Crosstalk between insulin receptor and G protein-coupled receptor signaling systems leads to Ca2+ oscillations in pancreatic cancer PANC-1 cells

Biochemical and Biophysical Research Communications

Volumn 401, Issue 1, 2010, Pages 154-158

  Young, Steven H ^a   Rozengurt, Enrique ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ca2+ oscillations; Pancreatic cancer; Rapamycin; Signaling crosstalk

Indexed keywords

CALCIUM ION; G PROTEIN COUPLED RECEPTOR; INSULIN RECEPTOR; NEUROTENSIN; RAPAMYCIN;

ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CELL CULTURE; CELL SUBPOPULATION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; OSCILLATION; PANCREAS CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CALCIUM; CALCIUM SIGNALING; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; HUMANS; INSULIN; NEUROTENSIN; PANCREATIC NEOPLASMS; RECEPTOR, INSULIN; RECEPTORS, G-PROTEIN-COUPLED; TRANSCRIPTION FACTORS;

EID: 77957660483     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.09.036     Document Type: Article

References (33)

1. Brand R.E., Tempero M.A. Pancreatic cancer. Curr. Opin. Oncol. 1998, 10:362-366.
2. Woll P.J., Rozengurt E. Multiple neuropeptides mobilise calcium in small cell lung cancer: effects of vasopressin, bradykinin, cholecystokinin, galanin and neurotensin. Biochem. Biophys. Res. Commun. 1989, 164:66-73.
3. Langdon S., Sethi T., Ritchie A., Muir M., Smyth J., Rozengurt E. Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer Res. 1992, 52:4554-4557.
4. Rozengurt E., Walsh J.H. Gastrin, CCK, signaling, and cancer. Annu. Rev. Physiol. 2001, 63:49-76.
5. Rozengurt E. Neuropeptides as growth factors for normal and cancer cells. Trends Endocrinol. Metab. 2002, 13:128-134.
6. Rozengurt E. Mitogenic signaling pathways induced by G protein-coupled receptors. J. Cell. Physiol. 2007, 213:589-602.
7. Heasley L.E. Autocrine and paracrine signaling through neuropeptide receptors in human cancer. Oncogene 2001, 20:1563-1569.
8. Dorsam R.T., Gutkind J.S. G-protein-coupled receptors and cancer. Nat. Rev. Cancer 2007, 7:79-94.
9. Z. Kan, B.S. Jaiswal, J. Stinson, V. Janakiraman, D. Bhatt, H.M. Stern, P. Yue, P.M. Haverty, R. Bourgon, J. Zheng, M. Moorhead, S. Chaudhuri, L.P. Tomsho, B.A. Peters, K. Pujara, S. Cordes, D.P. Davis, V.E.H. Carlton, W. Yuan, L. Li, W. Wang, C. Eigenbrot, J.S. Kaminker, D.A. Eberhard, P. Waring, S.C. Schuster, Z. Modrusan, Z. Zhang, D. Stokoe, F.J. de Sauvage, M. Faham, S. Seshagiri, Diverse somatic mutation patterns and pathway alterations in human cancers, Nature advance online publication, 2010.
10. Ryder N.M., Guha S., Hines O.J., Reber H.A., Rozengurt E. G protein-coupled receptor signaling in human ductal pancreatic cancer cells: Neurotensin responsiveness and mitogenic stimulation. J. Cell. Physiol. 2001, 186:53-64.
11. Guha S., Rey O., Rozengurt E. Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1. Cancer Res. 2002, 62:1632-1640.
12. Guha S., Lunn J.A., Santiskulvong C., Rozengurt E. Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1. Cancer Res. 2003, 63:2379-2387.
13. Kisfalvi K., Guha S., Rozengurt E. Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells. J. Cell. Physiol. 2005, 202:880-890.
14. Kisfalvi K., Eibl G., Sinnett-Smith J., Rozengurt E. Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth. Cancer Res. 2009, 69:6539-6545.
15. Seckl M.J., Higgins T., Widmer F., Rozengurt E. [d-Arg1, d-Trp5, 7, 9, Leu11]substance P: a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells. Cancer Res. 1997, 57:51-54.
16. Sinnett-Smith J., Santiskulvong C., Duque J., Rozengurt E. d-Arg(1), d-Trp(5, 7, 9), Leu(11)]substance P inhibits bombesin-induced mitogenic signal transduction mediated by both G(q) and G(12) in Swiss 3T3 cells. J. Biol. Chem. 2000, 275:30644-30652.
17. Guha S., Eibl G., Kisfalvi K., Fan R.S., Burdick M., Reber H., Hines O.J., Strieter R., Rozengurt E. Broad-spectrum G protein-coupled receptor antagonist, [d-Arg1, d-Trp5, 7, 9, Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res. 2005, 65:2738-2745.
18. Elek J., Pinzon W., Park K.H., Narayanan R. Relevant genomics of neurotensin receptor in cancer. Anticancer Res. 2000, 20:53-58.
19. Wang L., Friess H., Zhu Z., Graber H., Zimmermann A., Korc M., Reubi J.C., Bèuchler M.W. Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease. Clin. Cancer Res. 2000, 6:566-571.
20. Reubi J.C., Waser B., Friess H., Bèuchler M., Laissue J. Neurotensin receptors: a new marker for human ductal pancreatic adenocarcinoma. Gut 1998, 42:546-550.
21. Arafat H.A., Gong Q., Chipitsyna G., Rizvi A., Saa C.T., Yeo C.J. Antihypertensives as novel antineoplastics: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma. J. Am. Coll. Surg. 2007, 204:996-1005.
22. 2+ signaling and phosphatidylinositol 4, 5-bisphosphate hydrolysis induced by Gq protein-coupled receptor agonists through an mTOR-dependent pathway. Endocrinology 2007, 148:3246-3257.
23. Rozengurt E., Sinnett-Smith J., Kisfalvi K. Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer. Clin. Cancer Res. 2010, 16:2505-2511.
24. Taniguchi C.M., Emanuelli B., Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nat. Rev. Mol. Cell. Biol. 2006, 7:85-96.
25. Giovannucci E., Michaud D. The role of obesity and related metabolic disturbances in cancers of the colon. Prostate Pancreas Gastroenterol. 2007, 132:2208-2225.
26. Ballian N., Brunicardi F.C. Islet vasculature as a regulator of endocrine pancreas function. World J. Surg. 2007, 31:705-714.
27. Bertelli E., Regoli M., Orazioli D., Bendayan M. Association between islets of Langerhans and pancreatic ductal system in adult rat. Where endocrine and exocrine meet together?. Diabetologia 2001, 44:575-584.
28. Yuan J., Rozengurt E. PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells. J. Cell. Biochem. 2008, 103:648-662.
29. Kisfalvi K., Hurd C., Guha S., Rozengurt E. Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells. J. Cell. Physiol. 2010, 223:309-316.
30. 2+-sensing receptor. Am. J. Physiol. Cell Physiol. 2002, 282:C1414-C1422.
31. Berridge M.J., Lipp P., Bootman M.D. The versatility and universality of calcium signalling. Nat. Rev. Mol. Cell. Biol. 2000, 1:11-21.
32. Clapham D.E. Calcium Signal. Cell 2007, 131:1047.
33. Brandman O., Meyer T. Feedback loops shape cellular signals in space and time. Science 2008, 322:390-395.