Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation

Journal of Controlled Release

Volumn 135, Issue 1, 2009, Pages 11-18

  Takemoto, Seiji ^a   Nishikawa, Makiya ^a   Otsuki, Takayuki ^a   Yamaoka, Ayumi ^a   Maeda, Kazuki ^a   Ota, Atsushi ^a   Takakura, Yoshinobu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

CTL; Cytosolic delivery; Hsp70; MHC class I presentation; Protein vaccine

Indexed keywords

ANTI-TUMOR ACTIVITIES; ANTIGEN DELIVERY SYSTEMS; CTL; CYTOSOL; CYTOSOLIC DELIVERY; CYTOTOXIC T LYMPHOCYTES; DENDRITIC CELLS; E. COLI; FUSION PROTEINS; HEAT-SHOCK PROTEIN 70; HSP70; MHC CLASS I PRESENTATION; OVALBUMIN; POLYHISTIDINE; RECEPTOR-MEDIATED ENDOCYTOSIS;

AMINES; CELL CULTURE; DENDRIMERS; ESCHERICHIA COLI; PROTEINS;

ANTIGENS;

ANTINEOPLASTIC AGENT; HEAT SHOCK PROTEIN 70 PLUS SERYLISOLEUCYLISOLEUCYLASPARAGINYLPHENYLALANYLGLUTAMYLLYSYLLEUCINESERYL ISOLEUCYLISOLEUCYLASPARAGINYLPHENYLALANYLGLUTAMYLLYSYLLEUCINE FUSION PROTEIN; HEAT SHOCK PROTEIN 70 PLUS SERYLISOLEUCYLISOLEUCYLASPARAGINYLPHENYLALANYLGLUTAMYLLYSYLLEUCINESERYL ISOLEUCYLISOLEUCYLASPARAGINYLPHENYLALANYLGLUTAMYLLYSYLLEUCINE PLUS POLYHISTIDINE FUSION PROTEIN; PLASMID VECTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNIZATION; CELLULAR IMMUNITY; CONJUGATION; CONTROLLED STUDY; CYTOSOL; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG UPTAKE; ENDOCYTOSIS; ESCHERICHIA COLI; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T CELL LYMPHOMA;

ANIMALS; ANTIGEN PRESENTATION; CELL LINE, TUMOR; CELL SURVIVAL; CYTOSOL; DENDRITIC CELLS; DRUG DELIVERY SYSTEMS; EPITOPES; ESCHERICHIA COLI; FEMALE; HISTIDINE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HSC70 HEAT-SHOCK PROTEINS; INTERLEUKIN-2; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; NEOPLASMS; OVALBUMIN; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 61649083498     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.11.024     Document Type: Article

References (36)

