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Volumn 228, Issue 1, 2010, Pages 1-9

Investigation of the performance of fermentation processes using a mathematical model including effects of metabolic bottleneck and toxic product on cells

Author keywords

Bottleneck enzyme; Ethanol fermentation; Logarithmic gain; Mathematical model; Product inhibition; S system representation

Indexed keywords

BOTTLENECK ENZYME; ETHANOL FERMENTATION; LOGARITHMIC GAIN; PRODUCT INHIBITION; S-SYSTEMS;

EID: 77957665198     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mbs.2010.08.001     Document Type: Article
Times cited : (11)

References (41)
  • 1
    • 0034985361 scopus 로고    scopus 로고
    • Ethanol production from biomass: technology and commercialization status
    • Mielenz J.R. Ethanol production from biomass: technology and commercialization status. Curr. Opin. Microbiol. 2001, 4:324.
    • (2001) Curr. Opin. Microbiol. , vol.4 , pp. 324
    • Mielenz, J.R.1
  • 2
    • 0026073604 scopus 로고
    • Relationship between fermentation capability and fatty acid composition of free and immobilized Saccharomyces cerevisiae
    • Hilge-Rotmann B., Rehm H.-J. Relationship between fermentation capability and fatty acid composition of free and immobilized Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 1991, 34:502.
    • (1991) Appl. Microbiol. Biotechnol. , vol.34 , pp. 502
    • Hilge-Rotmann, B.1    Rehm, H.-J.2
  • 4
    • 0037572330 scopus 로고    scopus 로고
    • Experimental investigations of multiple steady-states in aerobic continuous cultivations of Saccharomyces cerevisiae
    • Lei F., Olsson L., Jorgensen S.B. Experimental investigations of multiple steady-states in aerobic continuous cultivations of Saccharomyces cerevisiae. Biotechnol. Bioeng. 2003, 87:766.
    • (2003) Biotechnol. Bioeng. , vol.87 , pp. 766
    • Lei, F.1    Olsson, L.2    Jorgensen, S.B.3
  • 5
    • 0033929520 scopus 로고    scopus 로고
    • Optimization of ethanol production in Saccharomyces cerevisiae by metabolic engineering of the ammonium assimilation
    • Nissen T.L., Kielland-Brandt M.C., Nielsen J., Villadsen J. Optimization of ethanol production in Saccharomyces cerevisiae by metabolic engineering of the ammonium assimilation. Metab. Eng. 2000, 2:69.
    • (2000) Metab. Eng. , vol.2 , pp. 69
    • Nissen, T.L.1    Kielland-Brandt, M.C.2    Nielsen, J.3    Villadsen, J.4
  • 6
    • 0023385129 scopus 로고
    • Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes
    • Westerhoff H.V., Kell D.B. Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes. Biotechnol. Bioeng. 1987, 30:101.
    • (1987) Biotechnol. Bioeng. , vol.30 , pp. 101
    • Westerhoff, H.V.1    Kell, D.B.2
  • 7
    • 0029823882 scopus 로고    scopus 로고
    • Effect of product inhibition on lactic acid fermentation: simulation and modelling
    • Dutta S.K., Mukherjee A., Chakraborty P. Effect of product inhibition on lactic acid fermentation: simulation and modelling. Appl. Microbiol. Biotechnol. 1996, 46:410.
    • (1996) Appl. Microbiol. Biotechnol. , vol.46 , pp. 410
    • Dutta, S.K.1    Mukherjee, A.2    Chakraborty, P.3
  • 8
    • 0023746858 scopus 로고
    • Intracellular accumulation of AMP as a cause for the decline in rate of ethanol production by Saccharomyces cerevisiae during batch fermentation
    • Dombek K.M., Ingram L.O. Intracellular accumulation of AMP as a cause for the decline in rate of ethanol production by Saccharomyces cerevisiae during batch fermentation. Appl. Environ. Microbiol. 1988, 54:98.
    • (1988) Appl. Environ. Microbiol. , vol.54 , pp. 98
    • Dombek, K.M.1    Ingram, L.O.2
  • 9
    • 0023250471 scopus 로고
    • Ethanol production during batch fermentation with Saccharomyces cerevisiae: changes in glycolytic enzymes and internal pH
    • Dombek K.M., Ingram L.O. Ethanol production during batch fermentation with Saccharomyces cerevisiae: changes in glycolytic enzymes and internal pH. Appl. Environ. Microbiol. 1987, 53:1286.
    • (1987) Appl. Environ. Microbiol. , vol.53 , pp. 1286
    • Dombek, K.M.1    Ingram, L.O.2
  • 10
    • 0031957626 scopus 로고    scopus 로고
