메뉴 건너뛰기




Volumn 20, Issue 10, 2010, Pages 1138-1147

Proteasomal degradation unleashes the pro-death activity of androgen receptor

Author keywords

Androgen receptor; apoptosis; pro death domain; proteasomal degradation

Indexed keywords

ANDROGEN RECEPTOR; CASPASE; ENZYME INHIBITOR; PROTEASOME; PROTEIN BCL 2; SMALL INTERFERING RNA; STAUROSPORINE;

EID: 77957590904     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.65     Document Type: Article
Times cited : (10)

References (34)
  • 1
    • 28744456066 scopus 로고    scopus 로고
    • Role of androgen receptor in the progression of human prostate tumor cells to andro-gen independence and insensitivity
    • Kokontis JM, Hsu S, Chuu CP, et al. Role of androgen receptor in the progression of human prostate tumor cells to andro-gen independence and insensitivity. Prostate 2005; 65:287-298.
    • (2005) Prostate , vol.65 , pp. 287-298
    • Kokontis, J.M.1    Hsu, S.2    Chuu, C.P.3
  • 2
    • 0025106697 scopus 로고
    • Molecular cloning and structural analysis of complementary DNA of human and rat androgen receptors
    • Chang C, Kokontis J, Swift S, et al. Molecular cloning and structural analysis of complementary DNA of human and rat androgen receptors. Prog Clin Biol Res 1990; 322:53-63.
    • (1990) Prog Clin Biol Res , vol.322 , pp. 53-63
    • Chang, C.1    Kokontis, J.2    Swift, S.3
  • 3
    • 0042770258 scopus 로고
    • Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors
    • Chang CS, Kokontis J, Liao ST. Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors. Proc Natl Acad Sci USA 1988; 85:7211-7215.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 7211-7215
    • Chang, C.S.1    Kokontis, J.2    Liao, S.T.3
  • 4
    • 0041691050 scopus 로고    scopus 로고
    • Androgen receptors in prostate cancer
    • Culig Z, Klocker H, Bartsch G, et al. Androgen receptors in prostate cancer. J Urol 2003; 170:1363-1369.
    • (2003) J Urol , vol.170 , pp. 1363-1369
    • Culig, Z.1    Klocker, H.2    Bartsch, G.3
  • 5
    • 0142212410 scopus 로고    scopus 로고
    • The role of the androgen receptor in the development of prostatic hyperplasia and prostate cancer
    • Chatterjee B. The role of the androgen receptor in the development of prostatic hyperplasia and prostate cancer. Mol Cell Biochem 2003; 253:89-101.
    • (2003) Mol Cell Biochem , vol.253 , pp. 89-101
    • Chatterjee, B.1
  • 6
    • 0030948745 scopus 로고    scopus 로고
    • Traffcking of the androgen receptor in living cells with fused green fuores-cent protein-androgen receptor
    • Georget V, Lobaccaro JM, Terouanne B, et al. Traffcking of the androgen receptor in living cells with fused green fuores-cent protein-androgen receptor. Mol Cell Endocrinol 1997; 129:17-26.
    • (1997) Mol Cell Endocrinol , vol.129 , pp. 17-26
    • Georget, V.1    Lobaccaro, J.M.2    Terouanne, B.3
  • 7
    • 0035958949 scopus 로고    scopus 로고
    • The subnuclear three-dimensional image analysis of androgen receptor fused to green fluorescence protein
    • Tomura A, Goto K, Morinaga H, et al. The subnuclear three-dimensional image analysis of androgen receptor fused to green fluorescence protein. J Biol Chem 2001; 276:28395-28401.
    • (2001) J Biol Chem , vol.276 , pp. 28395-28401
    • Tomura, A.1    Goto, K.2    Morinaga, H.3
  • 8
    • 0024842043 scopus 로고
    • Androgen receptors: Structures, mutations, antibodies and cellular dynamics
    • Liao SS, Kokontis J, Sai T, et al. Androgen receptors: structures, mutations, antibodies and cellular dynamics. J Steroid Biochem 1989; 34:41-51.
