharmacol Ther 1999, 65(6):630-639.
18. Leipzig R.M., Cumming R.G., Tinetti M.E. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 1999, 47(1):30-39.
19. Leipzig R.M., Cumming R.G., Tinetti M.E. Drugs and falls in older people: a systematic review and meta-analysis: II. Cardiac and analgesic drugs. J Am Geriatr Soc 1999, 47(1):40-50.
20. Woolcott J.C., Richardson K.J., Wiens M.O., et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 2009, 169(21):1952-1960.
21. Campbell A.J., Borrie M.J., Spears G.F. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol 1989, 44(4):M112-M117.
22. Tromp A.M., Pluijm S.M., Smit J.H., et al. Fall-risk screening test: a prospective study on predictors for falls in community-dwelling elderly. J Clin Epidemiol 2001, 54(8):837-844.
23. Tinetti M.E., Liu W.L., Claus E.B. Predictors and prognosis of inability to get up after falls among elderly persons. JAMA 1993, 269(1):65-70.
24. Studenski S., Duncan P.W., Chandler J., et al. Predicting falls: the role of mobility and nonphysical factors. J Am Geriatr Soc 1994, 42(3):297-302.
25. Corsinovi L., Bo M., Ricauda Aimonino N., et al. Predictors of falls and hospitalization outcomes in elderly patients admitted to an acute geriatric unit. Arch Gerontol Geriatr 2009, 49(1):142-145.
26. Formiga F., Lopez-Soto A., Duaso E., et al. Differences in the characteristics of elderly patients suffering from hip fracture due to falls according to place of residence. J Am Med Dir Assoc 2007, 8(8):533-537.
27. Buchner D.M., Larson E.B. Falls and fractures in patients with Alzheimer-type dementia. JAMA 1987, 257(11):1492-1495.
28. Lim K.D., Ng K.C., Ng S.K., et al. Falls amongst institutionalised psycho-geriatric patients. Singapore Med J 2001, 42(10):466-472.
29. Queneau P., Bannwarth B., Carpentier F., et al. Emergency department visits caused by adverse drug events: results of a French survey. Drug Saf 2007, 30(1):81-88.
30. Weiner D.K., Hanlon J.T., Studenski S.A. Effects of central nervous system polypharmacy on falls liability in community-dwelling elderly. Gerontology 1998, 44(4):217-221.
31. Lord S.R., Anstey K.J., Williams P., et al. Psychoactive medication use, sensori-motor function and falls in older women. Br J Clin Pharmacol 1995, 39(3):227-234.
32. Hanlon J.T., Boudreau R.M., Roumani Y.F., et al. Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study. J Gerontol A Biol Sci Med Sci 2009, 64(4):492-498.
33. Thapa P.B., Gideon P., Fought R.L., et al. Psychotropic drugs and risk of recurrent falls in ambulatory nursing home residents. Am J Epidemiol 1995, 142(2):202-211.
34. Le Couteur D.G., Fisher A.A., Davis M.W., et al. Postprandial systolic blood pressure responses of older people in residential care: association with risk of falling. Gerontology 2003, 49(4):260-264.
35. Aizenberg D., Sigler M., Weizman A., et al. Anticholinergic burden and the risk of falls among elderly psychiatric inpatients: a 4-year case-control study. Int Psychogeriatr 2002, 14(3):307-310.
36. Tinetti M.E., Speechley M., Ginter S.F. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988, 319(26):1701-1707.
37. Mion L.C., Gregor S., Buettner M., et al. Falls in the rehabilitation setting: incidence and characteristics. Rehabil Nurs 1989, 14(1):17-22.
38. Kallin K., Gustafson Y., Sandman P.O., et al. Drugs and falls in older people in geriatric care settings. Aging Clin Exp Res 2004, 16(4):270-276.
39. Ensrud K.E., Blackwell T.L., Mangione C.M., et al. Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc 2002, 50(10):1629-1637.
40. Wagner A.K., Ross-Degnan D., Gurwitz J.H., et al. Effect of New York State regulatory action on benzodiazepine prescribing and hip fracture rates. Ann Intern Med 2007, 146(2):96-103.
41. Briesacher B.A., Soumerai S.B., Field T.S., et al. Medicare part D's exclusion of benzodiazepines and fracture risk in nursing homes. Arch Intern Med 2010, 170(8):693-698.
42. Ray W.A., Griffin M.R., Downey W. Benzodiazepines of long and short elimination half-life and the risk of hip fracture. JAMA 1989, 262(23):3303-3307.
43. Cummings S.R., Nevitt M.C., Browner W.S., et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1995, 332(12):767-773.