    • Ethanol-induced water stress in yeast
    • Hallsworth J.E. Ethanol-induced water stress in yeast. J. Ferment. Bioeng. 1998, 85:125.
    • (1998) J. Ferment. Bioeng. , vol.85 , pp. 125
    • Hallsworth, J.E.1
  • 11
    • 34250198994 scopus 로고    scopus 로고
    • Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway
    • Kitagaki H., Araki Y., Funato K., Shimoi H. Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway. FEBS Lett. 2007, 581:2935.
    • (2007) FEBS Lett. , vol.581 , pp. 2935
    • Kitagaki, H.1    Araki, Y.2    Funato, K.3    Shimoi, H.4
  • 12
    • 0021957625 scopus 로고
    • Regulation and butanol inhibition of d-xylose and d-glucose uptake in Clostridium acetobutylicum
    • Ounine K., Petitdemange H., Raval G., Gay R. Regulation and butanol inhibition of d-xylose and d-glucose uptake in Clostridium acetobutylicum. Appl. Environ. Microbiol. 1985, 49:874.
    • (1985) Appl. Environ. Microbiol. , vol.49 , pp. 874
    • Ounine, K.1    Petitdemange, H.2    Raval, G.3    Gay, R.4
  • 13
    • 0028501233 scopus 로고
    • Mathematical modeling of in hibitio kinetics in acetone-butanol fermentation by Clostriidium acetobutylicum
    • Yang X., Tsao G.T. Mathematical modeling of in hibitio kinetics in acetone-butanol fermentation by Clostriidium acetobutylicum. Biotechnol. Prog. 1994, 10:532.
    • (1994) Biotechnol. Prog. , vol.10 , pp. 532
    • Yang, X.1    Tsao, G.T.2
  • 14
    • 0014658880 scopus 로고
    • Biochemical systems analysis. II: The steady-state solutions for an n-pool systems using a power-law approximation
    • Savageau M.A. Biochemical systems analysis. II: The steady-state solutions for an n-pool systems using a power-law approximation. J. Theor. Biol. 1969, 25:370.
    • (1969) J. Theor. Biol. , vol.25 , pp. 370
    • Savageau, M.A.1
  • 16
    • 0026495410 scopus 로고
    • The tricarboxylic acid cycle in Dictyostelium discoideum. I: Formulation of alternative kinetic representations
    • Shiraishi F., Savageau M.A. The tricarboxylic acid cycle in Dictyostelium discoideum. I: Formulation of alternative kinetic representations. J. Biol. Chem. 1992, 267:22912.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22912
    • Shiraishi, F.1    Savageau, M.A.2
  • 17
    • 20444478968 scopus 로고    scopus 로고
    • Computation and analysis of time-dependent sensitivities in generalized mass action systems
    • Schwachke J.H., Voit E.O. Computation and analysis of time-dependent sensitivities in generalized mass action systems. J. Theor. Biol. 2005, 236:21.
    • (2005) J. Theor. Biol. , vol.236 , pp. 21
    • Schwachke, J.H.1    Voit, E.O.2
  • 18
    • 33947696246 scopus 로고    scopus 로고
    • Dynamic sensitivities in chaotic dynamical systems
    • Shiraishi F., Hatoh Y. Dynamic sensitivities in chaotic dynamical systems. Appl. Math. Comput. 2007, 186:1347.
    • (2007) Appl. Math. Comput. , vol.186 , pp. 1347
    • Shiraishi, F.1    Hatoh, Y.2
  • 19
    • 0032464348 scopus 로고    scopus 로고
    • Analysis and optimization of biochemical process reaction pathways. 1: Pathway sensitivities and identification of limiting steps
    • Conejeros R., Vassiliadis V.S. Analysis and optimization of biochemical process reaction pathways. 1: Pathway sensitivities and identification of limiting steps. Ind. Eng. Chem. Res. 1998, 37:4699.
    • (1998) Ind. Eng. Chem. Res. , vol.37 , pp. 4699
    • Conejeros, R.1    Vassiliadis, V.S.2
  • 20
    • 61649101765 scopus 로고    scopus 로고
    • A method for determination of the main bottleneck enzyme in a metabolic reaction
    • Shiraishi F., Suzuki Y. A method for determination of the main bottleneck enzyme in a metabolic reaction. Ind. Eng. Chem. Res. 2009, 48:415.
    • (2009) Ind. Eng. Chem. Res. , vol.48 , pp. 415
    • Shiraishi, F.1    Suzuki, Y.2
  • 21
    • 13844253731 scopus 로고    scopus 로고
    • An efficient method for calculation of dynamic logarithmic gains in biochemical systems theory
    • Shiraishi F., Hatoh Y., Irie T. An efficient method for calculation of dynamic logarithmic gains in biochemical systems theory. J. Theor. Biol. 2005, 234:79.