    • (1989) J Steroid Biochem , vol.34 , pp. 41-51
    • Liao, S.S.1    Kokontis, J.2    Sai, T.3
  • 9
    • 0029914188 scopus 로고    scopus 로고
    • Delineation of two distinct type 1 activation functions in the androgen receptor amino-terminal domain
    • Chamberlain NL, Whitacre DC, Miesfeld RL. Delineation of two distinct type 1 activation functions in the androgen receptor amino-terminal domain. J Biol Chem 1996; 271:26772-26778.
    • (1996) J Biol Chem , vol.271 , pp. 26772-26778
    • Chamberlain, N.L.1    Whitacre, D.C.2    Miesfeld, R.L.3
  • 10
    • 27744511919 scopus 로고    scopus 로고
    • Structure and function of steroid receptor AF1 transactivation domains: Induction of active conformations
    • Lavery DN, McEwan IJ. Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations. Biochem J 2005; 391:449-464.
    • (2005) Biochem J , vol.391 , pp. 449-464
    • Lavery, D.N.1    McEwan, I.J.2
  • 11
    • 0029041681 scopus 로고
    • Identifcation of three proline-directed phosphorylation sites in the human androgen receptor
    • Zhou ZX, Kemppainen JA, Wilson EM. Identifcation of three proline-directed phosphorylation sites in the human androgen receptor. Mol Endocrinol 1995; 9:605-615.
    • (1995) Mol Endocrinol , vol.9 , pp. 605-615
    • Zhou, Z.X.1    Kemppainen, J.A.2    Wilson, E.M.3
  • 12
    • 0029814415 scopus 로고    scopus 로고
    • Activation of the human androgen receptor through a protein kinase A signaling pathway
    • Nazareth LV, Weigel NL. Activation of the human androgen receptor through a protein kinase A signaling pathway. J Biol Chem 1996; 271:19900-19907.
    • (1996) J Biol Chem , vol.271 , pp. 19900-19907
    • Nazareth, L.V.1    Weigel, N.L.2
  • 13
    • 19044380048 scopus 로고    scopus 로고
    • Androgen receptor phosphorylation. Regulation and identification of the phos-phorylation sites
    • Gioeli D, Ficarro SB, Kwiek JJ, et al. Androgen receptor phosphorylation. Regulation and identification of the phos-phorylation sites. J Biol Chem 2002; 277:29304-29314.
    • (2002) J Biol Chem , vol.277 , pp. 29304-29314
    • Gioeli, D.1    Ficarro, S.B.2    Kwiek, J.J.3
  • 14
    • 0036668568 scopus 로고    scopus 로고
    • Cloning and characterization of an androgen receptor N-terminal- interacting protein with ubiquitin-protein ligase activity
    • Beitel LK, Elhaji YA, Lumbroso R, et al. Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity. J Mol Endocrinol 2002; 29:41-60.
    • (2002) J Mol Endocrinol , vol.29 , pp. 41-60
    • Beitel, L.K.1    Elhaji, Y.A.2    Lumbroso, R.3
  • 15
    • 0034687807 scopus 로고    scopus 로고
    • Covalent modifca-tion of the androgen receptor by small ubiquitin-like modifer 1 (SUMO-1)
    • Poukka H, Karvonen U, Janne OA, et al. Covalent modifca-tion of the androgen receptor by small ubiquitin-like modifer 1 (SUMO-1). Proc Natl Acad Sci USA 2000; 97:14145-14150.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 14145-14150
    • Poukka, H.1    Karvonen, U.2    Janne, O.A.3
  • 16
    • 51549094259 scopus 로고    scopus 로고
    • Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
    • Claessens F, Denayer S, Van Tilborgh N, et al. Diverse roles of androgen receptor (AR) domains in AR-mediated signaling. Nucl Recept Signal 2008; 6:e008.
    • (2008) Nucl Recept Signal , vol.6
    • Claessens, F.1    Denayer, S.2    Van Tilborgh, N.3
  • 17
    • 50649119649 scopus 로고    scopus 로고
