Anti-inflammatory and analgesic effects displayed by peptides derived from PKI55 protein, an endogenous protein kinase C inhibitor

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 382, Issue 3, 2010, Pages 193-199

  Selvatici, Rita ^a   Congestrì, Francesco ^a   Marzola, Giuliano ^a   Guerrini, Remo ^a   Siniscalchi, Anna ^a   Spisani, Susanna ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

Analgesic effect; Corticosterone; Inflammation; PKC inhibitor; PKI55; Synthetic peptides

Indexed keywords

ACETIC ACID; ARGINYLCYSTEINYLTRYPTOPHYLLEUCYLGLUTAMINE; CORTICOSTERONE; CYSTEINYLARGINYLGLUTAMINYLLEUCYLTRYPTOPHAN; CYSTEINYLARGINYLGLUTAMINYLLEUCYLTRYPTOPHYLPHENYLALANYLSERYLCYSTEINE; DEXAMETHASONE; INDOMETACIN; METHIONYLLEUCYLTYROSYLLYSYLLEUCYLHISTIDYLASPARTYLVALYLCYSTEINYLARGINYLGLUTAMINYLLEUCYLTRYPTOPHYLPHENYLALANYLSERYLCYSTEINE; PEPTIDE DERIVATIVE; PROTEIN KINASE C INHIBITOR; PROTEIN PKI55; UNCLASSIFIED DRUG; XYLENE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; EXPERIMENTAL MODEL; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONEAL CAVITY;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INDOMETHACIN; INFLAMMATION; MALE; MICE; PAIN; PEPTIDES; PITUITARY-ADRENAL SYSTEM; PROTEIN KINASE C; PROTEINS;

EID: 77957600518     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-010-0536-3     Document Type: Article

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