    • (2005) J. Theor. Biol. , vol.234 , pp. 79
    • Shiraishi, F.1    Hatoh, Y.2    Irie, T.3
  • 22
    • 0029902666 scopus 로고    scopus 로고
    • Model assessment and refinement using strategies from biochemical systems theory: application to metabolism in human red blood cells
    • Ni T.C., Savageau M.A. Model assessment and refinement using strategies from biochemical systems theory: application to metabolism in human red blood cells. J. Theor. Biol. 1996, 179:329.
    • (1996) J. Theor. Biol. , vol.179 , pp. 329
    • Ni, T.C.1    Savageau, M.A.2
  • 23
    • 77957662796 scopus 로고    scopus 로고
    • Identification of bottleneck enzymes with negative dynamic sensitivities: ethanol fermentation systems as case studies, J. Biotechnol., in press.
    • K. Sriyudthsak, F. Shiraishi, Identification of bottleneck enzymes with negative dynamic sensitivities: ethanol fermentation systems as case studies, J. Biotechnol., in press.
    • Sriyudthsak, K.1    Shiraishi, F.2
  • 24
    • 77749337515 scopus 로고    scopus 로고
    • Instantaneous and overall indicators for determination of bottleneck ranking in metabolic reaction networks
    • Sriyudthsak K., Shiraishi F. Instantaneous and overall indicators for determination of bottleneck ranking in metabolic reaction networks. Ind. Eng. Chem. Res. 2010, 49:2122.
    • (2010) Ind. Eng. Chem. Res. , vol.49 , pp. 2122
    • Sriyudthsak, K.1    Shiraishi, F.2
  • 25
    • 0029118323 scopus 로고
    • Comparative characterization of the fermentation pathway of Saccharomyces cerevisiae using biochemical systems theory and metabolic control analysis: model definition and nomenclature
    • Curto R., Sorribas A., Cascante M. Comparative characterization of the fermentation pathway of Saccharomyces cerevisiae using biochemical systems theory and metabolic control analysis: model definition and nomenclature. Math. Biosci. 1995, 130:25.
    • (1995) Math. Biosci. , vol.130 , pp. 25
    • Curto, R.1    Sorribas, A.2    Cascante, M.3
  • 26
    • 0023274983 scopus 로고
    • Adaptation of yeast cell membranes to ethanol
    • Jimenez J., Benitez T. Adaptation of yeast cell membranes to ethanol. Appl. Environ. Microbiol. 1987, 53:1196.
    • (1987) Appl. Environ. Microbiol. , vol.53 , pp. 1196
    • Jimenez, J.1    Benitez, T.2
  • 27
    • 0022387355 scopus 로고
    • Role of mitochondria in ethanol tolerance of Saccharomyces cerevisiae
    • Aguilera A., Benitez T. Role of mitochondria in ethanol tolerance of Saccharomyces cerevisiae. Arch. Microbiol. 1985, 142:389.
    • (1985) Arch. Microbiol. , vol.142 , pp. 389
    • Aguilera, A.1    Benitez, T.2
  • 28
    • 0025400371 scopus 로고
    • Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae
    • Galazzo J.L., Bailey J.E. Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae. Enzyme Microb. Technol. 1990, 12:162.
    • (1990) Enzyme Microb. Technol. , vol.12 , pp. 162
    • Galazzo, J.L.1    Bailey, J.E.2
  • 29
    • 85045824089 scopus 로고
    • Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae
    • Galazzo J.L., Bailey J.E. Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae. Errata. Enzyme Microb. Technol. 1991, 13:363.
    • (1991) Errata. Enzyme Microb. Technol. , vol.13 , pp. 363
    • Galazzo, J.L.1    Bailey, J.E.2
  • 30
    • 0022038567 scopus 로고
    • Kinetics of ethanol inhibition in alcohol fermentation
    • Luong J.H.T. Kinetics of ethanol inhibition in alcohol fermentation. Biotechnol. Bioeng. 1985, 27:280.
    • (1985) Biotechnol. Bioeng. , vol.27 , pp. 280
    • Luong, J.H.T.1
  • 31
    • 0002148613 scopus 로고
    • Kinetic analysis for batch ethanol fermentation of Saccharomyces cerevisiae
    • Nanba A., Nishizawa Y., Tsuchiya Y., Nagai S. Kinetic analysis for batch ethanol fermentation of Saccharomyces cerevisiae. J. Ferment. Technol. 1987, 65:277.
    • (1987) J. Ferment. Technol. , vol.65 , pp. 277
    • Nanba, A.1    Nishizawa, Y.2    Tsuchiya, Y.3    Nagai, S.4
  • 32
    • 77957671922 scopus 로고    scopus 로고
    • A rapid and highly-reliable method for calculation of dynamic sensitivities in a large-scale metabolic reaction system, in: ICMSB2006, Munchen,
