Drug interaction between oral solution itraconazole and calcineurin inhibitors in allogeneic hematopoietic stem cell transplantation recipients: An association with bioavailability of oral solution itraconazole

International Journal of Hematology

Volumn 90, Issue 1, 2009, Pages 103-107

  Mori, Takehiko ^a   Aisa, Yoshinobu ^a   Kato, Jun ^a   Nakamura, Yukinori ^a   Ikeda, Yasuo ^a   Okamoto, Shinichiro ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcineurin inhibitors; Drug interaction; Hematopoietic stem cell transplantation; Oral solution itraconazole

Indexed keywords

CYCLOSPORIN A; HYDROXYITRACONAZOLE; ITRACONAZOLE; TACROLIMUS;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFECT; DRUG POTENTIATION; HUMAN;

ADMINISTRATION, ORAL; ANTIFUNGAL AGENTS; CALCINEURIN; CYCLOSPORINE; DRUG INTERACTIONS; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ITRACONAZOLE; MALE; RETROSPECTIVE STUDIES; TACROLIMUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 70350570566     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-009-0344-z     Document Type: Article

References (27)

1. CA Dykewicz HW Jaffe 2006 Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients Biol Blood Marrow Transplant 6 670 672
2. KA Marr RA Carter F Crippa A Wald L Corey 2002 Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients Clin Infect Dis 34 909 917 10.1086/339202 11880955 10.1086/339202 (Pubitemid 34229758)
3. M Kami U Machida K Okuzumi T Matsumura S Mori Si A Hori, et al. 2002 Effect of fluconazole prophylaxis on fungal blood cultures: an autopsy-based study involving 720 patients with haematological malignancy Br J Haematol 117 40 46 10.1046/j.1365-2141.2002.03414.x 11918531 10.1046/j.1365-2141.2002.03414.x 1:CAS:528:DC%2BD38XjvFGlsL8%3D (Pubitemid 34304419)
4. DJ Winston RT Maziarz PH Chandrasekar HM Lazarus M Goldman JL Blumer, et al. 2003 Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. A multicenter, randomized trial Ann Intern Med 138 705 713 12729424 1:CAS:528:DC%2BD3sXktVyhsLg%3D
5. KA Marr F Crippa W Leisenring M Hoyle M Boeckh SA Balajee, et al. 2004 Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants Blood 103 1527 1533 10.1182/blood-2003-08-2644 14525770 10.1182/blood-2003-08-2644 1:CAS:528:DC%2BD2cXhsVSlu7k%3D (Pubitemid 38168674)
6. Y Ito K Ohyashiki I Yoshida M Takeuchi Y Aoyama A Mugitani, et al. 2007 The prophylactic effect of itraconazole capsules and fluconazole capsules for systemic fungal infections in patients with acute myeloid leukemia and myelodysplastic syndromes: a Japanese multicenter randomized, controlled study Int J Hematol 85 121 127 10.1532/IJH97.06079 17321989 10.1532/IJH97.06079 1:CAS:528:DC%2BD2sXjvV2rtL4%3D (Pubitemid 46365548)
7. AH Saad DD DePestel PL Carver 2006 Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants Pharmacotherapy 26 1730 1744 10.1592/phco.26.12.1730 17125435 10.1592/phco.26.12.1730 1:CAS:528:DC%2BD2sXislCmuw%3D%3D (Pubitemid 44885328)
8. CB Mahnke RM Sutton R Venkataramanan M Michaels G Kurland GJ Boyle, et al. 2003 Tacrolimus dosage requirements after initiation of azole antifungal therapy in pediatric thoracic organ transplantation Pediatr Transplant 7 474 478 10.1046/j.1397-3142.2003.00103.x 14870897 10.1046/j.1397-3142.2003.00103.x 1:CAS:528:DC%2BD3sXhtVSqtLjL (Pubitemid 37466209)
9. H Leather RM Boyette L Tian JR Wingard 2006 Pharmacokinetic evaluation of the drug interaction between intravenous itraconazole and intravenous tacrolimus or intravenous cyclosporin A in allogeneic hematopoietic stem cell transplant recipients Biol Bone Marrow Transplant 12 325 334 10.1016/j.bbmt.2005.10.022 10.1016/j.bbmt.2005.10.022 1:CAS:528: DC%2BD28XjslOqsL4%3D (Pubitemid 43273718)
10. T Uno M Shimizu K Sugawara T Tateishi 2006 Sensitive determination of itraconazole and its active metabolite in human plasma by column-switching high-performance liquid chromatography with ultraviolet detection Ther Drug Monit 28 526 531 10.1097/00007691-200608000-00007 16885720 10.1097/00007691- 200608000-00007 1:CAS:528:DC%2BD28XnslGksrs%3D (Pubitemid 44181486)
