Intra-arterial infusion of leptin does not affect blood pressure in salt-loaded rabbits

Pakistan Journal of Biological Sciences

Volumn 13, Issue 15, 2010, Pages 761-764

  Mohammad, Mukhallad A ^a   Talafih, Khalid ^a   Mohamad, Mohamad M J ^a   Khabaz, Mohammad Nidal ^a  

^a JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

Author keywords

Blood pressure; Cardiovascular system; High salt diet; Leptin; Sympathetic activity

Indexed keywords

LEPTIN;

ANIMAL; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; DRUG EFFECT; FEMALE; INTRAARTERIAL DRUG ADMINISTRATION; MALE; RABBIT; SALT INTAKE; SODIUM RESTRICTION;

ANIMALS; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; DIET, SODIUM-RESTRICTED; FEMALE; INFUSIONS, INTRA-ARTERIAL; LEPTIN; MALE; RABBITS; SODIUM CHLORIDE, DIETARY;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 77957679227     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2010.761.764     Document Type: Article

References (20)

1. Beltowski, J., 2006. Leptin and atherosclerosis. Atherosclerosis, 189: 47-60.
2. Collins, S., CM. Kuhn, A.E. Petro, A.G. Swick, B. A. Chrunyk and R. S. Surwit, 1996. Role of leptin in fat regulation. Nature, 380: 677-677.
3. Dunbar, J.C., Y. Hu and H. Lu, 1997. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes, 46: 2040-2043.
4. Fruhbeck, G., 1999. Pivotal role of nitric oxide in the control of blood pressure after leptin administration. Diabetes, 48: 903-908.
5. Jackson, E.K. and P. Li, 1997. Human leptin has natriuretic activity in the rat. Am. J. Physiol, 272: 333-338.
6. Jaffar, M.M., D.S. Myers, L.J. Hainsworth, R. Hainsworth and M.J. Dnnkhill, 2005. Effect of dietary salt loading on the responses of isolated rat mesenteric arteries to leptin. Am. J. Hypertension, 18: 500-503.
7. Kimura, K., K. Tsuda, A. Baba, T. Kawabe and S. Boh-okax /xet-aletal/et-al, 2000. Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin. Biochem. Biophys. Res. Commun., 273: 745-749.
8. Lembo, G., C. Vecchione, L. Fratta, G. Marino, V. Trimarco, G. d'Amati and B. Trimarco, 2000. Leptin induces direct vasodilation through distinct endothelial mechanisms. Diabetes, 49: 293-297.
9. Matsuda, K., H. Teragawa, Y. Fukuda, K. Nakagawa, Y. Higashi and K. Chayama, 2003. Leptin causes nitric-oxide independent coronary artery vasodilation in humans. Hypertension Res., 26: 147-152.
10. Mitchell, J.L., D.A. Morgan, M.L. Correia, A.L. Mark, W.I. Sivitz and W.G. Haynes, 2001. Does leptin stimulate nitric oxide to oppose the effect of sympathetic activation? Hypertension, 38: 1081-1086.
11. Mohammed, M.M., D.S. Myers, O.A. Sofola, R. Hainsworth and M.J. Drinkhill, 2007. Vasodilator effects of leptin on canine isolated mesenteric arteries and veins. Clin. Exp. Pharm. Physiol., 34: 771-774.
12. Mohamad, M.M.J., M.A. Mohammad, K.S.H. Alomari, M. Karayyem and A.F. Al-Hader, 2009. Leptin, insulin and glucose levels in Menopause women during acute myocardial infarction. J. Med. Sci., 9: 214-218.
13. Nakagawa, K., Y. Higashi, S. Sasaki, T. Oshima, H. Matsuura and K. Chayama, 2002. Leptin causes vasodilatation in human. Hypertension Res., 25: 161-165.
14. Rahmouni, K. and W.G. Haynes, 2004. Leptin and the cardiovascular system. Recent Prog. Horm. Res., 59: 225-244.
15. Salahdeen, H.M. and A.R.A. Alada, 2007. Cardiovascular response to angiotensin II and captopril in normal and diabetic rats loaded with salt. J. Medical Sci., 7: 187-194.
16. Shek, E.W., M.W. Brands and J.E. Hall, 1998. Chronic leptin infusion increases arterial pressure. Hypertension, 31: 409-414.
17. Sieira-Honigmann, M.R., A.K. Nath, C. Murakami, G. Garcia-Cardena and A. Papapetropoulos et al., 1998. Biological action of leptin as an angiogenic factor. Science, 281: 1683-1686.
18. Villarreal, D., G. Reams, R.H. Freeman and A. Taraben, 1998. Renal effects of leptin in normotensive, hypertensive and obese rats. Am. J. Physiol., 275: R2056-R2060.
19. Talafih, K.F., M.J. Mohamad, M.A. Mohammad and Z.J. El-Akawi, 2009. Effect of intra-venous versus intra-arterial leptin infusion on blood pressure and heart rate. Open Physiol. J., 2: 14-17.
20. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold and J.M. Friedman, 1994. Positional cloning of the mouse obese gene and its human homologue. Nature, 372: 425-432.