44. Passaro A., Volpato S., Romagnoni F., et al. Benzodiazepines with different half-life and falling in a hospitalized population: the GIFA study. Gruppo Italiano di Farmacovigilanza nell'Anziano. J Clin Epidemiol 2000, 53(12):1222-1229.
45. Herings R.M., Stricker B.H., de Boer A., et al. Benzodiazepines and the risk of falling leading to femur fractures. Dosage more important than elimination half-life. Arch Intern Med 1995, 155(16):1801-1807.
46. Ray W.A., Thapa P.B., Gideon P. Benzodiazepines and the risk of falls in nursing home residents. J Am Geriatr Soc 2000, 48(6):682-685.
47. Neutel C.I., Perry S., Maxwell C., et al. Medication use and risk of falls. Pharmacoepidemiol Drug Saf 2002, 11(2):97-104.
48. Swift C.G., Swift M.R., Ankier S.I., et al. Single dose pharmacokinetics and pharmacodynamics of oral loprazolam in the elderly. Br J Clin Pharmacol 1985, 20(2):119-128.
49. Robin D.W., Hasan S.S., Edeki T., et al. Increased baseline sway contributes to increased losses of balance in older people following triazolam. J Am Geriatr Soc 1996, 44(3):300-304.
50. Robin D.W., Hasan S.S., Lichtenstein M.J., et al. Dose-related effect of triazolam on postural sway. Clin Pharmacol Ther 1991, 49(5):581-588.
51. Swift C.G., Ewen J.M., Clarke P., et al. Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations. Br J Clin Pharmacol 1985, 20(2):111-118.
52. Sorock G.S., Shimkin E.E. Benzodiazepine sedatives and the risk of falling in a community-dwelling elderly cohort. Arch Intern Med 1988, 148(11):2441-2444.
53. Iinattiniemi S., Jokelainen J., Luukinen H., et al. Falls risk among a very old home-dwelling population. Scand J Prim Health Care 2009, 27(1):25-30.
54. Formiga F., Navarro M., Duaso E., et al. Factors associated with hip fracture-related falls among patients with a history of recurrent falling. Bone 2008, 43(5):941-944.
55. Yip Y.B., Cumming R.G. The association between medications and falls in Australian nursing-home residents. Med J Aust 1994, 160(1):14-18.
56. Mustard C.A., Mayer T. Case-control study of exposure to medication and the risk of injurious falls requiring hospitalization among nursing home residents. Am J Epidemiol 1997, 145(8):738-745.
57. Horikawa E., Matsui T., Arai H., et al. Risk of falls in Alzheimer's disease: a prospective study. Intern Med 2005, 44(7):717-721.
58. Hien le T.T., Cumming R.G., Cameron I.D., et al. Atypical antipsychotic medications and risk of falls in residents of aged care facilities. J Am Geriatr Soc 2005, 53(8):1290-1295.
59. Katz I.R., Rupnow M., Kozma C., et al. Risperidone and falls in ambulatory nursing home residents with dementia and psychosis or agitation: secondary analysis of a double-blind, placebo-controlled trial. Am J Geriatr Psychiatry 2004, 12(5):499-508.
60. Liu Y.J., Stagni G., Walden J.G., et al. Thioridazine dose-related effects on biomechanical force platform measures of sway in young and old men. J Am Geriatr Soc 1998, 46(4):431-437.
61. Schneider L.S., Tariot P.N., Dagerman K.S., et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Engl J Med 2006, 355(15):1525-1538.
62. Schneider L.S., Dagerman K.S., Insel P., et al. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 2005, 294(15):1934-1943.
63. Ballard C., Hanney M.L., Theodoulou M., et al. The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial. Lancet Neurol 2009, 8(2):151-157.
64. Liu B.A., Topper A.K., Reeves R.A., et al. Falls among older people: relationship to medication use and orthostatic hypotension. J Am Geriatr Soc 1995, 43(10):1141-1145.
65. Kerse N., Flicker L., Pfaff J.J., et al. Falls, depression and antidepressants in later life: a large primary care appraisal. PLoS One 2008, 3(6):e2423.
66. Vassallo M., Sharma J.C., Allen S.C., et al. Characteristics of single fallers and recurrent fallers among hospital in-patients. Gerontology 2002, 48(3):147-150.
67. Aizen E., Shugaev I., Lenger R., et al. Risk factors and characteristics of falls during inpatient rehabilitation of elderly patients. Arch Gerontol Geriatr 2007, 44(1):1-12.
68. Granek E., Baker S.P., Abbey H., et al. Medications and diagnoses in relation to falls in a long-term care facility. J Am Geriatr Soc 1987, 35(6):503-511.