1. Ke Y., Li Y., and Kapp J.A. Ovalbumin injected with complete Freund's adjuvant stimulates cytolytic responses. Eur. J. Immunol. 25 (1995) 549-553
2. Moron G., Dadaglio G., and Leclerc C. New tools for antigen delivery to the MHC class I pathway. Trends Immunol. 25 (2004) 92-97
3. Bukau B., and Horwich A.L. The Hsp70 and Hsp60 chaperone machines. Cell 92 (1995) 351-366
4. Hartl F.U. Molecular chaperones in cellular protein folding. Nature 381 (1996) 571-579
5. Ueda G., Tamura Y., Hirai I., Kamiguchi K., Ichimiya S., Torigoe T., Hiratsuka H., Sunakawa H., and Sato N. Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity. Cancer Sci. 95 (2004) 248-253
6. Moroi Y., Mayhew M., Trcka J., Hoe M.H., Takechi Y., Hartl F.U., Rothman J.E., and Houghton A.N. Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70. Proc. Natl. Acad. Sci. U S A 97 (2000) 3485-3490
7. Binder R.J., Han D.K., and Srivastava P.K. CD91: a receptor for heat shock protein gp96. Nat. Immunol. 1 (2000) 151-155
8. Delneste Y., Magistrelli G., Gauchat J., Haeuw J., Aubry J., Nakamura K., Kawakami-Honda N., et al. Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity 17 (2002) 353-362
9. Takemoto S., Nishikawa M., and Takakura Y. Pharmacokinetics and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice. Pharm. Res. 22 (2005) 419-426
10. Udono H., and Srivastava P.K. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70. J. Immunol. 152 (1994) 5398-5403
11. Srivastava P.K. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu. Rev. Immunol. 20 (2002) 395-425
12. Somersan S., Larsson M., Fonteneau J.F., Basu S., Srivastava P.K., and Bhardwaj N. Primary tumor tissue lysates are enriched in heat shock proteins and induce the maturation of human dendritic cells. J. Immunol. 167 (2001) 4844-4852
13. Gullo C.A., and Teoh G. Heat shock proteins: to present or not, that is the question. Immunol. Lett. 94 (2004) 1-10
14. Castellino F., Boucher P.E., Eichelberg K., Mayhew M., Rothman J.E., Houghton A.N., and Germain R.N. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J. Exp. Med. 191 (2000) 1957-1964
15. Laus R., Graddis T.J., Hakim I., and Vidovic D. Enhanced major histocompatibility complex class I-dependent presentation of antigens modified with cationic and fusogenic peptides. Nat. Biotech. 18 (2000) 1269-1272
16. Putnam D., Gentry C.A., Pack D.W., and Langer R. Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini. Proc. Natl. Acad. Sci. U S A 98 (2001) 1200-1205
17. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., and Behr J.P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U S A 92 (1995) 7297-7301
18. Pecheur E.I., Sainte-Marie J., Bienvenue A., and Hoekstra D. Peptide and membrane fusion: towards an understanding of the molecular mechanism of protein-induced fusion. J. Membr. Biol. 167 (1999) 1-17
19. Plank C., Oberhauser B., Mechtler K., Koch C., and Wagner E. The influence of endosome-distruptive peptides on gene transfer using synthetic virus-like gene transfer system. J. Biol. Chem. 269 (1994) 12918-12924
20. Pfeifer J.D., Wick M.J., Roberts R.L., Findlay K., Normark S.J., and Harding C.V. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature 361 (1993) 359-362
21. Moore M.W., Carbone F.R., and Bevan M.J. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54 (1998) 777-785
22. Udono H., Yamano T., Kawabata Y., Ueda M., and Yui K. Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70. Int. Immunol. 13 (2001) 1233-1242
23. Mo A.X., Lelyveld S.F., Craiu A., and Rock K.L. Sequences that flank subdominant and cryptic epitopes influence the proteolytic generation of MHC class I-presented peptides. J. Immunol. 164 (2000) 4003-4010
24. Hnatowich D.J., Layne W.W., and Childs R.L. The preparation and labeling of DTPA-coupled albumin. Int. J. Appl. Radiat. Isot. 33 (1982) 327-332
25. Shakushiro K., Yamasaki Y., Nishikawa M., and Takakura Y. Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells. Immunology 112 (2004) 211-218
26. Supino R. MTT assays. Methods Mol. Biol. 43 (1995) 137-149
27. Duncan J.R., and Welch M.J. Intracellular metabolism of indium-111-DTPA-labeled receptor targeted proteins. J. Nucl. Med. 34 (1993) 1728-1738
28. Rock K.L., Gram C., Rothstein L., Clark K., Stein R., Dick L., Hwang D., and Goldberg A.L. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78 (1994) 761-771
29. Shen Z., Reznikoff G., Dranoff G., and Rock K.L. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. J. Immunol. 158 (1997) 2723-2730
30. Moron V.G., Rueda P., Sedlik C., and Leclerc C. In vivo, dendritic cells can cross-present virus-like particles using an endosome-to-cytosol pathway. J. Immunol. 171 (2003) 2242-2250
31. Fischer D., Li Y., Ahlermeyer B., Krieglstein J., and Kissel T. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 24 (2003) 1121-1131
32. Suzue K., Zhou X., Eisen H.N., and Young R.A. Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proc. Natl. Acad. Sci. USA 94 (1997) 13146-13151
33. Mandal M., and Lee K.D. Lysteriolysin O-liposome-mediated cytosolic delivery of macromolecule antigen in vivo: enhancement of antigen-specific cytotoxic T lymphocyte frequency, activity, and tumor protection. Biochim. Biophys. Acta 1563 (2002) 7-17
34. Shen L., Sigal L.J., Boes M., and Rock K.L. Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity 21 (2004) 155-165
35. Wick M.J., and Pfeifer J.D. Major histocompatibility complex class I presentation of ovalbumin peptide 257-264 from exogenous sources: protein context influences the degree of TAP-independent presentation. Eur. J. Immunol. 26 (1996) 2790-2799
36. Liu L., Zhou X., Liu H., Xiang L., and Yuan Z. CpG motif acts as a 'danger signal' and provides a T helper type 1-biased microenvironment for DNA vaccination. Immunology 115 (2005) 223-230