    • Androgen receptor-mediated apoptosis is regulated by photoactivatable androgen receptor ligands
    • Risek B, Bilski P, Rice AB, et al. Androgen receptor-mediated apoptosis is regulated by photoactivatable androgen receptor ligands. Mol Endocrinol 2008; 22:2099-2115.
    • (2008) Mol Endocrinol , vol.22 , pp. 2099-2115
    • Risek, B.1    Bilski, P.2    Rice, A.B.3
  • 18
    • 0034612780 scopus 로고    scopus 로고
    • Apoptosis: Translating theory to therapy for prostate cancer
    • Isaacs JT. Apoptosis: translating theory to therapy for prostate cancer. J Natl Cancer Inst 2000; 92:1367-1369.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1367-1369
    • Isaacs, J.T.1
  • 19
    • 0031024251 scopus 로고    scopus 로고
    • Androgen-depen-dent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor
    • Heisler LE, Evangelou A, Lew AM, et al. Androgen-depen-dent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor. Mol Cell Endocrinol 1997; 126:59-73.
    • (1997) Mol Cell Endocrinol , vol.126 , pp. 59-73
    • Heisler, L.E.1    Evangelou, A.2    Lew, A.M.3
  • 20
    • 60849095522 scopus 로고    scopus 로고
    • Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk
    • Young JE, Garden GA, Martinez RA, et al. Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. J Neurosci 2009; 29:1987-1997.
    • (2009) J Neurosci , vol.29 , pp. 1987-1997
    • Young, J.E.1    Garden, G.A.2    Martinez, R.A.3
  • 21
    • 0034633661 scopus 로고    scopus 로고
    • Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells
    • Yeh S, Hu YC, Rahman M, et al. Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. Proc Natl Acad Sci USA 2000; 97:11256-11261.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11256-11261
    • Yeh, S.1    Hu, Y.C.2    Rahman, M.3
  • 22
    • 33644525895 scopus 로고    scopus 로고
    • Androgen and its receptor promote bax-mediated apoptosis
    • Lin Y, Kokontis J, Tang F, et al. Androgen and its receptor promote bax-mediated apoptosis. Mol Cell Biol 2006; 26:1908-1916.
    • (2006) Mol Cell Biol , vol.26 , pp. 1908-1916
    • Lin, Y.1    Kokontis, J.2    Tang, F.3
  • 23
    • 38849159211 scopus 로고    scopus 로고
    • The role of the poly-glutamine tract in androgen receptor
    • Palazzolo I, Gliozzi A, Rusmini P, et al. The role of the poly-glutamine tract in androgen receptor. J Steroid Biochem Mol Biol 2008; 108:245-253.
    • (2008) J Steroid Biochem Mol Biol , vol.108 , pp. 245-253
    • Palazzolo, I.1    Gliozzi, A.2    Rusmini, P.3
  • 24
    • 0032898311 scopus 로고    scopus 로고
    • Kennedy's disease: Caspase cleavage of the androgen receptor is a crucial event in cytotoxicity
    • Ellerby LM, Hackam AS, Propp SS, et al. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem 1999; 72:185-195.
    • (1999) J Neurochem , vol.72 , pp. 185-195
    • Ellerby, L.M.1    Hackam, A.S.2    Propp, S.S.3
  • 25
    • 54049150008 scopus 로고    scopus 로고
    • Calpain-mediated andro-gen receptor breakdown in apoptotic prostate cancer cells
    • Yang H, Murthy S, Sarkar FH, et al. Calpain-mediated andro-gen receptor breakdown in apoptotic prostate cancer cells. J Cell Physiol 2008; 217:569-576.
    • (2008) J Cell Physiol , vol.217 , pp. 569-576
    • Yang, H.1    Murthy, S.2    Sarkar, F.H.3
  • 26
    • 35148833549 scopus 로고    scopus 로고
    • Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence
    • Libertini SJ, Tepper CG, Rodriguez V, et al. Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence. Cancer Res 2007; 67:9001-9005.