    • F. Shiraishi, T. Tomita, H. Hirayama, A rapid and highly-reliable method for calculation of dynamic sensitivities in a large-scale metabolic reaction system, in: ICMSB2006, Munchen, 2006.
    • (2006)
    • Shiraishi, F.1    Tomita, T.2    Hirayama, H.3
  • 33
    • 70450223697 scopus 로고    scopus 로고
    • A reliable Taylor series-based computational method for the calculation of dynamic sensitivities in large-scale metabolic reaction systems: algorithmic and software evaluation
    • Shiraishi F., Tomita T., Iwata M., Berrada A.A. A reliable Taylor series-based computational method for the calculation of dynamic sensitivities in large-scale metabolic reaction systems: algorithmic and software evaluation. Math. Biosci. 2009, 222:73.
    • (2009) Math. Biosci. , vol.222 , pp. 73
    • Shiraishi, F.1    Tomita, T.2    Iwata, M.3    Berrada, A.A.4
  • 34
    • 0023324424 scopus 로고
    • A simple device for fed-batch control in alcohol fermentation
    • Mota M., Besle J.M., Strehaiano P., Goma G. A simple device for fed-batch control in alcohol fermentation. Biotechnol. Bioeng. 1987, 29:775.
    • (1987) Biotechnol. Bioeng. , vol.29 , pp. 775
    • Mota, M.1    Besle, J.M.2    Strehaiano, P.3    Goma, G.4
  • 35
    • 0024016073 scopus 로고
    • Application of characteristic reaction paths: rate-limiting capability of phosphofructokinase in yeast fermentation
    • Liao J.C., Lightfoot E.N.J., Jolly S.O., Jacobson G.K. Application of characteristic reaction paths: rate-limiting capability of phosphofructokinase in yeast fermentation. Biotechnol. Bioeng. 1988, 31:855.
    • (1988) Biotechnol. Bioeng. , vol.31 , pp. 855
    • Liao, J.C.1    Lightfoot, E.N.J.2    Jolly, S.O.3    Jacobson, G.K.4
  • 36
    • 0032485838 scopus 로고    scopus 로고
    • Application of mathematical tools for metabolic design of microbial ethanol production
    • Hatzimanikatis V., Emmerling M., Sauer U., Bailey J.E. Application of mathematical tools for metabolic design of microbial ethanol production. Biotechnol. Bioeng. 1997, 58:154.
    • (1997) Biotechnol. Bioeng. , vol.58 , pp. 154
    • Hatzimanikatis, V.1    Emmerling, M.2    Sauer, U.3    Bailey, J.E.4
  • 37
    • 0020665080 scopus 로고
    • By-product inhibition effects on ethanolic fermentation by Saccharomyces cerevisiae
    • Maiorella B., Blanch H.W., Charles R. By-product inhibition effects on ethanolic fermentation by Saccharomyces cerevisiae. Biotechnol. Bioeng. 1983, 25:103.
    • (1983) Biotechnol. Bioeng. , vol.25 , pp. 103
    • Maiorella, B.1    Blanch, H.W.2    Charles, R.3
  • 38
    • 0023385299 scopus 로고
    • A new immobilized cell system with protection against toxic solvents
    • Tanaka H., Harada S., Kurosawa H., Yajima M. A new immobilized cell system with protection against toxic solvents. Biotechnol. Bioeng. 1987, 30:22.
    • (1987) Biotechnol. Bioeng. , vol.30 , pp. 22
    • Tanaka, H.1    Harada, S.2    Kurosawa, H.3    Yajima, M.4
  • 39
    • 0017857332 scopus 로고
    • Plasma-membrane lipid composition and ethanol tolerance in Saccharomyces cerevisiae
    • Thomas D.S., Hossack J.A., Rose A.H. Plasma-membrane lipid composition and ethanol tolerance in Saccharomyces cerevisiae. Arch. Microbiol. 1978, 117:239.
    • (1978) Arch. Microbiol. , vol.117 , pp. 239
    • Thomas, D.S.1    Hossack, J.A.2    Rose, A.H.3
  • 40
    • 0030169395 scopus 로고    scopus 로고
    • A kinetic model for the penicillin biosynthetic pathway in Penicillium chrysogenum
    • Nielsen J., Jorgensen H.S. A kinetic model for the penicillin biosynthetic pathway in Penicillium chrysogenum. Control Eng. Practice 1996, 4:765.
    • (1996) Control Eng. Practice , vol.4 , pp. 765
    • Nielsen, J.1    Jorgensen, H.S.2
  • 41
    • 0029294006 scopus 로고
    • Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Penicillium chrysogenum
    • Nielsen J., Jorgensen H.S. Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Penicillium chrysogenum. Biotechnol. Prog. 1995, 11:299.
    • (1995) Biotechnol. Prog. , vol.11 , pp. 299
    • Nielsen, J.1    Jorgensen, H.S.2


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