Peanut allergy

Current Opinion in Pediatrics

Volumn 22, Issue 5, 2010, Pages 642-646

  Pansare, Milind ^a   Kamat, Deepak ^b  

^a WAYNE STATE UNIVERSITY   (United States)

^b CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

desensitization; novel diagnostics; peanut allergy prevalence

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; PEANUT PROTEIN; UNCLASSIFIED DRUG;

BLOOD LEVEL; DESENSITIZATION; HELPER CELL; HIGH RISK INFANT; HUMAN; IMMUNOTHERAPY; PEANUT ALLERGY; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SKIN PRICK TEST;

ALLERGENS; ARACHIS HYPOGAEA; DESENSITIZATION, IMMUNOLOGIC; HUMANS; IMMUNE TOLERANCE; IMMUNOTHERAPY; PEANUT HYPERSENSITIVITY;

EID: 77957603763     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e32833d95cb     Document Type: Review

References (33)

1. Sicherer SH, Munoz-Furlong A, Burks AW, Sampson HA. Prevalence of peanut and tree nut allergy in US determined by a random digit dial telephone survey. J Allergy Clin Immunol 1999;103:559-562.
2. Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to food. J Allergy Clin Immunol 2001;107:191-193.
3. Primeasu MN, Kagan R, Joseph L, et al. The psychological burden of peanut allergy as perceived by adults with peanut allergy and the parents of peanut allergic children. Clin Exp Allergy 2000;30:1135-1143.
4. Grundy J, Matthews S, Bateman B, Arshad SH. Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. J Allergy Clin Immunol 2002;110:784-789.
5. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of random digit dial telephone survey: a 5 year follow-up study. J Allergy Clin Immunol 2003;112:1203-1207.
6. Venter C, Arshad SH, Grundy J, et al. Time trends in the prevalence of peanut allergy: three cohorts of children from the same geographical location in the UK. Allergy 2010;65:103-108. Interesting observation of peanut prevalence in cohorts of preschoolers in the same geographic area. The reasons for the stable trend are not clear.
7. Mullins RJ, Dear KB, Tang ML. Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007. J Allergy Clin Immunol 2009;123:689-693. This study also documents an increasing trend of peanut allergy without explainable reasons. Importantly, the study indicated severe reactions with later age onset of peanut allergy, contrary to previous belief. Milder symptoms at later age are believed to be due to class 2 allergen (inhalant) crossreactivity.
8. Du Toit G, Katz Y, Sassieni P, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol 2008;122:984-991.
9. Fox AT, Sasieni P, Du Toit G, et al. Household peanut consumption as a risk factor for the development of peanut allergy. J Allergy Clin Immunol 2009;123:417-423. Another study suggesting nonoral peanut exposure is a likely cause of sensitization, whereas early oral peanut exposure will facilitate tolerance.
10. Immune Tolerance Network. About the LEAP study; 2006. http://www.leap study.com/study-about.html. [accessed February 2010]
11. Boulay A, Houghton J, Gancheva V, et al. A Euro Prevall review of factors affecting incidence of peanut allergy: priorities for research and policy. Allergy 2008;63:797-809.
12. Sicherer SH, Sampson HA. Peanut allergy: emerging concepts and approaches for an apparent epidemic. J Allergy Clin Immunol 2007;120:491-503.
13. Chung SY, Butts CL, Maleki SJ, Champagne E. Linking peanut allergenicity to the process of maturation, curing, and roasting. J Agric Food Chem 2003;51:4273-4277.
14. Chung SY, Champagne ET. Allergenicity of Maillard reaction products from peanut proteins. J Agric Food Chem 1999;47:5227-5231.
15. Nowak-Wegryzyn A, Fiocchi A. Rare, medium or well done? The effect of heating and food matrix on food protein allergenicity. Curr Opin Allergy Clin Immunol 2009;9:234-237. The authors discuss the complexity of food processing and food matrix and expression of food allergenicity.
16. Roberts G, Lack G. Diagnosing peanut allergy with skin prick and specific IgE testing. J Allergy Clin Immunol 2005;115:1291-1296.
17. Asero R, Ballmer-Weber BK, Beyer K, et al. IgE mediated food allergy diagnosis: current status and new perspectives. Mol Nutr Food Res 2007;51:135-147.
18. Sampson HA. Clinical practice: peanut allergy. N Engl J Med 2002;346:1294-1299.
19. Niggermann B, Rolinck-Werninhaus C, Mehl A, et al. Controlled oral food challenges in children: when indicated, when superfluous? Allergy 2005;60:865-870.
20. Sampson HA. Utility of food specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001;107:891-896.
21. Rance F, Abbai M, Lauwers-Cances V. Improved screening for peanut allergy by the combined use of skin prick tests and specific IgE assays. J Allergy Clin Immunol 2002;109:1027-1033.
22. Beyer K, Ellmann-Grunther L, Jarvinen KM, et al. Measurement of peptide specific IgE as an additional tool in identifying patients with clinical reactivity to peanuts. J Allergy Clin Immunol 2003;112:202-207.
23. Cercedo I, Zamora J, Shreffler WG, et al. Mapping of IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay. J Allergy Clin Immunol 2008;122:589-594.
24. Nicolaou N, Poorafashar M, Murray C, et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using componentresolved diagnostics. J Allergy Clin Immunol 2010;125:191-197. There is no test apart from DBPCFC available to distinguish peanut sensitization and clinical sensitivity. An accurate test to differentiate this is required. The component-resolved diagnostic (CRD) test is proposed by the authors, but requires validation in large trials and varied population.
25. Albrecht M, Kuhne Y, Ballmer-Weber BK, et al. Relevance of IgE binding to short peptides for the allergenic activity of food allergen. J Allergy Clin Immunol 2009;124:1267-1272.
26. Ko J, Mayer L Oral tolerance: lessons on food allergy. Eur J Gastroenterol Hepatol 2005;17:1299-1303.
27. Patricia G, Nucera E, Roncallo C, et al. Oral desensitizing treatment in food allergy: clinical and immunological results. Aliment Pharmacol Ther 2003;17:459-465.
28. Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009;124:292-300. This study supports the therapeutic benefit of oral peanut immunotherapy and also documents immunologic changes. This will encourage large trials to establish clinical efficacy for peanut desensitization.
29. Hoffmann AM, Scurlock AM, Jones SM, et al. Safety of oral immunotherapy peanut protocol in children with peanut allergy. J Allergy Clin Immunol 2009;124:284-291. Although the authors showed safety of the OIT protocol in well monitored selected study participants, this cannot be extrapolated to real-world patients until extensive clinical data are available.
30. Varshney P, Steele PH, Vickery BP, et al. Adverse reactions during peanut oral immunotherapy home dosing. J Allergy Clin Immunol 2009;124:1351-1352. In a letter to the editor, the researchers identify risk factors for reactions during oral peanut dosing.
31. Srivastava KD, Kattan JD, Zou ZM, et al. The Chinese herbal medicine formula FAHF2 completely blocks anaphylactic reactions in murine model of peanut allergy. J Allergy Clin Immunol 2005;115:171-178.
32. Qu C, Srivastava KD, Ko J, et al. Induction of tolerance after establishment of peanut allergy by food allergy herbal formula-2 is associated with up-regulation of interferon gamma. Clin Exp Allergy 2007;37:846-855.
33. Li XM, Brown L Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy. J Allergy Clin Immunol 2009;123:297-306. This article highlights the study data and mechanism/limitations of Chinese herbal medicine to treat asthma and peanut allergy.