69. Kallin K., Lundin-Olsson L., Jensen J., et al. Predisposing and precipitating factors for falls among older people in residential care. Public Health 2002, 116(5):263-271.
70. Fonad E., Wahlin T.B., Winblad B., et al. Falls and fall risk among nursing home residents. J Clin Nurs 2008, 17(1):126-134.
71. Ray W.A., Griffin M.R., Malcolm E. Cyclic antidepressants and the risk of hip fracture. Arch Intern Med 1991, 151(4):754-756.
72. Thapa P.B., Gideon P., Cost T.W., et al. Antidepressants and the risk of falls among nursing home residents. N Engl J Med 1998, 339(13):875-882.
73. Diem S.J., Blackwell T.L., Stone K.L., et al. Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. Arch Intern Med 2007, 167(12):1240-1245.
74. Richards J.B., Papaioannou A., Adachi J.D., et al. Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Intern Med 2007, 167(2):188-194.
75. Draganich L.F., Zacny J., Klafta J., et al. The effects of antidepressants on obstructed and unobstructed gait in healthy elderly people. J Gerontol A Biol Sci Med Sci 2001, 56(1):M36-M41.
76. Laghrissi-Thode F., Pollock B.G., Miller M.C., et al. Double-blind comparison of paroxetine and nortriptyline on the postural stability of late-life depressed patients. Psychopharmacol Bull 1995, 31(4):659-663.
77. Paleacu D., Shutzman A., Giladi N., et al. Effects of pharmacological therapy on gait and cognitive function in depressed patients. Clin Neuropharmacol 2007, 30(2):63-71.
78. Draper B., Brodaty H., Low L.F., et al. Use of psychotropics in Sydney nursing homes: associations with depression, psychosis, and behavioral disturbances. Int Psychogeriatr 2001, 13(1):107-120.
79. Hollingworth S.A., Burgess P.M., Harvey A.W. Affective and anxiety disorders: prevalence, treatment and antidepressant medication use. Aust N Z J Psychiatry 2010, 44(6):513-519.
80. Nevitt M.C., Cummings S.R., Kidd S., et al. Risk factors for recurrent nonsyncopal falls. A prospective study. JAMA 1989, 261(18):2663-2668.
81. Hanlon J.T., Landerman L.R., Fillenbaum G.G., et al. Falls in African American and white community-dwelling elderly residents. J Gerontol A Biol Sci Med Sci 2002, 57(7):M473-M478.
82. Gerdhem P., Ringsberg K.A., Akesson K., et al. Clinical history and biologic age predicted falls better than objective functional tests. J Clin Epidemiol 2005, 58(3):226-232.
83. Cauley J.A., Cummings S.R., Seeley D.G., et al. Effects of thiazide diuretic therapy on bone mass, fractures, and falls. The Study of Osteoporotic Fractures Research Group. Ann Intern Med 1993, 118(9):666-673.
84. Schoofs M.W., van der Klift M., Hofman A., et al. Thiazide diuretics and the risk for hip fracture. Ann Intern Med 2003, 139(6):476-482.
85. Cumming R.G., Klineberg R.J. Psychotropics, thiazide diuretics and hip fractures in the elderly. Med J Aust 1993, 158(6):414-417.
86. Herings R.M., Stricker B.H., de Boer A., et al. Current use of thiazide diuretics and prevention of femur fractures. J Clin Epidemiol 1996, 49(1):115-119.
87. Lim L.S., Fink H.A., Blackwell T., et al. Loop diuretic use and rates of hip bone loss and risk of falls and fractures in older women. J Am Geriatr Soc 2009, 57(5):855-862.
88. Tromp A.M., Ooms M.E., Popp-Snijders C., et al. Predictors of fractures in elderly women. Osteoporos Int 2000, 11(2):134-140.
89. Tromp A.M., Smit J.H., Deeg D.J., et al. Predictors for falls and fractures in the Longitudinal Aging Study Amsterdam. J Bone Miner Res 1998, 13(12):1932-1939.
90. Walker P.C., Alrawi A., Mitchell J.F., et al. Medication use as a risk factor for falls among hospitalized elderly patients. Am J Health Syst Pharm 2005, 62(23):2495-2499.
91. Koski K., Luukinen H., Laippala P., et al. Physiological factors and medications as predictors of injurious falls by elderly people: a prospective population-based study. Age Ageing 1996, 25(1):29-38.
92. Gillespie L.D., Robertson M.C., Gillespie W.J., et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2009, (2). CD007146.
93. Campbell A.J., Robertson M.C., Gardner M.M., et al. Psychotropic medication withdrawal and a home-based exercise program to prevent falls: a randomized, controlled trial. J Am Geriatr Soc 1999, 47(7):850-853.
