Development of a high-throughput method for the determination of itraconazole and its hydroxy metabolite in human plasma, employing automated liquid-liquid extraction based on 96-well format plates and LC/MS/MS

Analytical and Bioanalytical Chemistry

Volumn 384, Issue 1, 2006, Pages 199-207

  Kousoulos, Constantinos ^a   Tsatsou, Georgia ^a   Apostolou, Constantinos ^a   Dotsikas, Yannis ^a   Loukas, Yannis L ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

96 Well; Bioequivalence; Itraconazole; Mass spectrometry

Indexed keywords

96-WELL; BIOEQUIVALENCE; HUMAN PLASMA; ITRACONAZOLE; MULTIPLE REACTIONS MONITORING (MRM);

BIOASSAY; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PLASMAS; THROUGHPUT;

DRUG PRODUCTS;

ITRACONAZOLE;

ARTICLE; BLOOD; CHEMISTRY; HUMAN; HYDROXYLATION; LIQUID CHROMATOGRAPHY; METHODOLOGY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; HUMANS; HYDROXYLATION; ITRACONAZOLE; TANDEM MASS SPECTROMETRY;

EID: 29144474119     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-005-0159-6     Document Type: Article

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