A simple, sensitive high-performance liquid chromatography -ultraviolet method for the quantification of concentration and steady-state pharmacokinetics of itraconazole and hydroxyitraconazole

Annals of Clinical Biochemistry

Volumn 47, Issue 5, 2010, Pages 432-439

  Miura, M ^a   Takahashi, N ^b   Nara, M ^b   Fujishima, N ^a   Kagaya, H ^a   Kameoka, Y ^b   Saitoh, H ^b   Tagawa, H ^b   Sawada, K ^b  

^a AKITA UNIVERSITY HOSPITAL   (Japan)

^b AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYITRACONAZOLE; ITRACONAZOLE;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LOADING DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SOLID PHASE EXTRACTION; STEADY STATE; ULTRAVIOLET RADIATION;

BLOOD CHEMICAL ANALYSIS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; ITRACONAZOLE; SOLID PHASE EXTRACTION; ULTRAVIOLET RAYS;

EID: 77957672468     PISSN: 00045632     EISSN: 00045632     Source Type: Journal    
DOI: 10.1258/acb.2010.010029     Document Type: Article

References (24)

1. De Beule K, Van Gestel J. Pharmacology of itraconazole. Drugs 2001;61(Suppl. 1):27-37
2. Van Cutsem J. The in vitro antifungal spectrum of itraconazole. Mycoses 1989;32(Suppl. 1):7-13
3. Poirier JM, Cheymol G. Optimization of itraconazole therapy using target drug concentrations. Clin Pharmacokinet 1998;35:461-73 (Pubitemid 29010176)
4. Heykants J, Van Peer A, Van de Velde V, et al. The clinical pharmacokinetics of itraconazole: an overview. Mycoses 1989;32:67-87
5. Isoherranen N, Kunze KL, Allen KE, Nelson WL, Thummel KE. Role of itraconazole metabolites in CYP3A4 inhibition. Drug Metab Dispos 2004;32:1121-31 (Pubitemid 39287586)
6. Haria M, Bryson HM, Goa KL. Itraconazole. A reappraisal of its pharmacological properties and therapeutic use in the management of superficial fungal infections. Drugs 1996;51:585-620
7. Espinel-Ingroff A, Johnson E, Hockey H, Troke P. Activities of voriconazole, itraconazole and amphotericin B in vitro against 590 moulds from 323 patients in the voriconazole Phase III clinical studies. J Antimicrob Chemother 2008;61:616-20 (Pubitemid 351321136)
8. Rex JH, Pfaller MA, Galgiani JN, et al. Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and Candida infections. Subcommittee on Antifungal Susceptibility Testing of the National Committee for Clinical Laboratory Standards. Clin Infect Dis 1997;24:235-47
9. Barone JA, Moskovitz BL, Guarnieri J, et al. Enhanced bioavailability of itraconazole in hydroxypropyl-beta-cyclodextrin solution versus capsules in healthy volunteers. Antimicrob Agents Chemother 1998;42:1862-5 (Pubitemid 28311595)
10. Cartledge JD, Midgely J, Gazzard BG. Itraconazole solution: higher serum drug concentrations and better clinical response rates than the capsule formulation in acquired immunodeficiency syndrome patients with candidosis. J Clin Pathol 1997;50:477-80 (Pubitemid 27315993)
11. Jia JY, Lu C, Liu GY, et al. Simultaneous determination of itraconazole and hydroxyitraconazole in human plasma by liquid chromatography-isotope dilution tandem mass spectrometry method. Biomed Chromatogr 2010;24:648-54
12. Bharathi DV, Hotha KK, Sagar PV, et al. Development and validation of a highly sensitive and robust LC-MS/MS with electrospray ionization method for simultaneous quantitation of itraconazole and hydroxyitraconazole in human plasma: application to a bioequivalence study. J Chromatogr B 2008;868:70-6
13. Kousoulos C, Tsatsou G, Apostolou C, Dotsikas Y, Loukas YL. Development of a high-throughput method for the determination of itraconazole and its hydroxy metabolite in human plasma, employing automated liquid-liquid extraction based on 96-well format plates and LC/MS/MS. Anal Bioanal Chem 2006;384:199-207 (Pubitemid 41817858)
14. Vogeser M, Spöhrer U, Schiel X. Determination of itraconazole and hydroxyitraconazole in plasma by use of liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction. Clin Chem Lab Med 2003;41:915-20 (Pubitemid 37010185)
15. Carrier A, Parent J. Liquid chromatographic-mass spectrometric determination of itraconazole and its major metabolite, hydroxyitraconazole, in dog plasma. J Chromatogr B 2000;745:413-20 (Pubitemid 30665565)
16. Uno T, Shimizu M, Sugawara K, Tateishi T. Sensitive determination of itraconazole and its active metabolite in human plasma by column-switching high-performance liquid chromatography with ultraviolet detection. Ther Drug Monit 2006;28:526-31 (Pubitemid 44181486)
17. Abdel-Rahman SM, Jacobs RF, Massarella J, et al. Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescents. Antimicrob Agents Chemother 2007;51:2668-73 (Pubitemid 47206198)
18. Ohkubo T, Osanai T. Determination of itraconazole in human plasma by high-performance liquid chromatography with solid-phase extraction. Ann Clin Biochem 2005;42(Part 2):94-8 (Pubitemid 40516138)
19. Cociglio M, Hillaire-Buys D, Alric R. Prevalidation statistical design to assess analytical methods. Example of a quick liquid chromatographic assay of itraconazole in serum. J Chromatogr B 1997;698:225-33 (Pubitemid 27412525)
20. Shah VP, Midha KK, Findlay JW, et al. Bioanalytical method validation-a revisit with a decade of progress. Pharm Res 2000;17:1551-7
21. Barone JA, Koh JG, Bierman RH, et al. Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy male volunteers. Antimicrob Agents Chemother 1993;37:778-84
22. Stevens DA. Itraconazole in cyclodextrin solution. Pharmacotherapy 1999;19:603-11
23. Timmers GJ, Kessels LW, Wilhelm AJ, et al. Effects of cyclosporine A on single-dose pharmacokinetics of intravenous itraconazole in patients with hematologic malignancies. Ther Drug Monit 2008;30:301-5
24. Mori T, Aisa Y, Kato J, et al. Drug interaction between oral solution itraconazole and calcineurin inhibitors in allogeneic hematopoietic stem cell transplantation recipients: an association with bioavailability of oral solution itraconazole. Int J Hematol 2009;90:103-7