11. Y Kanbayashi K Nomura Y Fujimoto K Shimura D Shimizu K Okamoto, et al. 2008 Population pharmacokinetics of itraconazole solution used as prophylaxis for febrile neutropenia Int J Antimicrob Agents 31 452 457 10.1016/j. ijantimicag.2007.12.017 18359202 10.1016/j.ijantimicag.2007.12.017 1:CAS:528:DC%2BD1cXkvVOktro%3D
12. JTC Kwan PJD Foxall DGC Davidson MR Bending AJ Eisinger 1987 Interaction of cyclosporin and itraconazole Lancet 2 282 10.1016/S0140-6736(87)90873-7 2886752 10.1016/S0140-6736(87)90873-7 1:STN:280:DyaL2s3osFyltw%3D%3D
13. MR Kramer SE Marshall DW Denning AM Keogh RM Tucker JN Galgiani, et al. 1990 Cyclosporine and itraconazole interaction in heart and lung transplant recipients Ann Intern Med 113 327 329 2165371 1:STN:280:DyaK3czivVGltw%3D%3D
14. MR Kramer G Merin E Rudis I Bar T Nesher M Bublil, et al. 1997 Dose adjustment and cost of itraconazole prophylaxis in lung transplant recipients receiving cyclosporine and tacrolimus (FK 506) Transplant Proc 29 2657 2659 10.1016/S0041-1345(97)00546-0 9290780 10.1016/S0041-1345(97)00546-0 1:STN:280:DyaK2svjs1WisQ%3D%3D (Pubitemid 27383004)
15. EM Billaud R Guillemain F Tacco P Chevalier 1998 Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients Br J Clin Pharmacol 46 271 272 10.1046/j.1365-2125.1998. 00784.x 9764970 10.1046/j.1365-2125.1998.00784.x 1:CAS:528:DyaK1cXmtFKmtb8%3D (Pubitemid 28404842)
16. D Capone A Gentile P Imperatore G Palmiero V Basile 1999 Effects of itraconazole on tacrolimus blood concentrations in a renal transplant recipient Ann Pharmacother 33 1124 1125 10.1345/aph.18409 10534229 10.1345/aph.18409 1:STN:280:DC%2BD3c%2FgtFOqtA%3D%3D (Pubitemid 29489998)
17. R Banerjee N Leaver H Lyster NR Banner 2001 Coadministration of itraconazole and tacrolimus after thoracic organ transplantation Transplant Proc 33 1600 1602 11267435 10.1016/S0041-1345(00)02608-7 1:CAS:528: DC%2BD3MXitV2msLo%3D (Pubitemid 32237988)
18. MJ Cervelli GR Russ 2003 Itraconazole-tacrolimus drug interaction Ther Drug Monit 25 483 484 10.1097/00007691-200308000-00012 12883234 10.1097/00007691-200308000-00012 (Pubitemid 36927982)
19. Prentice AG, Glasmacher A. Making sense of itraconazole pharmacokinetics. J Antimicrob Chemother. 2005;56(Suppl S1):i17-22.
20. CR Bradford AG Prentice DW Warnock JA Copplestone 1991 Comparison of the multiple dose pharmacokinetics of two formulations of itraconazole during remission induction for acute myeloblastic leukaemia J Antimicrob Chemother 28 555 560 10.1093/jac/28.4.555 1662191 10.1093/jac/28.4.555 1:STN:280: DyaK387gsVyksQ%3D%3D
21. AG Prentice DW Warnock 1996 Itraconazole more bioavailable in solution Blood 88 3662 3663 8896437 1:CAS:528:DyaK28XmsFOns7o%3D
22. M Potter JP Donnelly 2004 The role of itraconazole in preventing and treating systemic fungal infections in immunocompromised patients Acta Haematol Acta Haematol 111 175 180 1:CAS:528:DC%2BD2cXitlyitbk%3D
23. MA Boogaerts GE Verhoef P Zachee H Demuynck L Verbist K De Beule 1989 Antifungal prophylaxis with itraconazole in prolonged neutropenia: correlation with plasma levels Mycoses 32 Suppl 1 103 108 2561181
24. G Tricot E Joosten MA Boogaerts J Vande Pitte G Cauwenbergh 1989 Ketoconazole vs. itraconazole for antifungal prophylaxis in patients with severe granulocytopenia: preliminary results of two nonrandomized studies Rev Infect Dis 9 Suppl 1 S94 S99
25. British Society for Antimicrobial Chemotherapy Working Party 1991 Laboratory monitoring of antifungal chemotherapy Lancet 337 1577 1580
26. AG Prentice DW Warnock SA Johnson MJ Phillips DA Oliver 1994 Multiple-dose pharmacokinetics of an oral solution of itraconazole in autologous bone marrow transplant recipients J Antimicrob Chemother 34 247 252 10.1093/jac/34.2.247 7814285 10.1093/jac/34.2.247 1:STN:280:DyaK2M7htlOhsQ%3D%3D
27. AP Grigg M Brown AW Roberts J Szer MA Slavin 2004 A pilot study of targeted itraconazole prophylaxis in patients with graft-versus-host disease at high risk of invasive mould infections following allogeneic stem cell transplantation Bone Marrow Transplant 34 447 453 10.1038/sj.bmt.1704614 15247932 10.1038/sj.bmt.1704614 1:CAS:528:DC%2BD2cXms1Cgtr8%3D (Pubitemid 39232375)