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Volumn 48, Issue 1, 2009, Pages 415-423

Method for determination of the main bottleneck enzyme in a metabolic reaction network by dynamic sensitivity analysis

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOMOLECULES; DYNAMIC ANALYSIS; DYNAMIC RESPONSE; ENZYMES; FERMENTATION; METABOLISM; METABOLITES; PROCESS CONTROL; SENSITIVITY ANALYSIS;

EID: 61649101765     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie8005963     Document Type: Article
Times cited : (8)

References (23)
  • 1
    • 0032464348 scopus 로고    scopus 로고
    • Analysis and optimization of biochemical process reaction pathways. 1. Pathway sensitivities and identification of limiting steps
    • Conejeros, R.; Vassiliadis, V. S. Analysis and optimization of biochemical process reaction pathways. 1. Pathway sensitivities and identification of limiting steps. Ind. Eng. Chem. Res. 1998, 37, 4699-4708.
    • (1998) Ind. Eng. Chem. Res , vol.37 , pp. 4699-4708
    • Conejeros, R.1    Vassiliadis, V.S.2
  • 2
    • 0032455049 scopus 로고    scopus 로고
    • Analysis and optimization of biochemical process reaction pathways. 2. Optimal selection of reaction steps for modification
    • Conejeros, R.; Vassiliadis, V. S. Analysis and optimization of biochemical process reaction pathways. 2. Optimal selection of reaction steps for modification. Ind. Eng. Chem. Res. 1998, 37, 4709-4714.
    • (1998) Ind. Eng. Chem. Res , vol.37 , pp. 4709-4714
    • Conejeros, R.1    Vassiliadis, V.S.2
  • 3
    • 0034607679 scopus 로고    scopus 로고
    • Dynamic biochemical reaction process analysis and pathway modification predictions
    • Conejeros, R.; Vassiliadis, V. S. Dynamic biochemical reaction process analysis and pathway modification predictions. Biotechnol. Bioeng. 2000, 68, 285-297.
    • (2000) Biotechnol. Bioeng , vol.68 , pp. 285-297
    • Conejeros, R.1    Vassiliadis, V.S.2
  • 4
    • 0037466509 scopus 로고    scopus 로고
    • Sensitivity analysis of stoichiometric networks: An extension of metabolic control analysis to non-steady state trajectories
    • Ingalls, B. P.; Sauro, H. M. Sensitivity analysis of stoichiometric networks: An extension of metabolic control analysis to non-steady state trajectories. J. Theor. Biol. 2003, 222, 23-36.
    • (2003) J. Theor. Biol , vol.222 , pp. 23-36
    • Ingalls, B.P.1    Sauro, H.M.2
  • 5
    • 13844253731 scopus 로고    scopus 로고
    • An efficient method for calculation of dynamic logarithmic gains in biochemical systems theory
    • Shiraishi, F.; Hatoh, Y.; Irie, T. An efficient method for calculation of dynamic logarithmic gains in biochemical systems theory. J. Theor. Biol. 2005, 234, 79-85.
    • (2005) J. Theor. Biol , vol.234 , pp. 79-85
    • Shiraishi, F.1    Hatoh, Y.2    Irie, T.3
  • 6
    • 20444478968 scopus 로고    scopus 로고
    • Computation and analysis of time-dependent sensitivities in generalized mass action systems
    • Schwacke, J. H.; Voit, E. O. Computation and analysis of time-dependent sensitivities in generalized mass action systems. J. Theor. Biol. 2005, 236, 21-38.
    • (2005) J. Theor. Biol , vol.236 , pp. 21-38
    • Schwacke, J.H.1    Voit, E.O.2
  • 7
    • 0026495410 scopus 로고
    • The tricarboxylic acid cycle in Dictyostelium discoideum: I. Formulation of alternative kinetic representations
    • Shiraishi, F.; Savageau, M. A. The tricarboxylic acid cycle in Dictyostelium discoideum: I. Formulation of alternative kinetic representations. J. Biol. Chem. 1992, 267 (32), 22912-22918.
    • (1992) J. Biol. Chem , vol.267 , Issue.32 , pp. 22912-22918
    • Shiraishi, F.1    Savageau, M.A.2
  • 8
    • 0026470975 scopus 로고
    • The tricarboxylic acid cycle in Dictyostelium discoideum: II. Evaluation of model consistency and robustness
    • Shiraishi, F.; Savageau, M. A. The tricarboxylic acid cycle in Dictyostelium discoideum: II. Evaluation of model consistency and robustness. J. Biol. Chem. 1992b, 267 (32), 22919-22925.
    • (1992) J. Biol. Chem , vol.267 , Issue.32 , pp. 22919-22925
    • Shiraishi, F.1    Savageau, M.A.2
  • 9
    • 0026470976 scopus 로고
    • The tricarboxylic acid cycle in Dictyostelium discoideum: III. Analysis of steady-state and dynamic behavior
    • Shiraishi, F.; Savageau, M. A. The tricarboxylic acid cycle in Dictyostelium discoideum: III. Analysis of steady-state and dynamic behavior. J. Biol. Chem. 1992c, 267 (32), 22926-22933.
