Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5807-5810

  Watanabe, Takumi ^a   Umezawa, Yoji ^a   Takahashi, Yoshikazu ^a   Akamatsu, Yuzuru ^a  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

2,3 Oxidosqualene cyclase inhibitor; Hypercholesterolemia; Structure activity relationship; Virtual screening

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; ISOMERASE INHIBITOR; LANOSTEROL SYNTHASE; PYRROLE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; COMPUTER SIMULATION; ENZYME INHIBITORS; HUMANS; INTRAMOLECULAR TRANSFERASES; PROTEIN STRUCTURE, TERTIARY; PYRROLES; SQUALENE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 77957594054     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.131     Document Type: Article

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