94. van der Velde N., Stricker B.H., Pols H.A., et al. Risk of falls after withdrawal of fall-risk-increasing drugs: a prospective cohort study. Br J Clin Pharmacol 2007, 63(2):232-237.
95. van der Velde N., Stricker B.H., Pols H.A., et al. Withdrawal of fall-risk-increasing drugs in older persons: effect on mobility test outcomes. Drugs Aging 2007, 24(8):691-699.
96. van der Velde N., van den Meiracker A.H., Pols H.A., et al. Withdrawal of fall-risk-increasing drugs in older persons: effect on tilt-table test outcomes. J Am Geriatr Soc 2007, 55(5):734-739.
97. Alsop K., Mac Mahon M. Withdrawing cardiovascular medications at a syncope clinic. Postgrad Med J 2001, 77(908):403-405.
98. Zermansky A.G., Alldred D.P., Petty D.R., et al. Clinical medication review by a pharmacist of elderly people living in care homes-randomised controlled trial. Age Ageing 2006, 35(6):586-591.
99. Haumschild M.J., Karfonta T.L., Haumschild M.S., et al. Clinical and economic outcomes of a fall-focused pharmaceutical intervention program. Am J Health Syst Pharm 2003, 60(10):1029-1032.
100. Weber V., White A., Mcilvried R., et al. An electronic medical record (EMR)-based intervention to reduce polypharmacy and falls in an ambulatory rural elderly population. J Gen Intern Med 2008, 23(4):399-404.
101. Peterson J.F., Kuperman G.J., Shek C., et al. Guided prescription of psychotropic medications for geriatric inpatients. Arch Intern Med 2005, 165(7):802-807.
102. Pit S.W., Byles J.E., Henry D.A., et al. A quality use of medicines program for general practitioners and older people: a cluster randomised controlled trial. Med J Aust 2007, 187(1):23-30.
103. Krauss M.J., Tutlam N., Costantinou E., et al. Intervention to prevent falls on the medical service in a teaching hospital. Infect Control Hosp Epidemiol 2008, 29(6):539-545.
104. Ray W.A., Taylor J.A., Brown A.K., et al. Prevention of fall-related injuries in long-term care: a randomized controlled trial of staff education. Arch Intern Med 2005, 165(19):2293-2298.
105. Whitehead C., Wundke R., Crotty M., et al. Evidence-based clinical practice in falls prevention: a randomised controlled trial of a falls prevention service. Aust Health Rev 2003, 26(3):88-97.
106. Colon-Emeric C., Schenck A., Gorospe J., et al. Translating evidence-based falls prevention into clinical practice in nursing facilities: results and lessons from a quality improvement collaborative. J Am Geriatr Soc 2006, 54(9):1414-1418.
107. Chou W.C., Tinetti M.E., King M.B., et al. Perceptions of physicians on the barriers and facilitators to integrating fall risk evaluation and management into practice. J Gen Intern Med 2006, 21(2):117-122.
108. Tinetti M.E., Mcavay G.J., Fried T.R., et al. Health outcome priorities among competing cardiovascular, fall injury, and medication-related symptom outcomes. J Am Geriatr Soc 2008, 56(8):1409-1416.
109. Whitehead C.H., Wundke R., Crotty M., et al. Attitudes to falls and injury prevention: what are the barriers to implementing falls prevention strategies?. Clin Rehabil 2006, 20(6):536-542.
110. Perry B.C. Falls among the elderly living in high-rise apartments. J Fam Pract 1982, 14(6):1069-1073.
111. Hale W.A., Delaney M.J., Mcgaghie W.C. Characteristics and predictors of falls in elderly patients. J Fam Pract 1992, 34(5):577-581.
112. O'Loughlin J.L., Robitaille Y., Boivin J.F., et al. Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly. Am J Epidemiol 1993, 137(3):342-354.
113. Maki B.E., Holliday P.J., Topper A.K. A prospective study of postural balance and risk of falling in an ambulatory and independent elderly population. J Gerontol 1994, 49(2):M72-M84.
114. Mahoney J., Sager M., Dunham N.C., et al. Risk of falls after hospital discharge. J Am Geriatr Soc 1994, 42(3):269-274.
115. Ensrud K.E., Blackwell T., Mangione C.M., et al. Central nervous system active medications and risk for fractures in older women. Arch Intern Med 2003, 163(8):949-957.
116. Chu L.W., Chi I., Chiu A.Y., et al. Incidence and predictors of falls in the Chinese elderly. Ann Acad Med Singapore 2005, 34(1):60-72.