    • (1992) J. Biol. Chem , vol.267 , Issue.32 , pp. 22926-22933
    • Shiraishi, F.1    Savageau, M.A.2
  • 10
    • 0026463865 scopus 로고
    • The tricarboxylic acid cycle in Dictyostelium discoideum: IV. Resolution of discrepancies between alternative methods of analysis
    • Shiraishi, F.; Savageau, M. A. The tricarboxylic acid cycle in Dictyostelium discoideum: IV. Resolution of discrepancies between alternative methods of analysis. J. Biol. Chem. 1992d, 267 (32), 22934-22943.
    • (1992) J. Biol. Chem , vol.267 , Issue.32 , pp. 22934-22943
    • Shiraishi, F.1    Savageau, M.A.2
  • 11
    • 0027321318 scopus 로고
    • The tricarboxylic acid cycle in Dictyostelium discoideum: Systemic effects of including protein turnover in the current model
    • Shiraishi, F.; Savageau, M. A. The tricarboxylic acid cycle in Dictyostelium discoideum: Systemic effects of including protein turnover in the current model. J. Biol. Chem. 1993, 268 (23), 16917-16928.
    • (1993) J. Biol. Chem , vol.268 , Issue.23 , pp. 16917-16928
    • Shiraishi, F.1    Savageau, M.A.2
  • 13
    • 0014649230 scopus 로고
    • Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions
    • Savageau, M. A. Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions. J. Theor. Biol. 1969, 25, 365-369.
    • (1969) J. Theor. Biol , vol.25 , pp. 365-369
    • Savageau, M.A.1
  • 15
    • 34547122015 scopus 로고    scopus 로고
    • A simple and highly accurate numerical differentiation method for sensitivity analysis of large-scale metabolic reaction systems
    • Shiraishi, F.; Furuta, S.; Ishimatsu, T.; Akhter, J. A simple and highly accurate numerical differentiation method for sensitivity analysis of large-scale metabolic reaction systems. Math. Biosci. 2007, 208, 590-606.
    • (2007) Math. Biosci , vol.208 , pp. 590-606
    • Shiraishi, F.1    Furuta, S.2    Ishimatsu, T.3    Akhter, J.4
  • 16
    • 0037170719 scopus 로고    scopus 로고
    • A Taylor-series solution in Cartesian space to GMA-system equations and its application to initial-value problems
    • Shiraishi, F.; Takeuchi, H.; Hasegawa, T.; Nagasue, H. A Taylor-series solution in Cartesian space to GMA-system equations and its application to initial-value problems. Appl. Math. Comput. 2002, 127, 103-123.
    • (2002) Appl. Math. Comput , vol.127 , pp. 103-123
    • Shiraishi, F.1    Takeuchi, H.2    Hasegawa, T.3    Nagasue, H.4
  • 17
    • 61649128378 scopus 로고    scopus 로고
    • Solution of ordinary differential equations by Taylor series method
    • Hirayama, H.; Komiya, S.; Sato, S. Solution of ordinary differential equations by Taylor series method. SIAM J. Appl. Math. 2002, 12, 1-8.
    • (2002) SIAM J. Appl. Math , vol.12 , pp. 1-8
    • Hirayama, H.1    Komiya, S.2    Sato, S.3
  • 18
    • 15844370671 scopus 로고    scopus 로고
    • Pathway kinetics and metabolic control analysis of a high-yielding strain of Penicillium chrysogenum during fed batch cultivations
    • Pissara, P. N.; Nielsen, J.; Bazin, M. J. Pathway kinetics and metabolic control analysis of a high-yielding strain of Penicillium chrysogenum during fed batch cultivations. Biotechnol. Bioeng. 1996, 51, 168-176.
    • (1996) Biotechnol. Bioeng , vol.51 , pp. 168-176
    • Pissara, P.N.1    Nielsen, J.2    Bazin, M.J.3
  • 19
    • 0030169395 scopus 로고    scopus 로고
    • A kinetic model for the penicillin biosynthetic pathway in Pénicillium chrysogenum
    • Nielsen, J.; Jorgensen, H. S. A kinetic model for the penicillin biosynthetic pathway in Pénicillium chrysogenum. Control Eng. Practice 1996, 4, 765-771.
    • (1996) Control Eng. Practice , vol.4 , pp. 765-771
    • Nielsen, J.1    Jorgensen, H.S.2
  • 20
    • 0029294006 scopus 로고
    • Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Penicillim chrysogenum
    • Nielsen, J.; Jorgensen, H. S. Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Penicillim chrysogenum. Biotechnol. Prog. 1995, 11, 299-305.
    • (1995) Biotechnol. Prog , vol.11 , pp. 299-305
    • Nielsen, J.1    Jorgensen, H.S.2
  • 21
    • 0015989446 scopus 로고
    • A linear steady-state treatment of enzymatic chains
    • Heinrich, R.; Rapoport, T. A linear steady-state treatment of enzymatic chains. Eur. J. Biochem. 1974, 42, 89-95.
    • (1974) Eur. J. Biochem , vol.42 , pp. 89-95
    • Heinrich, R.1    Rapoport, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.