    • (2007) Cancer Res , vol.67 , pp. 9001-9005
    • Libertini, S.J.1    Tepper, C.G.2    Rodriguez, V.3
  • 27
    • 0034675275 scopus 로고    scopus 로고
    • Inhibiting proteasomes in human HepG2 and LNCaP cells increases endogenous an-drogen receptor levels
    • Shefin L, Keegan B, Zhang W, et al. Inhibiting proteasomes in human HepG2 and LNCaP cells increases endogenous an-drogen receptor levels. Biochem Biophys Res Commun 2000; 276:144-150.
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 144-150
    • Shefin, L.1    Keegan, B.2    Zhang, W.3
  • 28
    • 0034708793 scopus 로고    scopus 로고
    • Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract
    • Kobayashi Y, Kume A, Li M, et al. Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem 2000; 275:8772-8778.
    • (2000) J Biol Chem , vol.275 , pp. 8772-8778
    • Kobayashi, Y.1    Kume, A.2    Li, M.3
  • 29
    • 50449088732 scopus 로고    scopus 로고
    • Androgen receptor is a tumor suppressor and proliferator in prostate cancer
    • Niu Y, Altuwaijri S, Lai KP, et al. Androgen receptor is a tumor suppressor and proliferator in prostate cancer. Proc Natl Acad Sci USA 2008; 105:12182-12187.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 12182-12187
    • Niu, Y.1    Altuwaijri, S.2    Lai, K.P.3
  • 30
    • 33750541268 scopus 로고    scopus 로고
    • Down-regulation of an-drogen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells
    • Bhuiyan MM, Li Y, Banerjee S, et al. Down-regulation of an-drogen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer Res 2006; 66:10064-10072.
    • (2006) Cancer Res , vol.66 , pp. 10064-10072
    • Bhuiyan, M.M.1    Li, Y.2    Banerjee, S.3
  • 31
    • 34047227818 scopus 로고    scopus 로고
    • GCP-mediated growth inhibition and apoptosis of prostate cancer cells via androgen receptor-dependent and-independent mechanisms
    • Tepper CG, Vinall RL, Wee CB, et al. GCP-mediated growth inhibition and apoptosis of prostate cancer cells via androgen receptor-dependent and-independent mechanisms. Prostate 2007; 67:521-535.
    • (2007) Prostate , vol.67 , pp. 521-535
    • Tepper, C.G.1    Vinall, R.L.2    Wee, C.B.3
  • 32
    • 0035038460 scopus 로고    scopus 로고
    • Extended polyglutamine selectively interacts with caspase-8 and-10 in nuclear aggregates
    • U M, Miyashita T, Ohtsuka Y, et al. Extended polyglutamine selectively interacts with caspase-8 and-10 in nuclear aggregates. Cell Death Differ 2001; 8:377-386.
    • (2001) Cell Death Differ , vol.8 , pp. 377-386
    • Miyashita, T.1    Ohtsuka, Y.2
  • 33
    • 0033591047 scopus 로고    scopus 로고
    • Expression of extended polyglutamine sequentially activates initiator and effector caspases
    • Miyashita T, Matsui J, Ohtsuka Y, et al. Expression of extended polyglutamine sequentially activates initiator and effector caspases. Biochem Biophys Res Commun 1999; 257:724-730.
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 724-730
    • Miyashita, T.1    Matsui, J.2    Ohtsuka, Y.3
  • 34
    • 0034153542 scopus 로고    scopus 로고
    • Pro-apoptotic treatment with an adenovirus encoding Bax enhances the effect of chemotherapy in ovarian cancer
    • Xiang J, Gomez-Navarro J, Arafat W, et al. Pro-apoptotic treatment with an adenovirus encoding Bax enhances the effect of chemotherapy in ovarian cancer. J Gene Med 2000; 2:97-106.
    • (2000) J Gene Med , vol.2 , pp. 97-106
    • Xiang, J.1    Gomez-Navarro, J.2    Arafat, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.